scholarly journals Commentary: Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease (DIILD) Induced by Bleomycin

2021 ◽  
Vol 12 ◽  
Author(s):  
Sotirios I. Sinis ◽  
Sotirios G. Zarogiannis
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Rat Model ◽  
Imaging Biomarkers ◽  
Drug Induced

scholarly journals Imaging Biomarkers and Pathobiological Profiling in a Rat Model of Drug-Induced Interstitial Lung Disease Induced by Bleomycin

2020 ◽  
Vol 11 ◽  
Author(s):  
Irma Mahmutovic Persson ◽  
Hanna Falk Håkansson ◽  
Anders Örbom ◽  
Jian Liu ◽  
Karin von Wachenfeldt ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Rat Model ◽  
Imaging Biomarkers ◽  
Drug Induced

Biological- and imaging biomarkers of edema and fibrosis in a rat model of drug-induced interstitial lung disease (DIILD)

2019 ◽  
Author(s):  
Irma Mahmutovic Persson ◽  
Hanna Falk Håkansson ◽  
Anders Örbom ◽  
Per-Ola Önnervik ◽  
Janne Persson ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Rat Model ◽  
Imaging Biomarkers ◽  
Drug Induced

scholarly journals Serum Metabolomic Profiles of Rheumatoid Arthritis Patients With Acute-Onset Diffuse Interstitial Lung Disease

2019 ◽  
Vol 14 ◽  
pp. 117727191987047 ◽  
Author(s):  
Hiroshi Furukawa ◽  
Shomi Oka ◽  
Kota Shimada ◽  
Atsushi Hashimoto ◽  
Akiko Komiya ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Stable State ◽  
Area Under The Curve ◽  
Stable Condition ◽  
Hierarchical Cluster ◽  
Acute Onset ◽  
Serum Samples ◽  
Drug Induced

Objective: Acute-onset diffuse interstitial lung disease (AoDILD) includes acute exacerbation of interstitial lung disease (ILD), drug-induced ILD, and Pneumocystis pneumonia, and frequently occurs in patients with rheumatoid arthritis (RA). Since AoDILD causes a poor prognosis in RA, biomarkers for AoDILD were eagerly desired. Metabolomic analyses were extensively performed in cancer patients and successfully generated better diagnostic biomarkers. In the present study, serum metabolomic profiles of AoDILD in RA were investigated to generate better potential metabolomic biomarkers. Methods: Serum samples of 10 RA patients with AoDILD were collected on admission and in a stable state, more than 3 months before the admission. Serum metabolomic analyses were conducted on the samples from these RA patients with AoDILD. Results: Apparently distinct serum metabolomic profiles in AoDILD were not observed in univariate or hierarchical cluster analyses. Partial least squares-discriminant analysis (PLS-DA) was performed to select candidate metabolites based on variable importance in projection (VIP) scores. The PLS-DA model generated from the four metabolites with VIP scores more than 2.25 (mannosamine, alliin, kynurenine, and 2-hydroxybutyric acid) could successfully discriminate AoDILD from the stable condition (area under the curve: 0.962, 95% confidence interval: 0.778–1.000). Conclusion: It was demonstrated that metabolomic profiling was useful to generate better biomarkers in AoDILD.

Cytochrome P450 polymorphisms and drug-induced interstitial lung disease

2011 ◽  
Vol 7 (12) ◽  
pp. 1547-1560 ◽  
Author(s):  
Martin Schwaiblmair ◽  
Werner Behr ◽  
Wolfgang Foerg ◽  
Thomas Berghaus
Keyword(s):  
Cytochrome P450 ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Drug Induced

scholarly journals Drug-Induced Interstitial Lung Disease from a Misdiagnosed Infection

2018 ◽  
Vol 11 ◽  
pp. 117863611879837
Author(s):  
Patrick Twohig ◽  
Jaclyn Rivington
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Drug Induced

scholarly journals Whole genome sequencing to identify predictive markers for the risk of drug-induced interstitial lung disease

PLoS ONE ◽  
2019 ◽  
Vol 14 (10) ◽  
pp. e0223371 ◽  
Author(s):  
Chihiro Udagawa ◽  
Hidehito Horinouchi ◽  
Kouya Shiraishi ◽  
Takashi Kohno ◽  
Takuji Okusaka ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Predictive Markers ◽  
Whole Genome ◽  
Drug Induced

The Spectrum of Drug-Induced Interstitial Lung Disease

2019 ◽  
Vol 8 (4) ◽  
pp. 139-150 ◽  
Author(s):  
Ankush Ratwani ◽  
Bhavik Gupta ◽  
Brian W. Stephenson ◽  
Haresh Mani ◽  
A. Whitney Brown
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Drug Induced

scholarly journals Radiological Patterns of Drug-induced Interstitial Lung Disease (DILD) in Early-phase Oncology Clinical Trials

2020 ◽  
Vol 26 (18) ◽  
pp. 4805-4813
Author(s):  
Angelika Terbuch ◽  
Crescens Tiu ◽  
Irene Moreno Candilejo ◽  
Mariana Scaranti ◽  
Andra Curcean ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Early Phase ◽  
Drug Induced ◽  
Oncology Clinical Trials ◽  
Radiological Patterns
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