A Snapshot of Functional Genetic Studies in Medicago truncatula

The inheritance has been studied of three morphological characters which could be used as markers in the "pure seed" certification of commercial varieties of barrel medic, M. truncatula Gaertn. The leaf anthocyanin pigmentation pattern, as found in accession No. 2829, and the clockwise form of pod coiling characterizing accession No. 3309, are determined by single dominant genes. The spineless character of the pod of accession No. 2822 is due to a recessive gene. The simple inheritance of these characters and the complete penetrance of the genes concerned indicate that the anthocyanin marker and the spineless pod could be used for certification. Since the clockwise-anticlockwise pattern of coiling occurs in both forms in commercial barrel medic varieties, it is likely to be useful only as a marker in genetic studies. Details are given of a satisfactory procedure developed for crossing medic varieties

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A snapshot of functional genetic studies in Medicago truncatula

The Model Legume Medicago truncatula ◽

10.1002/9781119409144.ch02 ◽

2019 ◽

pp. 7-30

Author(s):

Yun Kang ◽

Minguye Li ◽

Senjuti Sinharoy ◽

Jerome Verdier

Keyword(s):

Medicago Truncatula ◽

Genetic Studies

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Moving beyond the “LDL hypothesis”

VASA ◽

10.1024/0301-1526/a000451 ◽

2015 ◽

Vol 44 (5) ◽

pp. 333-340 ◽

Cited By ~ 7

Author(s):

Christian Werner ◽

Ulrich Laufs

Keyword(s):

Ldl Cholesterol ◽

Causal Relation ◽

Low Density Lipoprotein ◽

Density Lipoprotein ◽

Clinical Trial Data ◽

Randomised Clinical Trial ◽

Trial Data ◽

Low Density Lipoprotein Cholesterol ◽

Genetic Studies ◽

Statin Drug

Abstract. Summary: The term “LDL hypothesis” is frequently used to describe the association of low-density lipoprotein cholesterol (LDL-cholesterol, LDL-C) and cardiovascular (CV) events. Recent data from genetic studies prove a causal relation between serum LDL-C and CV events. These data are in agreement with mechanistic molecular studies and epidemiology. New randomised clinical trial data show that LDL-C lowering with statins and a non-statin drug, ezetimibe, reduces CV events. We therefore believe that the “LDL-hypothesis” has been proven; the term appears to be outdated and should be replaced by “LDL causality”.

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Supplemental Material for Heritability of Personality: A Meta-Analysis of Behavior Genetic Studies

Psychological Bulletin ◽

10.1037/bul0000017.supp ◽

2015 ◽

Keyword(s):

Meta Analysis ◽

Behavior Genetic ◽

Genetic Studies

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Neuropsychological intermediate phenotypes as tools for genetic studies in schizophrenia

Pharmacopsychiatry ◽

10.1055/s-0029-1240156 ◽

2009 ◽

Vol 42 (05) ◽

Author(s):

H Konnerth ◽

I Giegling ◽

AM Hartmann ◽

J Genius ◽

A Ruppert ◽

...

Keyword(s):

Genetic Studies ◽

Intermediate Phenotypes

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The Use of Medical Record Linkage for Population and Genetic Studies

Methods of Information in Medicine ◽

10.1055/s-0038-1635962 ◽

1969 ◽

Vol 08 (01) ◽

pp. 07-11 ◽

Cited By ~ 9

Author(s):

H. B. Newcombe

Keyword(s):

Record Linkage ◽

Large Scale ◽

Medical Record Linkage ◽

Canadian Province ◽

Genetic Studies ◽

Parental Characteristics ◽

Family Histories ◽

The Family ◽

Large Populations ◽

Machine Readable

Methods are described for deriving personal and family histories of birth, marriage, procreation, ill health and death, for large populations, from existing civil registrations of vital events and the routine records of ill health. Computers have been used to group together and »link« the separately derived records pertaining to successive events in the lives of the same individuals and families, rapidly and on a large scale. Most of the records employed are already available as machine readable punchcards and magnetic tapes, for statistical and administrative purposes, and only minor modifications have been made to the manner in which these are produced.As applied to the population of the Canadian province of British Columbia (currently about 2 million people) these methods have already yielded substantial information on the risks of disease: a) in the population, b) in relation to various parental characteristics, and c) as correlated with previous occurrences in the family histories.

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