scholarly journals The Endothelium as a Therapeutic Target in Diabetes: A Narrative Review and Perspective

2021 ◽  
Vol 12 ◽  
Author(s):  
Jose A. Adams ◽  
Arkady Uryash ◽  
Jose R. Lopez ◽  
Marvin A. Sackner
Keyword(s):  
Physical Activity ◽  
Nitric Oxide ◽  
Current Knowledge ◽  
Salient Feature ◽  
Narrative Review ◽  
Endocrine Function ◽  
Whole Body ◽  
Mortality And Morbidity ◽  
Beneficial Effects ◽  
Intracellular Ca

Diabetes has reached worldwide epidemic proportions, and threatens to be a significant economic burden to both patients and healthcare systems, and an important driver of cardiovascular mortality and morbidity. Improvement in lifestyle interventions (which includes increase in physical activity via exercise) can reduce diabetes and cardiovascular disease mortality and morbidity. Encouraging a population to increase physical activity and exercise is not a simple feat particularly in individuals with co-morbidities (obesity, heart disease, stroke, peripheral vascular disease, and those with cognitive and physical limitations). Translation of the physiological benefits of exercise within that vulnerable population would be an important step for improving physical activity goals and a stopgap measure to exercise. In large part many of the beneficial effects of exercise are due to the introduction of pulsatile shear stress (PSS) to the vascular endothelium. PSS is a well-known stimulus for endothelial homeostasis, and induction of a myriad of pathways which include vasoreactivity, paracrine/endocrine function, fibrinolysis, inflammation, barrier function, and vessel growth and formation. The endothelial cell mediates the balance between vasoconstriction and relaxation via the major vasodilator endothelial derived nitric oxide (eNO). eNO is critical for vasorelaxation, increasing blood flow, and an important signaling molecule that downregulates the inflammatory cascade. A salient feature of diabetes, is endothelial dysfunction which is characterized by a reduction of the bioavailability of vasodilators, particularly nitric oxide (NO). Cellular derangements in diabetes are also related to dysregulation in Ca2+ handling with increased intracellular Ca2+overload, and oxidative stress. PSS increases eNO bioavailability, reduces inflammatory phenotype, decreases intracellular Ca2+ overload, and increases antioxidant capacity. This narrative review and perspective will outline four methods to non-invasively increase PSS; Exercise (the prototype for increasing PSS), Enhanced External Counterpulsation (EECP), Whole Body Vibration (WBV), Passive Simulated Jogging and its predicate device Whole Body Periodic Acceleration, and will discuss current knowledge on their use in diabetes.

scholarly journals Impact of Early Nutrition, Physical Activity and Sleep on the Fetal Programming of Disease in the Pregnancy: A Narrative Review

Nutrients ◽  
2020 ◽  
Vol 12 (12) ◽  
pp. 3900
Author(s):  
Jorge Moreno-Fernandez ◽  
Julio J. Ochoa ◽  
Magdalena Lopez-Frias ◽  
Javier Diaz-Castro
Keyword(s):  
Physical Activity ◽  
Environmental Factors ◽  
Maternal Obesity ◽  
Metabolic Diseases ◽  
Sleep Problems ◽  
Current Knowledge ◽  
Post Partum ◽  
Narrative Review ◽  
Perinatal Complications ◽  
Brain Functions

Early programming is the adaptation process by which nutrition and environmental factors alter development pathways during prenatal growth, inducing changes in postnatal metabolism and diseases. The aim of this narrative review, is evaluating the current knowledge in the scientific literature on the effects of nutrition, environmental factors, physical activity and sleep on development pathways. If in utero adaptations were incorrect, this would cause a mismatch between prenatal programming and adulthood. Adequate caloric intake, protein, mineral, vitamin, and long-chain fatty acids, have been noted for their relevance in the offspring brain functions and behavior. Fetus undernutrition/malnutrition causes a delay in growth and have detrimental effects on the development and subsequent functioning of the organs. Pregnancy is a particularly vulnerable period for the development of food preferences and for modifications in the emotional response. Maternal obesity increases the risk of developing perinatal complications and delivery by cesarean section and has long-term implications in the development of metabolic diseases. Physical exercise during pregnancy contributes to overall improved health post-partum. It is also interesting to highlight the relevance of sleep problems during pregnancy, which influence adequate growth and fetal development. Taking into account these considerations, we conclude that nutrition and metabolic factors during early life play a key role of health promotion and public health nutrition programs worldwide to improve the health of the offspring and the health costs of hospitalization.

scholarly journals A Narrative Review of Motor Competence in Children and Adolescents: What We Know and What We Need to Find Out

2020 ◽  
Vol 18 (1) ◽  
pp. 18
Author(s):  
Luís Lopes ◽  
Rute Santos ◽  
Manuel Coelho-e-Silva ◽  
Catherine Draper ◽  
Jorge Mota ◽  
...  
Keyword(s):  
Physical Activity ◽  
Children And Adolescents ◽  
Current Knowledge ◽  
Public Health Problem ◽  
Positive Association ◽  
Premature Mortality ◽  
Narrative Review ◽  
Global Public Health ◽  
Motor Competence ◽  
Physically Active

Lack of physical activity is a global public health problem causing not only morbidity and premature mortality, but it is also a major economic burden worldwide. One of the cornerstones of a physically active lifestyle is Motor Competence (MC). MC is a complex biocultural attribute and therefore, its study requires a multi-sectoral, multi-, inter- and transdisciplinary approach. MC is a growing area of research, especially in children and adolescents due to its positive association with a plethora of health and developmental outcomes. Many questions, however, remain to be answered in this field of research, with regard to: (i) Health and Developmental-related Associations of MC; (ii) Assessment of MC; (iii) Prevalence and Trends of MC; (iv) Correlates and Determinants of MC; (v) MC Interventions, and (vi) Translating MC Research into Practice and Policy. This paper presents a narrative review of the literature, summarizing current knowledge, identifying key research gaps and presenting questions for future investigation on MC in children and adolescents. This is a collaborative effort from the International Motor Competence Network (IMCNetwork) a network of academics and researchers aiming to promote international collaborative research and knowledge translation in the expansive field of MC. The knowledge and deliverables generated by addressing and answering the aforementioned research questions on MC presented in this review have the potential to shape the ways in which researchers and practitioners promote MC and physical activity in children and adolescents across the world.

scholarly journals (Neuro) Peptides, Physical Activity, and Cognition

2020 ◽  
Vol 9 (8) ◽  
pp. 2592 ◽  
Author(s):  
Juho Autio ◽  
Ville Stenbäck ◽  
Dominique D. Gagnon ◽  
Juhani Leppäluoto ◽  
Karl-Heinz Herzig
Keyword(s):  
Physical Activity ◽  
Amino Acids ◽  
Current Knowledge ◽  
Elevated Serum ◽  
Brain Health ◽  
Insulin Growth Factor ◽  
Beneficial Effects ◽  
Positive Effects ◽  
The Central Nervous System

Regular physical activity (PA) improves cognitive functions, prevents brain atrophy, and delays the onset of cognitive decline, dementia, and Alzheimer’s disease. Presently, there are no specific recommendations for PA producing positive effects on brain health and little is known on its mediators. PA affects production and release of several peptides secreted from peripheral and central tissues, targeting receptors located in the central nervous system (CNS). This review will provide a summary of the current knowledge on the association between PA and cognition with a focus on the role of (neuro)peptides. For the review we define peptides as molecules with less than 100 amino acids and exclude myokines. Tachykinins, somatostatin, and opioid peptides were excluded from this review since they were not affected by PA. There is evidence suggesting that PA increases peripheral insulin growth factor 1 (IGF-1) levels and elevated serum IGF-1 levels are associated with improved cognitive performance. It is therefore likely that IGF-1 plays a role in PA induced improvement of cognition. Other neuropeptides such as neuropeptide Y (NPY), ghrelin, galanin, and vasoactive intestinal peptide (VIP) could mediate the beneficial effects of PA on cognition, but the current literature regarding these (neuro)peptides is limited.

Managing Mobility

2012 ◽  
Author(s):  
Nicky Hayes ◽  
Julie Whitney
Keyword(s):  
Physical Activity ◽  
Sports Medicine ◽  
Heart Association ◽  
Well Being ◽  
Good Health ◽  
Activity Levels ◽  
Physically Active ◽  
Mortality And Morbidity ◽  
Beneficial Effects ◽  
Develop Type

This chapter addresses the fundamental nursing role in the management of mobility. Every nurse should possess the knowledge and skills to assess mobility needs, to select and implement evidence-based strategies to maintain mobility or assist mobility, and to review the effectiveness of these to inform any necessary changes in care. Mobility is the ability to move around independently. The most readily recognizable component of mobility is locomotion—the ability to walk. It includes transition from one position to another, which is necessary to allow walking to be incorporated into functional activities. Examples of transitions are moving from sitting to standing and from standing to lying down. Virtually all bodily systems are required for safe and effective mobility. Maintaining higher levels of physical activity has been associated with reduced mortality and morbidity from many common diseases (Gregg et al., 2003). People with higher levels of physical activity are less likely to suffer or die from cardiovascular disease (Kesaniemi et al., 2001), have reduced risk of all types of stroke (Wendel-Vos et al., 2004a; 2004b), gain less weight, are less likely to develop type 2 diabetes, breast or colon cancer, osteoarthritis, osteoporosis, falls, and depression (Kesaniemi et al., 2001; Thune and Furberg, 2001). Beneficial effects on cognition have also been documented, the most physically active having 20% lower risk of cognitive decline (Weuve et al., 2004; Yaffe et al., 2001). Maintaining good physical activity levels is associated with generalized well-being, and improved physical function, ability to perform activities of daily living, and walking distance. An active person is less likely to be disabled and is more likely to be independent. There is a lower incidence of depression in people who remain active, and physical activity is known to reduce the symptoms of clinical depression (Kesaniemi et al., 2001). For these reasons, it is important for nurses to promote the benefits of appropriate physical activity as part of their health promotion role. The American College of Sports Medicine and the American Heart Association recommends levels of physical activity required to maintain good health (Box 23.1).

Pre-eminence of Moderate to Robust Physical Activity in Battling COVID-19: A Narrative Review

2020 ◽  
Vol 11 (SPL1) ◽  
pp. 934-937
Author(s):  
Tasneem M. Lakkadsha ◽  
Kiran Kumar ◽  
Waqar M. Naqvi ◽  
Pratik Phansopkar
Keyword(s):  
Physical Activity ◽  
Mass Media ◽  
Physical Inactivity ◽  
Narrative Review ◽  
The Other ◽  
Physically Active ◽  
Corona Virus ◽  
Media Platform ◽  
Being There ◽  
History Books

In January 2020, we met with COVID-19 (aka SARS-Co-V-2 and/or Corona virus) on our news channels all the way from china. Little did we know that it would shake up our lives in such a manner that we had heard only in a movie or read in history books. Currently we are all in some sort of lockdown, be it in hospital/home or in our minds. Being there, most of us are facing certain kind of misery, be it emotional, mental, physical or social. To be expansive the most common stresses that have been addressed by people on mass media platform are feeling of depression and isolation caused by being away from family and friends, some are complaining of losing their enthusiasm, some of gaining weight, some of losing it and many more. Going through a pandemic is also helping people in some or the other way, one of which is being concerned about their health and habits to keep themselves fit and away from serious comorbidities which can stem out from physical inactivity and heightened stress levels. There are many ways to stay fit at home without any complex gym equipment, but far less is known about it. Thus, an understanding of methods through which one can become physically active with least complexity, easy availability, and appropriate utilization is need of the hour.

scholarly journals Sensory Profile of Adults with Reduced Food Intake and the Potential Roles of Nutrition and Physical Activity Interventions

2019 ◽  
Vol 10 (6) ◽  
pp. 1120-1125 ◽  
Author(s):  
Marie-Eve Mathieu ◽  
Ryan E R Reid ◽  
Neil A King
Keyword(s):  
Physical Activity ◽  
Food Intake ◽  
Physical Activity Intervention ◽  
Sensory Profile ◽  
Sensory Response ◽  
Older Individuals ◽  
Beneficial Effects ◽  
Physical Activity Interventions ◽  
Nutrition And Physical Activity ◽  
Sensory Training

ABSTRACT The sensory profile, referring to sight, smell, taste, hearing, and touch, plays an essential role in optimizing the habitual intake of energy and macronutrients. However, specific populations, such as older adults, are known to have impaired energy intake. In this paper, the relevance of sensory impairments in this older population is described, and the extent to which nutritional and physical activity interventions can modulate these sensory responses when food intake is insufficient is explored. With aging, all senses deteriorate, and in most cases, such deteriorations diminish the nutritional response. The only exception is sight, for which both positive and negative impacts on nutritional response have been reported. From a prevention perspective, nutritional interventions have been understudied, and to date, only hearing is known to be positively affected by a good nutritional profile. In comparison, physical activity has been more frequently studied in this context, and is linked to an improved preservation of 4 senses. Regarding treatment, very few studies have directly targeted sensory training, and the focus of research has tended to be on nutrition and physical activity intervention. Sensory training, and nutritional and physical activity treatments all have beneficial effects on the senses. In the future, researchers should focus on exploring gaps in the literature specifically concerning prevention, treatment, and sensory response to understand how to improve the efficacy of current approaches. In order to maintain sensory acuity and recover from sensory impairment, the current state of knowledge supports the importance of improving nutritional habits as well as physical activity early on in life. A combined approach, linking a detailed lifestyle profile with the assessment of numerous senses and one or more interventional approaches (nutrition, physical activity, sensory training, etc.), would be required to identify effective strategies to improve the nutritional state of older individuals.

scholarly journals Physical Exercise and Cardiac Repair: The Potential Role of Nitric Oxide in Boosting Stem Cell Regenerative Biology

Antioxidants ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1002
Author(s):  
Fabiola Marino ◽  
Mariangela Scalise ◽  
Eleonora Cianflone ◽  
Luca Salerno ◽  
Donato Cappetta ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Stem Cell ◽  
Physical Exercise ◽  
Cell Biology ◽  
Molecular Mechanisms ◽  
Heart Function ◽  
Stem Cell Biology ◽  
Myocardial Repair ◽  
Beneficial Effects

Over the years strong evidence has been accumulated showing that aerobic physical exercise exerts beneficial effects on the prevention and reduction of cardiovascular risk. Exercise in healthy subjects fosters physiological remodeling of the adult heart. Concurrently, physical training can significantly slow-down or even reverse the maladaptive pathologic cardiac remodeling in cardiac diseases, improving heart function. The underlying cellular and molecular mechanisms of the beneficial effects of physical exercise on the heart are still a subject of intensive study. Aerobic activity increases cardiovascular nitric oxide (NO) released mainly through nitric oxidase synthase 3 activity, promoting endothelium-dependent vasodilation, reducing vascular resistance, and lowering blood pressure. On the reverse, an imbalance between increasing free radical production and decreased NO generation characterizes pathologic remodeling, which has been termed the “nitroso-redox imbalance”. Besides these classical evidence on the role of NO in cardiac physiology and pathology, accumulating data show that NO regulate different aspects of stem cell biology, including survival, proliferation, migration, differentiation, and secretion of pro-regenerative factors. Concurrently, it has been shown that physical exercise generates physiological remodeling while antagonizes pathologic remodeling also by fostering cardiac regeneration, including new cardiomyocyte formation. This review is therefore focused on the possible link between physical exercise, NO, and stem cell biology in the cardiac regenerative/reparative response to physiological or pathological load. Cellular and molecular mechanisms that generate an exercise-induced cardioprotective phenotype are discussed in regards with myocardial repair and regeneration. Aerobic training can benefit cells implicated in cardiovascular homeostasis and response to damage by NO-mediated pathways that protect stem cells in the hostile environment, enhance their activation and differentiation and, in turn, translate to more efficient myocardial tissue regeneration. Moreover, stem cell preconditioning by and/or local potentiation of NO signaling can be envisioned as promising approaches to improve the post-transplantation stem cell survival and the efficacy of cardiac stem cell therapy.

scholarly journals Impact of Kinanthropometric Differences According to Non-Professional Sports Activity Practiced

2021 ◽  
Vol 11 (11) ◽  
pp. 5063
Author(s):  
Daniel J. Navas Harrison ◽  
Ana María Pérez Pico ◽  
Raquel Mayordomo
Keyword(s):  
Physical Activity ◽  
Body Composition ◽  
Professional Sports ◽  
Whole Body ◽  
Lower Body ◽  
Basketball Players ◽  
Sports Activity ◽  
Sedentary Population ◽  
Activity Performance ◽  
Amateur Athlete

Kinanthropometry allows us to analyze variations in physical dimensions and body composition. This study’s objective was to evaluate the kinanthropometric differences based on physical activity performance, depending on whether the lower body or the whole body is more or less potent and the differences with a sedentary population. We analyzed 131 individuals (74 men and 57 women), with an average age of 22.68 ± 2.98 years. We differentiated three populations: sedentary (n = 63), runners (n = 20), and basketball players (n = 48). Measurements and indices were obtained following the international protocol of the International Society for the Advancement of Kinanthropometry (ISAK). The results show differences between the populations regarding weight, height, wingspan, and certain perimeters, diameters, and morphotypes depending on the predominant training type and the sedentary population. These anthropometric measurements will allow the amateur athlete to compare between seasons or other moments of training, pay attention to their evolution, and assess the possibility of changes in training.

Relation between cognitive disorders and type of physical activity: Results of the FréLE cohort

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
C Dupré ◽  
N Barth ◽  
A El Moutawakkil ◽  
F Béland ◽  
F Roche ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cognitive Decline ◽  
Proportional Hazards ◽  
Cognitive Disorders ◽  
The Elderly ◽  
Cognitive Status ◽  
Global Test ◽  
Professional Activities ◽  
Beneficial Effects ◽  
The Impact

Abstract Background Few previous cohorts have studied the different type of physical activities and the degree of cognitive decline. The objective of this work was to analyze the leisure, domestic and professional activities with mild and moderate cognitive disorders in older people living in community. Methods The study used data from the longitudinal and observational study, FrèLE (FRagility: Longitudinal Study of Expressions). The collected data included: socio-demographic variables, lifestyle, and health status (frailty, comorbidities, cognitive status, depression). Cognitive decline was assessed by using: MMSE (Mini-Mental State Examination) and MoCA (Montreal Cognitive Assessment). MoCA was used with two cut-offs (26 and 17) so as to define mild and moderate cognitive disorders Physical activity was assessed by the PASE (Physical Activity Scale for the Elderly), structured in three sections: leisure, domestic and professional activities. Spline and proportional hazards regression models (Cox) were used to estimate the risk of cognitive disorders. Results At baseline, 1623 participants were included and the prevalence of cognitive disorders was 6.9% (MMSE) and 7.2% (MoCA), mild cognitive disorders was 71.3%. The mean age was 77 years, and 52% of the participants were women. After a 2 years long follow-up, we found 6.9% (MMSE) and 6% (MoCA) cognitive disorders on participants. Analyses showed that domestic activities were associated to cognitive decline (HR = 0.52 [0.28-0.94] for MMSE and HR = 0.48 [0.28-0.80] for MoCA). No association were found with leisure and professional activities, and no spline were significant with mild cognitive disorders. Conclusions Analysis showed a relationship between cognitive disorders and type of physical activity, thanks to the use of specific questionnaire of elderly and two global test of cognition. These findings will contribute to the debate on the beneficial effects of physical activity on cognition. Key messages This work allowed to compare two test of cognition and their link with physical activity. It contributes to the debate on the beneficial effects of physical activity on cognition. The work allowed us to see the effect of the different types of physical activity and the impact of the statistical method on the results.

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