scholarly journals Tyrosine Phosphorylation Based Homo-dimerization of Arabidopsis RACK1A Proteins Regulates Oxidative Stress Signaling Pathways in Yeast

2016 ◽  
Vol 7 ◽  
Author(s):  
Mercy Sabila ◽  
Nabanita Kundu ◽  
Deana Smalls ◽  
Hemayet Ullah
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Tyrosine Phosphorylation ◽  
Stress Signaling

Vitamin E synthetic derivate—TPGS—selectively induces apoptosis in jurkat t cells via oxidative stress signaling pathways: implications for acute lymphoblastic leukemia

APOPTOSIS ◽  
2016 ◽  
Vol 21 (9) ◽  
pp. 1019-1032 ◽  
Author(s):  
Cristian Ruiz-Moreno ◽  
Marlene Jimenez-Del-Rio ◽  
Ligia Sierra-Garcia ◽  
Betty Lopez-Osorio ◽  
Carlos Velez-Pardo
Keyword(s):  
Oxidative Stress ◽  
T Cells ◽  
Vitamin E ◽  
Acute Lymphoblastic Leukemia ◽  
Signaling Pathways ◽  
Lymphoblastic Leukemia ◽  
Stress Signaling ◽  
Jurkat T Cells

Acute lysine overload provokes marked striatum injury involving oxidative stress signaling pathways in glutaryl-CoA dehydrogenase deficient mice

2019 ◽  
Vol 129 ◽  
pp. 104467 ◽  
Author(s):  
Alexandre Umpierrez Amaral ◽  
Bianca Seminotti ◽  
Janaína Camacho da Silva ◽  
Francine Hehn de Oliveira ◽  
Rafael Teixeira Ribeiro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Stress Signaling ◽  
Deficient Mice

scholarly journals The Role of Serine-Threonine Protein Phosphatase PP2A in Plant Oxidative Stress Signaling—Facts and Hypotheses

2019 ◽  
Vol 20 (12) ◽  
pp. 3028 ◽  
Author(s):  
Csaba Máthé ◽  
Tamás Garda ◽  
Csongor Freytag ◽  
Márta M-Hamvas
Keyword(s):  
Oxidative Stress ◽  
Signaling Pathways ◽  
Protein Phosphatase ◽  
Protein Phosphatases ◽  
Crop Improvement ◽  
Regulatory Function ◽  
Future Research ◽  
Stress Signaling ◽  
Ros Signaling ◽  
External Signals

Abiotic and biotic factors induce oxidative stress involving the production and scavenging of reactive oxygen species (ROS). This review is a survey of well-known and possible roles of serine-threonine protein phosphatases in plant oxidative stress signaling, with special emphasis on PP2A. ROS mediated signaling involves three interrelated pathways: (i) perception of extracellular ROS triggers signal transduction pathways, leading to DNA damage and/or the production of antioxidants; (ii) external signals induce intracellular ROS generation that triggers the relevant signaling pathways and (iii) external signals mediate protein phosphorylation dependent signaling pathway(s), leading to the expression of ROS producing enzymes like NADPH oxidases. All pathways involve inactivation of serine-threonine protein phosphatases. The metal dependent phosphatase PP2C has a negative regulatory function during ABA mediated ROS signaling. PP2A is the most abundant protein phosphatase in eukaryotic cells. Inhibitors of PP2A exert a ROS inducing activity as well and we suggest that there is a direct relationship between these two effects of drugs. We present current findings and hypotheses regarding PP2A-ROS signaling connections related to all three ROS signaling pathways and anticipate future research directions for this field. These mechanisms have implications in the understanding of stress tolerance of vascular plants, having applications regarding crop improvement.

Calcium sensors and their stress signaling pathways in plants

2013 ◽  
Vol 35 (7) ◽  
pp. 875-884 ◽  
Author(s):  
Zhong-Zhong ZHENG ◽  
Jin-Qiu SHEN ◽  
Wei-Huai PAN ◽  
Jian-Wei PAN
Keyword(s):  
Signaling Pathways ◽  
Stress Signaling ◽  
Calcium Sensors

scholarly journals MicroRNAs and Oxidative Stress: An Intriguing Crosstalk to Be Exploited in the Management of Type 2 Diabetes

Antioxidants ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 802
Author(s):  
Teresa Vezza ◽  
Aranzazu M. de Marañón ◽  
Francisco Canet ◽  
Pedro Díaz-Pozo ◽  
Miguel Marti ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Type 2 Diabetes ◽  
Signaling Pathways ◽  
Current Knowledge ◽  
Critical Role ◽  
Cell Dysfunction ◽  
Non Coding Rnas ◽  
And Oxidative Stress ◽  
Molecular Crosstalk

Type 2 diabetes is a chronic disease widespread throughout the world, with significant human, social, and economic costs. Its multifactorial etiology leads to persistent hyperglycemia, impaired carbohydrate and fat metabolism, chronic inflammation, and defects in insulin secretion or insulin action, or both. Emerging evidence reveals that oxidative stress has a critical role in the development of type 2 diabetes. Overproduction of reactive oxygen species can promote an imbalance between the production and neutralization of antioxidant defence systems, thus favoring lipid accumulation, cellular stress, and the activation of cytosolic signaling pathways, and inducing β-cell dysfunction, insulin resistance, and tissue inflammation. Over the last few years, microRNAs (miRNAs) have attracted growing attention as important mediators of diverse aspects of oxidative stress. These small endogenous non-coding RNAs of 19–24 nucleotides act as negative regulators of gene expression, including the modulation of redox signaling pathways. The present review aims to provide an overview of the current knowledge concerning the molecular crosstalk that takes place between oxidative stress and microRNAs in the physiopathology of type 2 diabetes, with a special emphasis on its potential as a therapeutic target.

A polysaccharide of PFP-1 from Pleurotus geesteranus attenuates alcoholic liver diseases via Nrf2 and NF-κB signaling pathways

2021 ◽  
Author(s):  
Xinling Song ◽  
Wenxue Sun ◽  
Wenxin Cai ◽  
Le Jia ◽  
Jianjun Zhang
Keyword(s):  
Oxidative Stress ◽  
Liver Disease ◽  
Liver Injury ◽  
Signaling Pathways ◽  
Alcoholic Liver Disease ◽  
Fruiting Body ◽  
Liver Diseases ◽  
Alcoholic Liver Diseases

A polysaccharide named as PFP-1 was isolated from Pleurotus geesteranus fruiting body, and the potential investigations on ameliorating oxidative stress and liver injury against alcoholic liver disease (ALD) were processed...

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