scholarly journals A Randomized Double-Blind Sham-Controlled Study of Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression

2012 ◽  
Vol 3 ◽  
Author(s):  
Daniel M. Blumberger ◽  
Lisa C. Tran ◽  
Paul B. Fitzgerald ◽  
Kate E. Hoy ◽  
Zafiris J. Daskalakis
Keyword(s):  
Major Depression ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Study ◽  
Treatment Resistant ◽  
Double Blind ◽  
Direct Current Stimulation

Transcranial Direct Current Stimulation for Treatment-Resistant Major Depression: A Double-Blind Randomized Sham-Controlled Trial

2019 ◽  
Vol 50 (6) ◽  
pp. 375-382 ◽  
Author(s):  
Elham Sharafi ◽  
Arsia Taghva ◽  
Mohammad Arbabi ◽  
Afsaneh Dadarkhah ◽  
Jamshid Ghaderi
Keyword(s):  
Major Depression ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Trial ◽  
Active Group ◽  
Treatment Resistant ◽  
Double Blind ◽  
Direct Current Stimulation ◽  
Significant Difference ◽  
The Mean

In the current study, we tried to evaluate the effect of transcranial direct current stimulation (tDCS) on treatment-resistant major depression. We carried out a double-blind randomized sham-controlled trial was conducted in University Hospitals. Individuals with less than 50% decrease in the intensity of depression after 8 weeks of treatment with selective serotonin reuptake inhibitors were recruited. Thirty patients (16 women) with a mean (SD) age of 47.2 (12.0) years were randomly allocated to 2 groups. For the active group we administered 2-mA stimulation 20 minutes for each session, with 30 seconds ramp-up from 0 and 30 seconds ramp-down. For the sham group we administered 30 seconds ramp-up to 2 mA, 10 seconds stimulation, 30 seconds ramp-down, and 20 minutes no current. The anode was fixed on the center of F3, and the cathode on F4, over the dorsolateral prefrontal cortex. We assessed the Hamilton Depression Rating Scale at the baseline (mean difference = 1.0, P = .630), at the last session of tDCS, and at 1-month postintervention. There were statistically significant differences in the mean Hamilton scores after the intervention, and 1 month later in favor of active group; P < .001, and P = .003, respectively. Mixed analysis of variance showed a significant difference in the mean scores for active group P = .010 and pattern of change during the study P < .001 in favor of active intervention. We concluded that tDCS is an efficient therapy for patients with resistant major depression, and the benefits would remain at least for 1 month.

scholarly journals Aging, sex and cognitive Theory of Mind: a transcranial direct current stimulation study

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Mauro Adenzato ◽  
Rosa Manenti ◽  
Elena Gobbi ◽  
Ivan Enrici ◽  
Danila Rusich ◽  
...  
Keyword(s):  
Social Cognition ◽  
Theory Of Mind ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Cognitive Abilities ◽  
Healthy Aging ◽  
Cognitive Theory ◽  
Controlled Study ◽  
Double Blind ◽  
Direct Current Stimulation

AbstractAging is accompanied by changes in cognitive abilities and a great interest is spreading among researchers about aging impact on social cognition skills, such as the Theory of Mind (ToM). Transcranial direct current stimulation (tDCS) has been used in social cognition studies founding evidence of sex-related different effects on cognitive ToM task in a young people sample. In this randomized, double-blind, sham-controlled study, we applied one active and one sham tDCS session on the medial prefrontal cortex (mPFC) during a cognitive ToM task, including both social (i.e., communicative) and nonsocial (i.e., private) intention attribution conditions, in sixty healthy aging individuals (30 males and 30 females). In half of the participants the anode was positioned over the mPFC, whereas in the other half the cathode was positioned over the mPFC. The results showed that: (i) anodal tDCS over the mPFC led to significant slower reaction times (vs. sham) for social intention attribution task only in female participants; (ii) No effects were found in both females and males during cathodal stimulation. We show for the first time sex-related differences in cognitive ToM abilities in healthy aging, extending previous findings concerning young participants.

scholarly journals Transcranial Direct Current Stimulation for Obsessive-Compulsive Disorder: A Systematic Review

2018 ◽  
Vol 8 (2) ◽  
pp. 37 ◽  
Author(s):  
Jérôme Brunelin ◽  
Marine Mondino ◽  
Rémy Bation ◽  
Ulrich Palm ◽  
Mohamed Saoud ◽  
...  
Keyword(s):  
Obsessive Compulsive Disorder ◽  
Direct Current ◽  
Transcranial Direct Current Stimulation ◽  
Controlled Study ◽  
Treatment Resistant ◽  
Obsessive Compulsive ◽  
Compulsive Disorder ◽  
Direct Current Stimulation ◽  
Manual Search ◽  
Pubmed Database

Despite the advances in psychopharmacology and established psychotherapeutic interventions, more than 40% of patients with obsessive-compulsive disorder (OCD) do not respond to conventional treatment approaches. Transcranial direct current stimulation (tDCS) has been recently proposed as a therapeutic tool to alleviate treatment-resistant symptoms in patients with OCD. The aim of this review was to provide a comprehensive overview of the current state of the art and future clinical applications of tDCS in patients with OCD. A literature search conducted on the PubMed database following PRISMA guidelines and completed by a manual search yielded 12 results: eight case reports, three open-label studies (with 5, 8, and 42 participants), and one randomized trial with two active conditions (12 patients). There was no sham-controlled study. A total of 77 patients received active tDCS with a large diversity of electrode montages mainly targeting the dorsolateral prefrontal cortex, the orbitofrontal cortex or the (pre-) supplementary motor area. Despite methodological limitations and the heterogeneity of stimulation parameters, tDCS appears to be a promising tool to decrease obsessive-compulsive symptoms as well as comorbid depression and anxiety in patients with treatment-resistant OCD. Further sham-controlled studies are needed to confirm these preliminary results.

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