scholarly journals Electroacupuncture Regularizes Gastric Contraction and Reduces Apoptosis of Interstitial Cells of Cajal in Diabetic Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Hongcai Wang ◽  
Kaile Zhao ◽  
Ning Shi ◽  
Qiong Niu ◽  
Chengxia Liu ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Gastric Motility ◽  
Interstitial Cells Of Cajal ◽  
Gastrointestinal Symptoms ◽  
Interstitial Cells ◽  
Diabetic Rats ◽  
The Body ◽  
Gastric Contraction ◽  
Cells Of Cajal

Background/AimsGastric dysmotility is a frequent complication among patients with diabetes mellitus. Electroacupuncture (EA) has been empirically used to relieve gastrointestinal symptoms. The aims of this study were to investigate the effects of EA on gastric contraction and the mechanisms of interstitial cells of Cajal (ICC) involved.Materials and MethodsMale Sprague–Dawley rats were randomized into the normal control, diabetes (DM), diabetic and sham EA (DM + SEA), diabetic and low-frequency EA (DM + LEA), and diabetic and high-frequency EA (DM + HEA) groups. Diabetic models were established and then treated with EA for 8 weeks. Body weight and blood glucose were recorded every 2 weeks. The spontaneous contractions of distal gastric strips were analyzed. Immunostaining and RT-PCR were used to test the apoptotic ICC, IGF-1/IGF-1R, and Nrf2/HO-1 pathways.ResultsThe body weight in the DM + LEA and DM + HEA groups were increased compared with that of the DM group, though there was no effect on the blood glucose. The gastric contractions were obviously disordered in the DM group, but EA could regularize the contractions. The number of apoptotic ICC was dramatically increased in the DM group, but reduced with EA treatment. Meanwhile, the IGF-1/IGF-1R pathway was verified to be significantly altered in diabetic rats. The Nrf2/HO-1 pathway was not significantly increased in the DM group. EA with different frequencies efficiently improved the expression of IGF-1/IGF-1R signaling and activated the Nrf2/HO-1 pathway.ConclusionEA could improve gastric motility dysfunction and attenuate ICC apoptosis possibly through the regulation of IGF-1/IGF-1R and Nrf2/HO-1 pathways. EA may be a potential therapeutic method for diabetic gastric motility dysfunction.

Hepatoproective Nature of Aerial parts of Caesalpinia pulcherrima in STZ Induced Diabetic Rat Model

2021 ◽  
pp. 3716-3720
Author(s):  
Pooja Pooja ◽  
Mazumder Avijit ◽  
Soumya Das
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Standard Drug ◽  
Liver Marker Enzymes

Diabetes is a chronic disease which characterized by hyperglycemia (elevated or abnormally high blood sugar levels) and other metabolic disturbances, including metabolism of lipids and haemostasis. Caesalpinia pulcherrima has previously showed strong anti-diabetic and hepatoprotective potential. The present research work was to investigate the anti-diabetic activity and hepatoprotective activity Caesalpinia pulcherrima in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 45days oral treatment with methanol extract of plant (200 and 300mg/kg) of CPAE on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration methanolic extract of Caesalpinia pulcherrima of showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of Caesalpinia pulcherrima has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug metformin and hence might be of use in the management of diabetes.

Anti- and pro-oxidant effects of quercetin stabilized by microencapsulation on interstitial cells of Cajal, nitrergic neurons and M2-like macrophages in the jejunum of diabetic rats

2020 ◽  
Vol 77 ◽  
pp. 193-204 ◽  
Author(s):  
Flávia Cristina Vieira-Frez ◽  
Camila Caviquioli Sehaber-Sierakowski ◽  
Juliana Vanessa Colombo Martins Perles ◽  
Gleison Daion Piovezana Bossolani ◽  
Waldiceu Aparecido Verri ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Diabetic Rats ◽  
Cells Of Cajal

Roles of Stem Cell Factor on Loss of Interstitial Cells of Cajal in Bladder of Diabetic Rats

Urology ◽  
2011 ◽  
Vol 78 (6) ◽  
pp. 1443.e1-1443.e6 ◽  
Author(s):  
Wei Chen ◽  
Chonghe Jiang ◽  
Xiyu Jin ◽  
Wenhao Shen ◽  
Bo Song ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Factor ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Diabetic Rats ◽  
Cells Of Cajal

T1363 Effects of Blood Glucose and Insulin On Interstitial Cells of Cajal in Diabetic Mice Colon

2008 ◽  
Vol 134 (4) ◽  
pp. A-539
Author(s):  
Lin Lin ◽  
Yurong Tang ◽  
Liming Xu ◽  
Li Xueliang ◽  
Hongjie Zhang ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Diabetic Mice ◽  
Cells Of Cajal

scholarly journals Investigation of the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract and onion powder in diabetic rats

2021 ◽  
Author(s):  
Sara Masood ◽  
Attiq ur Rehman ◽  
Shahid Bashir ◽  
Mohamed El Shazly ◽  
Muhammad Imran ◽  
...  
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Diabetic Rats ◽  
The Body ◽  
Wheat Bread ◽  
Control Group ◽  
Onion Peel ◽  
Antioxidant Effects ◽  
Onion Peel Extract ◽  
Peel Extract

Abstract Aim Onion is one of the commonly cultivated and consumed vegetables rich in nutrients and phytochemicals. Various nutraceuticals are found in the outer fleshy layers and dry peel of onion which usually is treated as a common biowaste. Diabetes mellitus is a leading non communicable disease causing hyperglycemia and increased production of free radicals that potentially disrupts antioxidant enzymatic activity. Considering global consumption of wheat, the present study was designed to evaluate the anti-hyperglycemic and antioxidant effects of wheat bread supplemented with onion peel extract (OPE) or onion powder (OP) on diabetic rats. Methods In this study, ethanolic extract of onion peel and onion bulb were prepared separately. Male Sprague Dawley rats were divided into 6 groups (n = 7). Different regimens of supplemented wheat bread (OPE (1% and 3%) and OP (5% and 7%)) were given to diabetic rats for eight weeks, plain bread was used as the control. Blood glucose level, body weight and activities of SOD, CAT, GPx, GR, GSH and MDA in the liver and kidney tissues were evaluated. Statistical analysis was performed using SPSS Version (25) and Dunnett’s multiple comparison test. Results Bread supplemented with 1% and 3% onion peel extract and 7% onion powder significantly reduced blood glucose levels and MDA in the treated rats compared with the control group diabetic rats. Body weight of diabetic rats was reduced for control group, while onion supplemented diet improved the body weight of treated rats. Onion supplementation also brought significant improvement in antioxidant enzyme activities among the treated diabetic rats. Conclusion These findings suggested that onion supplementation is effective in lowering blood glucose and could potentially aid in protecting organs from oxidative stress.

scholarly journals Anti-diabetic Activity of Ethanolic Extract of Elaeocarpus serratus L. in Streptozotocin-Induced Diabetic Rats

2016 ◽  
Vol 8 (01) ◽  
Author(s):  
DH Geetha ◽  
Indhiramuthu Jayashree ◽  
M. Rajeswari
Keyword(s):  
Body Weight ◽  
Blood Glucose ◽  
Blood Glucose Level ◽  
Glucose Level ◽  
Ethanolic Extract ◽  
Diabetic Rats ◽  
The Body ◽  
Marker Enzymes ◽  
Metabolizing Enzymes ◽  
Liver Marker Enzymes

To investigate the anti-diabetic activity of Elaeocarpus serratus fruit in streptozotocin-induced (STZ) diabetic rats. The dose-dependent effects of 30days oral treatment with ethanol extracts of fruit (200 and 400 mg/kg) of E. serratus on body weight, blood glucose level, total protein, albumin, liver marker enzymes and carbohydrate metabolizing enzymes were evaluated in STZ-induced diabetic rats. Oral administration ethanolic extract of fruit of E. serratus showed significant restoration of the body weight and decrease in the blood glucose level, liver marker enzymes (ALT, AST ALP) and carbohydrate metabolizing enzymes were observed in diabetic rats. These results suggest that fruit extract of E. serratus has valuable anti-diabetic activity in STZ-induced diabetic rats which is comparable to the standard drug glibenclamide and hence might be of use in the management of diabetes.

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