scholarly journals Anise Hyssop Agastache foeniculum Increases Lifespan, Stress Resistance, and Metabolism by Affecting Free Radical Processes in Drosophila

2020 ◽  
Vol 11 ◽  
Author(s):  
Olha M. Strilbytska ◽  
Alina Zayachkivska ◽  
Alexander Koliada ◽  
Fabio Galeotti ◽  
Nicola Volpi ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Antioxidant Properties ◽  
Dietary Supplementation ◽  
Egg Laying ◽  
Independent Manner ◽  
Metabolic Traits ◽  
Elevated Protein ◽  
Markers Of Oxidative Stress ◽  
Leaf Powder

Anise hyssop, Agastache foeniculum, is a widely used medicinal herb with known antioxidant properties. We studied how dietary supplementation with dried A. foeniculum leaf powder affected physiological and metabolic traits as well as activities of antioxidant enzymes and markers of oxidative stress in Drosophila melanogaster. Dietary hyssop extended the lifespan in a sex and genotype independent manner over a broad range of concentrations up to 30 mg/ml. Dietary supplementation with the herb significantly increased fecundity, resistance to oxidative stress and starvation. Higher transcript levels of Drosophila insulin-like peptide (dilp2) and decreased dilp3 and dilp6 transcripts together with increased levels of glycogen and triacylglycerols support an alteration of insulin signaling by the plant extract. Increased enzymatic activities of superoxide dismutase and aconitase as well as elevated protein and low molecular mass thiols also supported an alteration of free radical process in flies treated with dietary A. foeniculum leaf powder. Thus, physiological and metabolic traits as well as free radical processed may be affected by active compounds detected in extracts of anise hyssop leaves and contribute to the increased lifespan and reproductive (egg-laying) activity observed.

scholarly journals Ethanol Extract of Maclura tricuspidata Fruit Protects SH-SY5Y Neuroblastoma Cells against H2O2-Induced Oxidative Damage via Inhibiting MAPK and NF-κB Signaling

2021 ◽  
Vol 22 (13) ◽  
pp. 6946
Author(s):  
Weishun Tian ◽  
Suyoung Heo ◽  
Dae-Woon Kim ◽  
In-Shik Kim ◽  
Dongchoon Ahn ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Oxidative Damage ◽  
Cell Damage ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Biologically Active ◽  
Mitogen Activated Protein Kinase ◽  
Protective Effects ◽  
Neuroprotective Effects

Free radical generation and oxidative stress push forward an immense influence on the pathogenesis of neurodegenerative diseases such as Alzheimer’s disease and Parkinson’s disease. Maclura tricuspidata fruit (MT) contains many biologically active substances, including compounds with antioxidant properties. The current study aimed to investigate the neuroprotective effects of MT fruit on hydrogen peroxide (H2O2)-induced neurotoxicity in SH-SY5Y cells. SH-SY5Y cells were pretreated with MT, and cell damage was induced by H2O2. First, the chemical composition and free radical scavenging properties of MT were analyzed. MT attenuated oxidative stress-induced damage in cells based on the assessment of cell viability. The H2O2-induced toxicity caused by ROS production and lactate dehydrogenase (LDH) release was ameliorated by MT pretreatment. MT also promoted an increase in the expression of genes encoding the antioxidant enzymes superoxide dismutase (SOD) and catalase (CAT). MT pretreatment was associated with an increase in the expression of neuronal genes downregulated by H2O2. Mechanistically, MT dramatically suppressed H2O2-induced Bcl-2 downregulation, Bax upregulation, apoptotic factor caspase-3 activation, Mitogen-activated protein kinase (MAPK) (JNK, ERK, and p38), and Nuclear factor-κB (NF-κB) activation, thereby preventing H2O2-induced neurotoxicity. These results indicate that MT has protective effects against H2O2-induced oxidative damage in SH-SY5Y cells and can be used to prevent and protect against neurodegeneration.

scholarly journals Inhibition of Digestive Enzymes, Antioxidant and Free Radical Scavenging Capacities of Stem Bark Extracts of Coula edulis Baill (Olacaceae)

2021 ◽  
Vol 10 (5) ◽  
pp. 1
Author(s):  
Eric Beyegue ◽  
Boris G. K. Azantsa ◽  
Angie M-A Mbong ◽  
Julius E. Oben
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Ethanolic Extract ◽  
Stem Bark ◽  
Alpha Amylase ◽  
In Vitro Assays ◽  
Oh Radicals

Prolonged hyperglycemia enhances oxidative stress. Bioactive compounds extracted possess antioxidant, anti-free radical potentials or the ability to reduce blood sugar levels. The objective of this study was to evaluate the antioxidant properties of extracts of stem bark of Coula edulis Baill., their abilities to trap free radicals and glucose, as well as their ability to inhibit α-amylase and invertase activities. In vitro assays were used to test the trapping capacity of extracts on DPPH, ABTS, NO, and OH radicals; to evaluate the antioxidant capacity, the activity of glycosylation and the capacity of inhibition of the activities of α-amylase and invertase were conducted. Also, phenolic, flavonoid and alkaloid contents of extracts were determined. Results showed that extracts of the stem bark of C. edulis have anti-radical properties. The extracts chelate DPPH, hydroxyl (OH), nitrite oxide (NO), ABTS radicals, and even glucose. The IC50 values varied depending on the nature of the extraction solvent. Ethanolic extract has the highest polyphenolic content (289.12 ± 30.31 µg catechin equivalent/g), flavonoids (1.12 ± 0.09 µg quercetin equivalent/g) and alkaloids (5.54 ± 0.59 µg quinin equivalent/g). The extracts also reduce invertase and α-amylase activities. C. edulis extracts present strong antioxidant potentials and can be used as a source of natural antioxidants for the prevention of oxidative stress and hyperglycemia.

scholarly journals Role of thioldisulfid of system in mechanism of oxidative stress and distress at HIV of infection

2010 ◽  
Vol 56 (2) ◽  
pp. 290-298 ◽  
Author(s):  
V.V. Kostyushov ◽  
I.I. Bokal
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Biochemical Markers ◽  
Redox System ◽  
Therapeutic Application ◽  
Redox Transformations ◽  
Markers Of Oxidative Stress ◽  
General Protein

In the article general conformities to law and features of violation of the thioldisulfid an redox system of whey of blood are described for patients with the without a symptom transmitter of HIV and manifestly forms AIDS. The role of her components is grounded - general, protein and non protein -SH, -S-S- groups in the mechanism of forming of oxidative stress and distress at HIV of infection. The clinic and laboratory criterions of expressed of peroxides processes are specified on the indexes of violation of redox transformations of -SH, -S-S- groups, neutralization and utilization of MDA and stability of LPC in the whey of blood at HIV of infection. Found out intercommunication between expressed of violation of the studied indexes, oxidative stress and distress and features of clinical flow of HIV of infection, allowed authors to attribute this pathology to "free radical diseases". In this connection, indicated analytic it is suggested to use as additional biochemical markers of oxidative stress and distress, and also for the ground of setting of antioxidants and their combinations in complex prophylactic or therapeutic application at HIVof infection.

scholarly journals The Effect of Melatonin on Periodontitis

2021 ◽  
Vol 22 (5) ◽  
pp. 2390
Author(s):  
Barbora Konečná ◽  
Paulína Chobodová ◽  
Jakub Janko ◽  
Lenka Baňasová ◽  
Janka Bábíčková ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Chronic Conditions ◽  
Alveolar Bone ◽  
Bacterial Colonization ◽  
Antioxidant Properties ◽  
Human Study ◽  
Treatment Resistant ◽  
Study Results ◽  
Markers Of Oxidative Stress ◽  
And Oxidative Stress

Background: Periodontitis is a chronic disease with a complex etiology that includes bacterial colonization, excessive inflammation, and oxidative stress. The hormone melatonin has antioxidant properties and might contribute to alleviating chronic conditions by reducing oxidative stress. The aim of this study was to analyze the effect of exogenous melatonin on periodontitis in an animal model of the disease as well as in patients with periodontitis. Methods: In rats with ligature-induced periodontitis, melatonin was administered in drinking water for two weeks. In the human study, patients with treatment-resistant periodontitis were asked to rinse their mouths with a solution containing melatonin or placebo every evening for two weeks. Periodontal status as well as salivary markers of oxidative stress were assessed at the end of the study. Results: Neither radiography nor μCT revealed any significant effects of melatonin on alveolar bone loss. Gum recession was the only improved macroscopic measure in rats (p < 0.05). Analysis of salivary markers of oxidative stress revealed no effects of treatment in rats or humans despite clearly elevated melatonin concentrations in melatonin treated groups. Conclusion: Our results do not support the use of melatonin for the treatment of periodontitis. However, the negative outcome is limited by the short duration of the study and the chosen route of application as well as the dose of melatonin.

scholarly journals Discovering the Health Promoting Potential of Fermented Papaya Preparation—Its Future Perspectives for the Dietary Management of Oxidative Stress During Diabetes

Fermentation ◽  
2018 ◽  
Vol 4 (4) ◽  
pp. 83 ◽  
Author(s):  
Jhoti Somanah ◽  
Manish Putteeraj ◽  
Okezie Aruoma ◽  
Theeshan Bahorun
Keyword(s):  
Oxidative Stress ◽  
Free Radical ◽  
Stress Reduction ◽  
Senile Dementia ◽  
Antioxidant Properties ◽  
Radical Scavenging ◽  
Morphological Characteristics ◽  
Holistic Approach ◽  
Amino Acid Profile ◽  
Protective Effects

The simplistic morphological characteristics of Carica papaya fruit or “pawpaw” should not be the cause for underestimating its potential as a nutraceutical. The market for papaya has been expanding at a staggering rate, partly due to its applicability as a biofortified product, but also due to its phytochemical properties and traditional health benefits. Papaya or formulations of fermented papaya promotion (FPP) display effective free radical scavenging abilities thought to be influenced by its phenolic, carotenoid, flavonoid, or amino acid profile. The antioxidant properties of FPP have been extensively reported in literature to potently target a broad spectrum of free radical-induced diseases ranging from neurological impairments, such as senile dementia, to systemic diseases, to its interference at the cellular level and the support of normal biological ageing processes. FPP has thus been extensively investigated for its ability to exert cellular protective effects and reduce oxidative stress via the mitigation of genetic damage, reduction of lipid peroxidation, and enzymatic inactivation in specific diseases. The focus of this review is to appraise the potential of oxidative stress reduction strategies of FPP and discuss its holistic approach in disease prevention and management, with a particular focus on diabetes and cancer. However, with the current lack of information surrounding its mechanism of action, this review wishes to set the stage and aspire researchers to more profoundly investigate molecular pathways related to how FPP can unequivocally contribute to wellness in an aging population.

Elevated protein carbonyls as plasma markers of oxidative stress in acute pancreatitis

Pancreatology ◽  
2003 ◽  
Vol 3 (5) ◽  
pp. 375-382 ◽  
Author(s):  
Christine C. Winterbourn ◽  
Martin J.D. Bonham ◽  
Hendrikje Buss ◽  
Fikri M. Abu-Zidan ◽  
John A. Windsor
Keyword(s):  
Oxidative Stress ◽  
Acute Pancreatitis ◽  
Protein Carbonyls ◽  
Elevated Protein ◽  
Markers Of Oxidative Stress ◽  
Plasma Markers

scholarly journals A difficult patient at a cosmetologist appointment: early lip changes in women smokers: causes, and methods of correction

2020 ◽  
Vol 23 (1) ◽  
pp. 57-64
Author(s):  
M. A. Shirshakova ◽  
Elena A. Morozova
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Oxidative Dna Damage ◽  
Antioxidant Properties ◽  
Reactive Oxygen ◽  
Chronic Obstructive ◽  
Oxygen Species ◽  
Difficult Patient ◽  
Chronic Obstructive Pulmonary Diseases ◽  
Markers Of Oxidative Stress

A smokers lips are more likely to change because of exposure to reactive oxygen species that contain oxygen in large quantities in tobacco smoke. Oxidative stress is a crucial factor in the development of smoking-related diseases, such as oral cancer, lung cancer, and chronic obstructive pulmonary diseases. The damaging effect occurs because of the imbalance between the generation of reactive oxygen species and their detoxification. Markers of oxidative stress include parameters of lipid peroxidation, the activity of glutathione and antioxidant enzymes, and oxidative DNA damage. The destruction of hyaluronic acid (HA), the only drug used to correct lip changes, in smokers is accelerated by its participation in reactions with active oxygen forms, and not just by pathemization because of enzymatic cleavage by hyaluronidase. Mannitol has strong antioxidant properties, which makes it an ideal auxiliary substance in the composition of fillers based on HA. The role of reactive oxygen species in the aging process and their effects on both endogenous HA and HA-based drugs developed for esthetic use are discussed. A review of drugs, based on mannitol with hyaluronic fillers, is provided. The inclusion of mannitol in hyaluronic fillers is an effective and safe way to improve both short-term and long-term esthetic effects of the HA injection.

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