scholarly journals Omega-3FAs Can Inhibit the Inflammation and Insulin Resistance of Adipose Tissue Caused by HHcy Induced Lipids Profile Changing in Mice

2021 ◽  
Vol 12 ◽  
Author(s):  
Jing Li ◽  
Heng Zhang ◽  
Yongqiang Dong ◽  
Xian Wang ◽  
Guang Wang
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Nlrp3 Inflammasome ◽  
Receptor Protein ◽  
Inflammasome Activation ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Lipids Profile

The adipose Nod-like receptor protein 3 (NLRP3) inflammasome initiates insulin resistance; however, the mechanism of inflammasome activation in adipose tissue remains elusive. In this study, homocysteine (Hcy) was found to participate in insulin resistance via a NLRP3 inflammasome-related process. Hcy-induced activation of NLRP3 inflammasomes were observed in adipose tissue during the generation of insulin resistance in vivo. This animal model suggests that diets high in omega-3 fatty acids alter serum and adipose lipid profiles, and in this way, omega-3 fatty acids may reduce adipose tissue inflammation and attenuate insulin resistance.

scholarly journals Ultralong TE In Vivo 1 H MR Spectroscopy of Omega‐3 Fatty Acids in Subcutaneous Adipose Tissue at 7 T

2018 ◽  
Vol 50 (1) ◽  
pp. 71-82 ◽  
Author(s):  
Martin Gajdošík ◽  
Lukas Hingerl ◽  
Antonín Škoch ◽  
Angelika Freudenthaler ◽  
Patrik Krumpolec ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Adipose Tissue ◽  
Mr Spectroscopy ◽  
Subcutaneous Adipose Tissue ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Subcutaneous Adipose

scholarly journals Omega-3 Fatty Acids Prevent Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome Activation

Immunity ◽  
2013 ◽  
Vol 38 (6) ◽  
pp. 1154-1163 ◽  
Author(s):  
Yiqing Yan ◽  
Wei Jiang ◽  
Thibaud Spinetti ◽  
Aubry Tardivel ◽  
Rosa Castillo ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Nlrp3 Inflammasome ◽  
Metabolic Disorder ◽  
Inflammasome Activation ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Nlrp3 Inflammasome Activation

scholarly journals Omega-3 Fatty Acids Reduce Adipose Tissue Macrophages in Human Subjects With Insulin Resistance

Diabetes ◽  
2013 ◽  
Vol 62 (5) ◽  
pp. 1709-1717 ◽  
Author(s):  
M. Spencer ◽  
B. S. Finlin ◽  
R. Unal ◽  
B. Zhu ◽  
A. J. Morris ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Human Subjects ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
Adipose Tissue Macrophages

scholarly journals The Impact of OMEGA-3 Fatty Acids Supplementation on Insulin Resistance and Content of Adipocytokines and Biologically Active Lipids in Adipose Tissue of High-Fat Diet Fed Rats

Nutrients ◽  
2019 ◽  
Vol 11 (4) ◽  
pp. 835 ◽  
Author(s):  
Chacińska ◽  
Zabielski ◽  
Książek ◽  
Szałaj ◽  
Jarząbek ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Fish Oil ◽  
High Fat Diet ◽  
Biologically Active ◽  
Omega 3 Fatty Acids ◽  
Omega 3 ◽  
High Fat ◽  
Fish Oil Supplementation

It has been established that OMEGA-3 polyunsaturated fatty acids (PUFAs) may improve lipid and glucose homeostasis and prevent the “low-grade” state of inflammation in animals. Little is known about the effect of PUFAs on adipocytokines expression and biologically active lipids accumulation under the influence of high-fat diet-induced obesity. The aim of the study was to examine the effect of fish oil supplementation on adipocytokines expression and ceramide (Cer) and diacylglycerols (DAG) content in visceral and subcutaneous adipose tissue of high-fat fed animals. The experiments were carried out on Wistar rats divided into three groups: standard diet–control (SD), high-fat diet (HFD), and high-fat diet + fish oil (HFD+FO). The fasting plasma glucose and insulin concentrations were examined. Expression of carnitine palmitoyltransferase 1 (CPT1) protein was determined using the Western blot method. Plasma adipocytokines concentration was measured using ELISA kits and mRNA expression was determined by qRT-PCR reaction. Cer, DAG, and acyl-carnitine (A-CAR) content was analyzed by UHPLC/MS/MS. The fish oil supplementation significantly decreased plasma insulin concentration and Homeostatic Model Assesment for Insulin Resistance (HOMA-IR) index and reduced content of adipose tissue biologically active lipids in comparison with HFD-fed subjects. The expression of CPT1 protein in HFD+FO in both adipose tissues was elevated, whereas the content of A-CAR was lower in both HFD groups. There was an increase of adiponectin concentration and expression in HFD+FO as compared to HFD group. OMEGA-3 fatty acids supplementation improved insulin sensitivity and decreased content of Cer and DAG in both fat depots. Our results also demonstrate that PUFAs may prevent the development of insulin resistance in response to high-fat feeding and may regulate the expression and secretion of adipocytokines in this animal model.

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