scholarly journals Investigation of the Sympathetic Regulation in Delayed Onset Muscle Soreness: Results of an RCT

2021 ◽  
Vol 12 ◽  
Author(s):  
Johannes Fleckenstein ◽  
Elmo W. I. Neuberger ◽  
Philipp Bormuth ◽  
Fabio Comes ◽  
Angelika Schneider ◽  
...  
Keyword(s):  
Muscle Soreness ◽  
Inflammatory Marker ◽  
Stellate Ganglion ◽  
Pressure Pain Threshold ◽  
Stellate Ganglion Block ◽  
Delayed Onset Muscle Soreness ◽  
Eccentric Load ◽  
Delayed Onset ◽  
Sympathetic Regulation ◽  
Exercise Induced

Sports-related pain and injury is directly linked to tissue inflammation, thus involving the autonomic nervous system (ANS). In the present experimental study, we disable the sympathetic part of the ANS by applying a stellate ganglion block (SGB) in an experimental model of delayed onset muscle soreness (DOMS) of the biceps muscle. We included 45 healthy participants (female 11, male 34, age 24.16 ± 6.67 years [range 18–53], BMI 23.22 ± 2.09 kg/m2) who were equally randomized to receive either (i) an SGB prior to exercise-induced DOMS (preventive), (ii) sham intervention in addition to DOMS (control/sham), or (iii) SGB after the induction of DOMS (rehabilitative). The aim of the study was to determine whether and to what extent sympathetically maintained pain (SMP) is involved in DOMS processing. Focusing on the muscular area with the greatest eccentric load (biceps distal fifth), a significant time × group interaction on the pressure pain threshold was observed between preventive SGB and sham (p = 0.034). There was a significant effect on pain at motion (p = 0.048), with post hoc statistical difference at 48 h (preventive SGB Δ1.09 ± 0.82 cm VAS vs. sham Δ2.05 ± 1.51 cm VAS; p = 0.04). DOMS mediated an increase in venous cfDNA -as a potential molecular/inflammatory marker of DOMS- within the first 24 h after eccentric exercise (time effect p = 0.018), with a peak at 20 and 60 min. After 60 min, cfDNA levels were significantly decreased comparing preventive SGB to sham (unpaired t-test p = 0.008). At both times, 20 and 60 min, cfDNA significantly correlated with observed changes in PPT. The 20-min increase was more sensitive, as it tended toward significance at 48 h (r = 0.44; p = 0.1) and predicted the early decrease of PPT following preventive stellate blocks at 24 h (r = 0.53; p = 0.04). Our study reveals the broad impact of the ANS on DOMS and exercise-induced pain. For the first time, we have obtained insights into the sympathetic regulation of pain and inflammation following exercise overload. As this study is of a translational pilot character, further research is encouraged to confirm and specify our observations.

scholarly journals El masaje en la prevención y tratamiento del dolor muscular tardío: una revisión sistemática actualizada

2019 ◽  
Vol 6 (3) ◽  
pp. 38
Author(s):  
R Candia Luján ◽  
RA Paredes Carrera ◽  
O Costa Moreira ◽  
KF Candia Sosa ◽  
JA De Paz Fernández
Keyword(s):  
Muscle Damage ◽  
Muscle Soreness ◽  
Web Of Science ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset ◽  
Palabras Clave ◽  
Revisión Sistemática ◽  
Exercise Induced

El masaje es una de las terapias más utilizadas para aliviar el dolor muscular tardío (DMT). El objetivo del presente estudio fue determinar la efectividad del masaje en el tratamiento del DMT, para lo cual se llevó a cabo una revisión sistemática en las bases de datos, Pubmed, Scopus, SportDiscus, Web of Science y el buscador Google académico, usando las palabras clave delayed onset muscle soreness y exercise induced muscle damage combinado con massage. Se incluyeron en el estudio 23 artículos en los cuales el 78% mostró disminución del DMT mientras que en el restante 22% no hubo mejoras o bien empeoró. El análisis de los estudios permite concluir que el masaje es una terapia efectiva en el tratamiento del dolor muscular tardío.

scholarly journals Effects of Deep Oscillation Therapy on Symptoms Associated with Eccentric Exercise-Induced Delayed Onset Muscle Soreness

2019 ◽  
Vol 51 (Supplement) ◽  
pp. 823
Author(s):  
Kacey Ohlemeyer ◽  
Steele Morris ◽  
Heriberto Zamora ◽  
Allison B. Smith ◽  
Dawn M. Emerson ◽  
...  
Keyword(s):  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset ◽  
Exercise Induced

Role of S100A12/RAGE axis in eccentric exercise-induced delayed-onset muscle soreness in male non-athletes

2015 ◽  
Vol 11 (3) ◽  
pp. 345-349 ◽  
Author(s):  
Hossein Khorramdelazad ◽  
Hadi Rohani ◽  
Abdollah Jafarzadeh ◽  
Mohammadreza Hajizadeh ◽  
Gholamhossein Hassanshahi
Keyword(s):  
Eccentric Exercise ◽  
Muscle Soreness ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset ◽  
Exercise Induced

scholarly journals Range of Motion as a Predictor of Clinical Shoulder Pain During Recovery From Delayed-Onset Muscle Soreness

2015 ◽  
Vol 50 (3) ◽  
pp. 289-294 ◽  
Author(s):  
Kelly A. Larkin-Kaiser ◽  
Jeffrey J. Parr ◽  
Paul A. Borsa ◽  
Steven Z. George
Keyword(s):  
Range Of Motion ◽  
Internal Rotation ◽  
Functional Recovery ◽  
Muscle Soreness ◽  
External Rotation ◽  
Delayed Onset Muscle Soreness ◽  
Delayed Onset ◽  
Active Flexion ◽  
Exercise Induced ◽  
Active Abduction

Context: Athletic trainers use clinical pain and range of motion (ROM) to gauge recovery after musculoskeletal injury. Limited evidence to date suggests which shoulder ROM measures can predict symptomatic relief and functional recovery after delayed-onset muscle soreness (DOMS). Objective: To determine whether shoulder passive internal rotation, passive external rotation, active abduction, and active flexion and evoked pain with abduction are associated with resting pain experienced after exercise-induced DOMS. Design: Descriptive laboratory study. Setting: Controlled research laboratory. Patients or Other Participants: A total of 110 healthy, right-hand–dominant participants (44 men: age = 25.39 ± 7.00 years, height = 178.93 ± 7.01 cm, weight = 78.59 ± 14.04 kg; 66 women: age = 22.98 ± 6.11 years, height = 164.64 ± 6.94 cm, weight = 61.86 ± 11.67 kg). Intervention(s): Participants completed an exercise-induced DOMS protocol for the external rotators of the dominant shoulder to replicate muscle injury. Main Outcome Measure(s): Current resting pain was assessed daily for 96 hours using the Brief Pain Inventory. We evaluated functional recovery with measures of ROM in abduction, internal rotation, external rotation, and flexion. Evoked pain with active abduction was reported, and the pain rating served as the dependent variable in the regression model. Results: Impairment measures explained resting pain at 48 (R2 = 0.392) and 96 hours (R2 = 0.164). Abduction and internal-rotation ROM and evoked pain with abduction predicted resting pain at 48 hours (P < .001). At 96 hours, evoked pain with abduction of the injured arm (P < .001) was the significant contributor to resting pain. Conclusions: These models suggest that resting pain after experimentally induced DOMS occurs at 48 hours and is associated with specific ranges of motion and evoked pain with abduction.

scholarly journals Branched-Chain Amino Acid Plus Glucose Supplement Reduces Exercise-Induced Delayed Onset Muscle Soreness in College-Age Females

2013 ◽  
Vol 2013 ◽  
pp. 1-5 ◽  
Author(s):  
Danielle T. Leahy ◽  
Stephen J. Pintauro
Keyword(s):  
Muscle Soreness ◽  
Muscle Protein ◽  
Muscle Protein Synthesis ◽  
Recovery Period ◽  
Delayed Onset Muscle Soreness ◽  
Male And Female ◽  
Delayed Onset ◽  
Branched Chain ◽  
Exercise Induced ◽  
Female Subjects

Supplementation with branched-chain amino acids (BCAAs) has been used to stimulate muscle protein synthesis following exercise. The purpose of this study was to determine if supplementation with BCAAs in combination with glucose would reduce exercise-induced delayed onset muscle soreness (DOMS). Using a double-blind crossover design, 20 subjects (11 females, 9 males) were randomly assigned to either BCAA () or placebo () groups. Subjects performed a squatting exercise to elicit DOMS and rated their muscle soreness every 24 hours for four days following exercise while continuing to consume the BCAA or placebo. Following a three-week recovery period, subjects returned and received the alternate BCAA or placebo treatment, repeating the same exercise and DOMS rating protocol for the next four days. BCAA supplementation in female subjects resulted in a significant decrease in DOMS versus placebo at 24 hours following exercise (). No significant effect of BCAA supplementation versus placebo was noted in male subjects nor when male and female results were analyzed together. This gender difference may be related to dose per body weight differences between male and female subjects.

scholarly journals Effect of curcumin supplement or placebo in delayed onset muscle soreness: a systematic review and meta-analysis

2021 ◽  
Vol 45 (1) ◽  
Author(s):  
Natthanichar Rattanaseth ◽  
Patteera Panyarapeepat ◽  
Janisa Andrea Muljadi ◽  
Kornkit Chaijenkij ◽  
Jatupon Kongtharvonskul
Keyword(s):  
Muscle Soreness ◽  
Meta Analysis ◽  
Delayed Onset Muscle Soreness ◽  
Main Body ◽  
Level Of Evidence ◽  
Post Exercise ◽  
Multiple Strategies ◽  
Delayed Onset ◽  
Tnf Α ◽  
Exercise Induced

Abstract Background There are multiple strategies that have been suggested to attenuate delayed onset muscle soreness (DOMS). Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation. However, currently, there is still controversy. Main body of the abstract We conduct this meta-analysis according to the PRISMA guidelines. Relevant studies were included from Medline and Scopus from the date of inception to May 04th, 2021 that reported VAS score, blood markers (creatinine kinese (CK), tumor necrotic factor (TNF)-α and interleukin (IL)-6) and range of motion of either group. There were total of 13 studies including 202 and 176 persons in curcumin and placebo group. The unstandardized mean difference (UMD) of VAS muscle soreness in post-exercise, 1, 2, 3 and 4 days was − 0.12 (95% CI − 0.46, 0.22), − 0.38 (− 0.83, 0.08), − 0.67 (− 1.19, − 0.16), − 0.86 (− 1.38, − 0.34), − 0.81 (− 1.27, − 036) and − 1.24 (− 1.50, − 0.99) scores lower in curcumin when compared to placebo. The UMD of CK was − 11.07 (95% CI − 24, 1.86), − 37.51 (− 68.04, − 6.97), − 45.40 (− 95.67, 4.86), − 53.33 (− 128.11, 21.45), − 90.98 (− 173.45, − 8.51) and 117.84 (− 338.69, 574.37) lower in curcumin when compared to placebo. No statistically significantly differences were noted for IL-6, TNF-α and ROM between two groups. Short conclusion This meta-analysis suggested that curcumin supplement reduced delayed onset muscle soreness and CK after exercise in 1, 2, 3, and 4 days when compared to placebo. However, TNF and IL were not affected by curcumin ingestion. Level of evidence I.

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