scholarly journals Cognitive Performance and Psychological Distress in Breast Cancer Patients at Disease Onset

2019 ◽  
Vol 10 ◽  
Author(s):  
Jochen Kaiser ◽  
Jörg Dietrich ◽  
Miena Amiri ◽  
Isa Rüschel ◽  
Hazal Akbaba ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Cognitive Performance ◽  
Disease Onset ◽  
Breast Cancer Patients

scholarly journals Effective clinical psychological interventions for breast cancer patients with psychological distress

2013 ◽  
Vol 8 (1) ◽  
pp. 301-311
Author(s):  
Naoko Nagai ◽  
Takashi Morimoto ◽  
Takashi Nomura ◽  
Yo Sasaki ◽  
Osamu Honda
Keyword(s):  
Breast Cancer ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Psychological Interventions ◽  
Breast Cancer Patients

scholarly journals Managing Cancer and Living Meaningfully (CALM) Intervention on Chemotherapy-Related Cognitive Impairment in Breast Cancer Survivors

2020 ◽  
Vol 19 ◽  
pp. 153473542093845
Author(s):  
Ke Ding ◽  
Xiuqing Zhang ◽  
Jingjing Zhao ◽  
He Zuo ◽  
Ziran Bi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cognitive Impairment ◽  
Psychological Distress ◽  
Cognitive Function ◽  
Cancer Therapy ◽  
Cancer Patients ◽  
Functional Assessment ◽  
Breast Cancer Survivors ◽  
Breast Cancer Patients ◽  
Before And After

Objective: To evaluate the effectiveness and feasibility of Managing Cancer and Living Meaningfully (CALM), which is used to reduce chemotherapy-related cognitive impairment (CRCI), relieve psychological distress, and improve quality of life (QOL) in Chinese breast cancer survivors (BCs). Methods: Seventy-four BCs were enrolled in this study. All patients were randomly assigned to either the CALM group or the care as usual (CAU) group. All patients were evaluated by the Functional Assessment of Cancer Therapy–Cognitive Function (FACT-Cog), Distress Thermometer (DT), and the Functional Assessment of Cancer Therapy–Breast (FACT-B) before and after CALM or CAU application to BCs with CRCI. We compared the differences in all these scores between the CALM group and the control group and analyzed the correlation between cognitive function and QOL. Results: Compared with the CAU group, the performance of the CALM group on the FACT-Cog, DT, and FACT-B showed significant differences before and after CALM ( t = −18.909, −5.180, −32.421, P = .000, .000, .000, respectively). Finally, there was a positive correlation between cognitive function and QOL in breast cancer patients before ( r = 0.579, P = .000) and after ( r = 0.797, P = .000) treatment. Conclusions: The present results indicated that CALM has salutary effects on the improvement of cognitive impairment and QOL and relieves psychological distress in breast cancer patients, which may be due to a positive correlation between psychological distress and cognitive function or QOL.

Superior survival of breast cancer BRCA1 /2 mutation carriers harboringG/G at the -309 position at the MDM2 promoter compared to those harboring T/T or G/T at this SNP

2007 ◽  
Vol 25 (18_suppl) ◽  
pp. 10600-10600
Author(s):  
H. Nechushtan ◽  
T. Hamburger ◽  
S. Mendelson ◽  
L. Kadouri ◽  
N. Sharon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Germ Line ◽  
Age Of Onset ◽  
Disease Onset ◽  
Rank Test ◽  
Breast Cancer Patients ◽  
Mdm2 Snp309 ◽  
Li Fraumeni Syndrome ◽  
Mutation Carriers

10600 Background: A germ line single polymorphism in the promoter of the gene encoding the important modulator of P53, MDM2 has been described. The findings of G/G nucleotides at this position in contrast to G/Tor T/T were demonstrated to increase MDM2 transcriptional levels and were correlated with younger onset of cancers in patients with the Li-Fraumeni syndrome. Furhtermore gastric cancer patients harboring T/T at this position and treated with chemotherapy were found to have decresed survival compared to the other SNP carriers. P53 mutations appear in high frequency in tumors associated with BRCA1/2 mutations. Indeed it has been suggested that mutations in the p53 gene are a necessary step in tumorigenesis in BRCA tumors. Methods: Here we investigate the effect of the MDM2 SNP309 on overall survival and age of onset in breast cancer patients. MDM2 SNP309 was evaluated in Breast cancer Ashkenazy patients analyzed for the three common mutations in BRCA1/2- 180 patients who are positive for either of these mutation and 272 negative ones. 194 negative, Disease onset age and survival were analyzed for the different subgroups Results: Around a quarter of the whole population analyzed were identified as carriers of G/G at the -309 MDM2. There was no correlation between age of disease onset in either BRCA1/2mutation carriers and the specific genotype. In the BRCA1/2 mutation carriers we found a survival advantage in patients harboring the SNP309 G/G genotype(p-0.001 log rank test). Such an effect was not demonstrated in patients tested negative for the known Ashkenazy mutations Conclusions: In specific subgroups of breast cancer patients SNP309 G/G is associated with improved patient survival. A possible explanation for this finding could be the presence of a P53 which can be reactivated in the MDM2 SNP309 G/G carriers. No significant financial relationships to disclose.

Associated factors with psychological distress in Moroccan breast cancer patients: A cross-sectional study

The Breast ◽  
2017 ◽  
Vol 31 ◽  
pp. 26-33 ◽  
Author(s):  
Soufiane Berhili ◽  
Selma Kadiri ◽  
Amal Bouziane ◽  
Abdallah Aissa ◽  
Elamin Marnouche ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Associated Factors ◽  
Cross Sectional Study ◽  
Breast Cancer Patients ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals The effects of the COVID-19 pandemic on psychological stress in breast cancer patients

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Catharina Bartmann ◽  
Leah-Maria Fischer ◽  
Theresa Hübner ◽  
Max Müller-Reiter ◽  
Achim Wöckel ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Psychological Distress ◽  
Cancer Patients ◽  
Psychological Stress ◽  
Psychological Health ◽  
Life Quality ◽  
Breast Cancer Diagnosis ◽  
Female Breast Cancer ◽  
Breast Cancer Patients ◽  
European Organization

Abstract Background The majority of breast cancer patients are severely psychologically affected by breast cancer diagnosis and subsequent therapeutic procedures. The COVID-19 pandemic and associated restrictions on public life have additionally caused significant psychological distress for much of the population. It is therefore plausible that breast cancer patients might be particularly susceptible to the additional psychological stress caused by the pandemic, increasing suffering. In this study we therefore aimed to assess the level of psychological distress currently experienced by a defined group of breast cancer patients in our breast cancer centre, compared to distress levels pre-COVID-19 pandemic. Methods Female breast cancer patients of all ages receiving either adjuvant, neoadjuvant, or palliative therapies were recruited for the study. All patients were screened for current or previous COVID-19 infection. The participants completed a self-designed COVID-19 pandemic questionnaire, the Stress and Coping Inventory (SCI), the National Comprehensive Cancer Network® (NCCN®) Distress Thermometer (DT), the European Organization for Research and Treatment of Cancer (EORTC) QLQ C30, and the BR23. Results Eighty-two breast cancer patients were included. Therapy status and social demographic factors did not have a significant effect on the distress caused by the COVID-19 pandemic. The results of the DT pre and during COVID-19 pandemic did not differ significantly. Using the self-designed COVID-19 pandemic questionnaire, we detected three distinct subgroups demonstrating different levels of concerns in relation to SARS-CoV-2. The subgroup with the highest levels of concern reported significantly decreased life quality, related parameters and symptoms. Conclusions This monocentric study demonstrated that the COVID-19 pandemic significantly affected psychological health in a subpopulation of breast cancer patients. The application of a self-created “COVID-19 pandemic questionnaire” could potentially be used to help identify breast cancer patients who are susceptible to increased psychological distress due to the COVID-19 pandemic, and therefore may need additional intensive psychological support. Trial registration DRKS-ID: DRKS00022507.

Family functioning and psychological distress among Japanese breast cancer patients and families

2005 ◽  
Vol 13 (12) ◽  
pp. 1044-1050 ◽  
Author(s):  
Shuichi Ozono ◽  
Toshinari Saeki ◽  
Shinichi Inoue ◽  
Tomoyuki Mantani ◽  
Hitoshi Okamura ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Psychological Distress ◽  
Family Functioning ◽  
Cancer Patients ◽  
Breast Cancer Patients
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