scholarly journals Interacting Effect of Catechol-O-Methyltransferase (COMT) and Monoamine Oxidase A (MAOA) Gene Polymorphisms, and Stressful Life Events on Aggressive Behavior in Chinese Male Adolescents

2018 ◽  
Vol 9 ◽  
Author(s):  
Meiping Wang ◽  
Hailei Li ◽  
Kirby Deater-Deckard ◽  
Wenxin Zhang
Keyword(s):  
Monoamine Oxidase ◽  
Aggressive Behavior ◽  
Life Events ◽  
Gene Polymorphisms ◽  
Stressful Life Events ◽  
Monoamine Oxidase A ◽  
Stressful Life ◽  
Male Adolescents ◽  
Maoa Gene ◽  
Chinese Male

scholarly journals Association of Monoamine Oxidase A (MAOA) Gene uVNTR and rs6323 Polymorphisms with Attention Deficit and Hyperactivity Disorder in Korean Children

Medicina ◽  
2018 ◽  
Vol 54 (3) ◽  
pp. 32 ◽  
Author(s):  
In Hwang ◽  
Myung Lim ◽  
Ho Kwon ◽  
Han Jin
Keyword(s):  
Attention Deficit Hyperactivity Disorder ◽  
Monoamine Oxidase ◽  
Attention Deficit ◽  
Gene Polymorphisms ◽  
Rating Scales ◽  
Assessment System ◽  
Monoamine Oxidase A ◽  
Korean Children ◽  
Hyperactivity Disorder ◽  
Maoa Gene

Objective: Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. The genetic cause of ADHD is still unclear, but the dopaminergic, serotonergic, and noradrenergic pathways have shown a strong association. In particular, monoamine oxidase A (MAOA) plays an important role in the catabolism of these neurotransmitters, suggesting that the MAOA gene is associated with ADHD. Therefore, we evaluated the relationship between the MAOA gene polymorphisms (uVNTR and rs6323) and ADHD. Materials and methods: We collected a total of 472 Korean children (150 ADHD cases and 322 controls) using the Korean version of the Dupaul Attention Deficit Hyperactivity Disorder Rating Scales (K-ARS). Genotyping was performed by PCR and PCR-RFLP. The Behavior Assessment System for Children Second Edition (BASC-2) was used to evaluate the problem behaviors within ADHD children. Results: We observed significant associations between the rs6323 and ADHD in girls (p < 0.05) and the TT genotype was observed as a protective factor against ADHD in the recessive model (OR 0.31, 95% CI 0.100–0.950, p = 0.022). The 3.5R-G haplotype showed a significant association in ADHD boys (p = 0.043). The analysis of subtype also revealed that the 4.5R allele of uVNTR was a risk factor for the development of ADHD in the combined symptom among girls (OR 1.87, 95% CI 1.014–3.453, p = 0.031). In the BASC-2 analysis, the MAOA uVNTR polymorphism was associated with activities of daily living in ADHD boys (p = 0.017). Conclusion: These results suggest the importance of the MAOA gene polymorphisms in the development of ADHD in Korean children. A larger sample set and functional studies are required to further elucidate of our findings.

Anxiety, depression and stressful life events among medical students: a prospective study in Antalya, Turkey

2001 ◽  
Vol 35 (1) ◽  
pp. 12-17 ◽  
Author(s):  
Mehmet Aktekin ◽  
Taha Karaman ◽  
Yesim Yigiter Senol ◽  
Sukru Erdem ◽  
Hakan Erengin ◽  
...  
Keyword(s):  
Medical Students ◽  
Prospective Study ◽  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
A Prospective Study ◽  
Anxiety Depression

Stressful life events in pregnancy and head circumference at birth

2003 ◽  
Vol 45 (12) ◽  
Author(s):  
Carsten Obel ◽  
Morten Hedegaard ◽  
Tine Brink Henriksen ◽  
Niels Jørgen Secher ◽  
Jørn Olsen
Keyword(s):  
Life Events ◽  
Head Circumference ◽  
Stressful Life Events ◽  
Stressful Life ◽  
In Pregnancy

Assessment of Positive and Negative Change Following Stressful Life Events

2006 ◽  
Author(s):  
Jennifer L. Schuster ◽  
Donald Edmondson ◽  
Crystal L. Park ◽  
Matthew Wachen ◽  
Shauna L. Clen
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life ◽  
Negative Change

What is first? Stressful life events, negative well-being or sickness absenteeism?

2002 ◽  
Author(s):  
T. van Vuuren ◽  
S. van der Heuvel ◽  
S. Andriessen ◽  
P. Smulders ◽  
P. Bongers
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Well Being ◽  
Stressful Life ◽  
Sickness Absenteeism

Hoarding Linked to Traumatic and Stressful Life Events

2011 ◽  
Author(s):  
D. Landau ◽  
A. C. Iervolino ◽  
A. Pertusa ◽  
S. Santo ◽  
S. Singh ◽  
...  
Keyword(s):  
Life Events ◽  
Stressful Life Events ◽  
Stressful Life
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