scholarly journals Adolescent Opiate Exposure in the Female Rat Induces Subtle Alterations in Maternal Care and Transgenerational Effects on Play Behavior

2011 ◽  
Vol 2 ◽  
Author(s):  
Nicole L. Johnson ◽  
Lindsay Carini ◽  
Marian E. Schenk ◽  
Michelle Stewart ◽  
Elizabeth M. Byrnes
Keyword(s):  
Maternal Care ◽  
Play Behavior ◽  
Female Rat ◽  
Transgenerational Effects

scholarly journals Early life variations in temperature exposure affect the epigenetic regulation of the paraventricular nucleus in female rat pups

2020 ◽  
Vol 287 (1937) ◽  
pp. 20201991
Author(s):  
Samantha C. Lauby ◽  
Patrick O. McGowan
Keyword(s):  
Dna Methylation ◽  
Thyroid Hormone ◽  
Maternal Care ◽  
Hormone Receptor ◽  
Room Temperature ◽  
Thyroid Hormone Receptor ◽  
Female Rat ◽  
Receptor Signalling ◽  
Rat Pups ◽  
Temperature Exposure

Early life maternal care received has a profound effect on later-life behaviour in adult offspring, and previous studies have suggested epigenetic mechanisms are involved. Changes in thyroid hormone receptor signalling may be related to differences in maternal care received and DNA methylation modifications. We investigated the effects of variations in temperature exposure (a proxy of maternal contact) and licking-like tactile stimulation on these processes in week-old female rat pups. We assessed thyroid hormone receptor signalling by measuring circulating triiodothyronine and transcript abundance of thyroid hormone receptors and the thyroid hormone-responsive genes DNA methyltransferase 3a and oxytocin in the paraventricular nucleus of the hypothalamus. DNA methylation of the oxytocin promoter was assessed in relation to changes in thyroid hormone receptor binding. Repeated room temperature exposure was associated with a decrease in thyroid hormone receptor signalling measures relative to nest temperature exposure, while acute room temperature exposure was associated with an increase. Repeated room temperature exposure also increased thyroid hormone receptor binding and DNA methylation at the oxytocin promoter. These findings suggest that repeated room temperature exposure may affect DNA methylation levels as a consequence of alterations in thyroid hormone receptor signalling.

scholarly journals Short-term benefits, but transgenerational costs of maternal loss in an insect with facultative maternal care

2015 ◽  
Vol 282 (1817) ◽  
pp. 20151617 ◽  
Author(s):  
Julia Thesing ◽  
Jos Kramer ◽  
Lisa K. Koch ◽  
Joël Meunier
Keyword(s):  
Parental Care ◽  
Family Life ◽  
Maternal Care ◽  
Life Experience ◽  
Developmental Time ◽  
Early Evolution ◽  
Transgenerational Effects ◽  
Short Term ◽  
Maternal Loss ◽  
Forficula Auricularia

A lack of parental care is generally assumed to entail substantial fitness costs for offspring that ultimately select for the maintenance of family life across generations. However, it is unknown whether these costs arise when parental care is facultative, thus questioning their fundamental importance in the early evolution of family life. Here, we investigated the short-term, long-term and transgenerational effects of maternal loss in the European earwig Forficula auricularia , an insect with facultative post-hatching maternal care. We showed that maternal loss did not influence the developmental time and survival rate of juveniles, but surprisingly yielded adults of larger body and forceps size, two traits associated with fitness benefits. In a cross-breeding/cross-fostering experiment, we then demonstrated that maternal loss impaired the expression of maternal care in adult offspring. Interestingly, the resulting transgenerational costs were not only mediated by the early-life experience of tending mothers, but also by inherited, parent-of-origin-specific effects expressed in juveniles. Orphaned females abandoned their juveniles for longer and fed them less than maternally-tended females, while foster mothers defended juveniles of orphaned females less well than juveniles of maternally-tended females. Overall, these findings reveal the key importance of transgenerational effects in the early evolution of family life.

Effect of paracetamol treatment on maternal care and reproductive outcomes in female rat offspring

2020 ◽  
Vol 32 (18) ◽  
pp. 1311
Author(s):  
Jeberson F. Aleixo ◽  
Marina R. F. Pereira ◽  
Bruno G. Montagnini ◽  
Matheus Junior D. Pereira ◽  
Simone Forcato ◽  
...  
Keyword(s):  
Sexual Development ◽  
Maternal Care ◽  
Wistar Rats ◽  
Reproductive Behaviour ◽  
Female Offspring ◽  
Female Rat ◽  
Anogenital Distance ◽  
Rat Offspring ◽  
Grooming Behaviour ◽  
Plasma Oestradiol

Paracetamol (PAR) is one of the most commonly used drugs by pregnant women because it is considered safe for the mother and fetus. However, PAR is transferred into breast milk and crosses the blood–placental barrier, being present in the progeny during important stages of development. Intrauterine exposure to PAR may decrease the anogenital distance and follicle reserve in female rodent offspring. Therefore, the aim of the present study was to evaluate whether maternal PAR treatment altered the reproductive behaviour of dams and the sexual development of female rat offspring. Pregnant Wistar rats were gavaged daily with 350mg kg−1 day−1 PAR or water during gestation (from Gestation Day (GD) 6 until delivery) or during gestation and lactation (from GD6 until weaning). Maternal PAR treatment had maternal effects (increased grooming behaviour), and resulted in impaired sexual behaviour, decreased follicle reserve and increased plasma oestradiol concentrations in female offspring.

Effects of pre-reproductive maternal enrichment on maternal care, offspring's play behavior and oxytocinergic neurons

2019 ◽  
Vol 145 ◽  
pp. 99-113 ◽  
Author(s):  
Debora Cutuli ◽  
Erica Berretta ◽  
Paola Caporali ◽  
Patricia Sampedro-Piquero ◽  
Paola De Bartolo ◽  
...  
Keyword(s):  
Maternal Care ◽  
Play Behavior ◽  
Oxytocinergic Neurons

Transgenerational effects of maternal care interact with fetal growth and influence attention skills at 18months of age

2014 ◽  
Vol 90 (5) ◽  
pp. 241-246 ◽  
Author(s):  
Marla F. Neuwald ◽  
Marilyn Agranonik ◽  
André K. Portella ◽  
Alison Fleming ◽  
Ashley Wazana ◽  
...  
Keyword(s):  
Fetal Growth ◽  
Maternal Care ◽  
Transgenerational Effects ◽  
Attention Skills

scholarly journals Maternal care modulates transgenerational effects of endocrine-disrupting chemicals on offspring pup vocalizations and adult behaviors

2019 ◽  
Vol 107 ◽  
pp. 96-109 ◽  
Author(s):  
Krittika Krishnan ◽  
Shafaqat Rahman ◽  
Asbiel Hasbum ◽  
Daniel Morales ◽  
Lindsay M. Thompson ◽  
...  
Keyword(s):  
Maternal Care ◽  
Endocrine Disrupting Chemicals ◽  
Transgenerational Effects ◽  
Endocrine Disrupting

Transgenerational effects of impaired maternal care on behaviour of offspring and grandoffspring

2008 ◽  
Vol 75 (4) ◽  
pp. 1551-1561 ◽  
Author(s):  
J.P. Curley ◽  
F.A. Champagne ◽  
P. Bateson ◽  
E.B. Keverne
Keyword(s):  
Maternal Care ◽  
Transgenerational Effects
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