scholarly journals Suppressor of Gamma Response 1 Modulates the DNA Damage Response and Oxidative Stress Response in Leaves of Cadmium-Exposed Arabidopsis thaliana

2020 ◽  
Vol 11 ◽  
Author(s):  
Sophie Hendrix ◽  
Verena Iven ◽  
Thomas Eekhout ◽  
Michiel Huybrechts ◽  
Ingeborg Pecqueur ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Arabidopsis Thaliana ◽  
Stress Response ◽  
Dna Damage Response ◽  
Oxidative Stress Response ◽  
Damage Response ◽  
And Oxidative Stress

The crosstalk between trace elements with DNA damage response, repair, and oxidative stress in cancer

2018 ◽  
Vol 120 (2) ◽  
pp. 1080-1105 ◽  
Author(s):  
Sadra Samavarchi Tehrani ◽  
Hamideh Mahmoodzadeh Hosseini ◽  
Tooba Yousefi ◽  
Maryam Abolghasemi ◽  
Durdi Qujeq ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Trace Elements ◽  
Dna Damage Response ◽  
Damage Response ◽  
And Oxidative Stress

Crosstalk between Phosphoinositide 3‐kinase/Akt signaling pathway with DNA damage response and oxidative stress in cancer

2018 ◽  
Vol 120 (6) ◽  
pp. 10248-10272 ◽  
Author(s):  
Ansar Karimian ◽  
Sayed Mostafa Mir ◽  
Hadi Parsian ◽  
Sona Refieyan ◽  
Mohammad Mirza‐Aghazadeh‐Attari ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Signaling Pathway ◽  
Dna Damage Response ◽  
Akt Signaling ◽  
Akt Signaling Pathway ◽  
Damage Response ◽  
Phosphoinositide 3 Kinase ◽  
And Oxidative Stress

scholarly journals Dual targeting of the DNA damage response pathway and BCL-2 in diffuse large B-cell lymphoma

Leukemia ◽  
2021 ◽  
Author(s):  
Alessandra Rossi ◽  
Stefania Orecchioni ◽  
Paolo Falvo ◽  
Valentina Tabanelli ◽  
Elena Baiardi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Dna Damage Response ◽  
Poor Prognosis ◽  
Cell Lymphoma ◽  
B Cell Lymphoma ◽  
Large B Cell Lymphoma ◽  
Damage Response ◽  
And Oxidative Stress ◽  
Large B Cell

AbstractStandard chemotherapies for diffuse large B-cell lymphoma (DLBCL), based on the induction of exogenous DNA damage and oxidative stress, are often less effective in the presence of increased MYC and BCL-2 levels, especially in the case of double hit (DH) lymphomas harboring rearrangements of the MYC and BCL-2 oncogenes, which enrich for a patient’s population characterized by refractoriness to anthracycline-based chemotherapy. Here we hypothesized that adaptive mechanisms to MYC-induced replicative and oxidative stress, consisting in DNA damage response (DDR) activation and BCL-2 overexpression, could represent the biologic basis of the poor prognosis and chemoresistance observed in MYC/BCL-2-positive lymphoma. We first integrated targeted gene expression profiling (T-GEP), fluorescence in situ hybridization (FISH) analysis, and characterization of replicative and oxidative stress biomarkers in two independent DLBCL cohorts. The presence of oxidative DNA damage biomarkers identified a poor prognosis double expresser (DE)-DLBCL subset, characterized by relatively higher BCL-2 gene expression levels and enrichment for DH lymphomas. Based on these findings, we tested therapeutic strategies based on combined DDR and BCL-2 inhibition, confirming efficacy and synergistic interactions in in vitro and in vivo DH-DLBCL models. These data provide the rationale for precision-therapy strategies based on combined DDR and BCL-2 inhibition in DH or DE-DLBCL.

Metformin inhibits the inflammatory and oxidative stress response induced by skin UVB-irradiation and provides 4-hydroxy-2-nonenal and nitrotyrosine formation and p53 protein activation

2020 ◽  
Vol 100 (2) ◽  
pp. 152-155
Author(s):  
Fernando Pinheiro Souza-Neto ◽  
Poliana Camila Marinello ◽  
Gabriela Pasqual Melo ◽  
Leandra Zambeli Naira Ramalho ◽  
Eliana M. Cela ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Stress Response ◽  
P53 Protein ◽  
Oxidative Stress Response ◽  
Uvb Irradiation ◽  
Protein Activation ◽  
And Oxidative Stress

scholarly journals DNA Damage Response and Oxidative Stress in Systemic Autoimmunity

2019 ◽  
Vol 21 (1) ◽  
pp. 55 ◽  
Author(s):  
Vassilis L. Souliotis ◽  
Nikolaos I. Vlachogiannis ◽  
Maria Pappa ◽  
Alexandra Argyriou ◽  
Panagiotis A. Ntouros ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Immune Response ◽  
Dna Damage ◽  
Autoimmune Diseases ◽  
Dna Damage Response ◽  
Lupus Erythematosus ◽  
Mononuclear Cells ◽  
Tissue Injury ◽  
Systemic Autoimmune Diseases ◽  
Damage Response

The DNA damage response and repair (DDR/R) network, a sum of hierarchically structured signaling pathways that recognize and repair DNA damage, and the immune response to endogenous and/or exogenous threats, act synergistically to enhance cellular defense. On the other hand, a deregulated interplay between these systems underlines inflammatory diseases including malignancies and chronic systemic autoimmune diseases, such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis. Patients with these diseases are characterized by aberrant immune response to self-antigens with widespread production of autoantibodies and multiple-tissue injury, as well as by the presence of increased oxidative stress. Recent data demonstrate accumulation of endogenous DNA damage in peripheral blood mononuclear cells from these patients, which is related to (a) augmented DNA damage formation, at least partly due to the induction of oxidative stress, and (b) epigenetically regulated functional abnormalities of fundamental DNA repair mechanisms. Because endogenous DNA damage accumulation has serious consequences for cellular health, including genomic instability and enhancement of an aberrant immune response, these results can be exploited for understanding pathogenesis and progression of systemic autoimmune diseases, as well as for the development of new treatments.

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