scholarly journals Use of High Resolution 3D Diffusion Tensor Imaging to Study Brain White Matter Development in Live Neonatal Rats

2011 ◽  
Vol 2 ◽  
Author(s):  
Yu Cai ◽  
Matthew S. McMurray ◽  
Ipek Oguz ◽  
Hong Yuan ◽  
Martin A. Styner ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
High Resolution ◽  
Diffusion Tensor ◽  
Neonatal Rats ◽  
Brain White Matter ◽  
White Matter Development

scholarly journals White Matter Integrity Predicts Delay Discounting Behavior in 9- to 23-Year-Olds: A Diffusion Tensor Imaging Study

2009 ◽  
Vol 21 (7) ◽  
pp. 1406-1421 ◽  
Author(s):  
Elizabeth A. Olson ◽  
Paul F. Collins ◽  
Catalina J. Hooper ◽  
Ryan Muetzel ◽  
Kelvin O. Lim ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Delay Discounting ◽  
Diffusion Tensor ◽  
Mean Diffusivity ◽  
Imaging Study ◽  
Temporal Lobes ◽  
Brain White Matter ◽  
Independent Effects ◽  
Age Range

Healthy participants (n = 79), ages 9–23, completed a delay discounting task assessing the extent to which the value of a monetary reward declines as the delay to its receipt increases. Diffusion tensor imaging (DTI) was used to evaluate how individual differences in delay discounting relate to variation in fractional anisotropy (FA) and mean diffusivity (MD) within whole-brain white matter using voxel-based regressions. Given that rapid prefrontal lobe development is occurring during this age range and that functional imaging studies have implicated the prefrontal cortex in discounting behavior, we hypothesized that differences in FA and MD would be associated with alterations in the discounting rate. The analyses revealed a number of clusters where less impulsive performance on the delay discounting task was associated with higher FA and lower MD. The clusters were located primarily in bilateral frontal and temporal lobes and were localized within white matter tracts, including portions of the inferior and superior longitudinal fasciculi, anterior thalamic radiation, uncinate fasciculus, inferior fronto-occipital fasciculus, corticospinal tract, and splenium of the corpus callosum. FA increased and MD decreased with age in the majority of these regions. Some, but not all, of the discounting/DTI associations remained significant after controlling for age. Findings are discussed in terms of both developmental and age-independent effects of white matter organization on discounting behavior.

Human Brain Diffusion Tensor Imaging Visualization With Virtual Reality

2010 ◽  
Author(s):  
Bin Chen ◽  
John Moreland
Keyword(s):  
Virtual Reality ◽  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Biological Tissues ◽  
Head Tracking ◽  
Fiber Tractography ◽  
Brain White Matter ◽  
Diffusion Tensors ◽  
Visualization Techniques

Magnetic resonance diffusion tensor imaging (DTI) is sensitive to the anisotropic diffusion of water exerted by its macromolecular environment and has been shown useful in characterizing structures of ordered tissues such as the brain white matter, myocardium, and cartilage. The water diffusivity inside of biological tissues is characterized by the diffusion tensor, a rank-2 symmetrical 3×3 matrix, which consists of six independent variables. The diffusion tensor contains much information of diffusion anisotropy. However, it is difficult to perceive the characteristics of diffusion tensors by looking at the tensor elements even with the aid of traditional three dimensional visualization techniques. There is a need to fully explore the important characteristics of diffusion tensors in a straightforward and quantitative way. In this study, a virtual reality (VR) based MR DTI visualization with high resolution anatomical image segmentation and registration, ROI definition and neuronal white matter fiber tractography visualization and fMRI activation map integration is proposed. The VR application will utilize brain image visualization techniques including surface, volume, streamline and streamtube rendering, and use head tracking and wand for navigation and interaction, the application will allow the user to switch between different modalities and visualization techniques, as well making point and choose queries. The main purpose of the application is for basic research and clinical applications with quantitative and accurate measurements to depict the diffusivity or the degree of anisotropy derived from the diffusion tensor.

scholarly journals A novel maturation index based on neonatal diffusion tensor imaging reflects typical perinatal white matter development in humans

2016 ◽  
Vol 56 (1) ◽  
pp. 42-51 ◽  
Author(s):  
Jerod M. Rasmussen ◽  
Frithjof Kruggel ◽  
John H. Gilmore ◽  
Martin Styner ◽  
Sonja Entringer ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
White Matter Development ◽  
Maturation Index

scholarly journals Diffusion Tensor Imaging Mapping of Brain White Matter Pathology in Mitochondrial Optic Neuropathies

2015 ◽  
Vol 36 (7) ◽  
pp. 1259-1265 ◽  
Author(s):  
D. N. Manners ◽  
G. Rizzo ◽  
C. La Morgia ◽  
C. Tonon ◽  
C. Testa ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Brain White Matter ◽  
White Matter Pathology

White matter development during late adolescence in healthy males: A cross-sectional diffusion tensor imaging study

NeuroImage ◽  
2007 ◽  
Vol 35 (2) ◽  
pp. 501-510 ◽  
Author(s):  
Manzar Ashtari ◽  
Kelly L. Cervellione ◽  
Khader M. Hasan ◽  
Jinghui Wu ◽  
Carolyn McIlree ◽  
...  
Keyword(s):  
Diffusion Tensor Imaging ◽  
White Matter ◽  
Diffusion Tensor ◽  
Imaging Study ◽  
Late Adolescence ◽  
Cross Sectional ◽  
White Matter Development ◽  
Diffusion Tensor Imaging Study ◽  
Healthy Males
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