scholarly journals Proteomic Dissection of Endosperm Starch Granule Associated Proteins Reveals a Network Coordinating Starch Biosynthesis and Amino Acid Metabolism and Glycolysis in Rice Endosperms

2016 ◽  
Vol 7 ◽  
Author(s):  
Huatao Yu ◽  
Tai Wang
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Starch Granule ◽  
Starch Biosynthesis ◽  
Associated Proteins ◽  
Endosperm Starch

Multi-omics reveals a relationship between endometrial amino acid metabolism and autophagy in women with recurrent miscarriage

2021 ◽  
Author(s):  
Ling Hong ◽  
Yuan chang Zhu ◽  
Su Liu ◽  
Tonghua Wu ◽  
Yuye Li ◽  
...  
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism ◽  
Recurrent Miscarriage ◽  
Normal Pregnancy ◽  
Beclin 1 ◽  
Endometrial Stromal Cells ◽  
Associated Proteins ◽  
Glutamine Deprivation ◽  
Related Proteins

Abstract Deterioration of the endometrial environment is an essential cause of recurrent miscarriage (RM). However, current studies in terms of endometrial amino acid metabolic characterization and autophagy are still inadequate. This study aimed to assess differences in the endometrial amino acid metabolism and autophagy between normal pregnant and RM women to reveal the association between amino acid metabolism, autophagy, and the endometrial microenvironment. We tried to (1) identify the alternation in metabolite profiles in the RM endometrium; (2) investigate the expression of autophagy-related proteins in RM; (3) elucidate the association between amino acid metabolism and autophagy in RM. Our results showed that glutamine metabolites were upregulated while glutamate metabolites were downregulated in the endometrium of RM women. The levels of autophagy-associated proteins, including LC3B, ATG12, and Beclin-1, were significantly higher in the endometrium of RM women. Hemostasis, autophagy and IFNα signaling were the top three differentially activated signaling pathways between women with RM and normal pregnancy. Interestingly, we also found that the expression of AMPK and GCN2 was significantly up-regulated in the endometrium of women with RM, and the same expression trend was also observed in the human endometrial stromal cells cultured in glutamine deprivation medium. Furthermore, inhibition of AMPK decreased the level of GCN2, indicating a positive correlation between GCN2 and AMPK. The expression of GCN2 was consistent with the expression of ATG12 and beclin-1; however, it was opposite to that of p62. Exposure to glutamine deprivation increased the level of LC3B, GCN2, ATG12 and beclin-1. Altogether, these findings suggested significant crosstalk between amino acid metabolism and autophagy. In summary, our data suggested that aberrant crosstalk between amino acid metabolism and autophagy may contribute to the impaired endometrial microenvironment of RM. Our study may provide new insight into the diagnosis of recurrent miscarriage due to endometrial factors.

Amino Acid Metabolism

1979 ◽  
Vol 7 (1) ◽  
pp. 261-262
Author(s):  
E. V. ROWSELL
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Effect of intravenous bicarbonate administration on postoperative amino acid metabolism

1985 ◽  
Vol 4 ◽  
pp. 141-146 ◽  
Author(s):  
K VESTERBERG ◽  
J BERGSTROM ◽  
P FURST ◽  
U LEANDER ◽  
E VINNARS
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism

Different sensitivity of glucose and amino acid metabolism to insulin in NIDDM

Diabetes ◽  
1993 ◽  
Vol 42 (12) ◽  
pp. 1868-1877 ◽  
Author(s):  
L. Luzi ◽  
A. S. Petrides ◽  
R. A. De Fronzo
Keyword(s):  
Amino Acid ◽  
Amino Acid Metabolism ◽  
Acid Metabolism
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