scholarly journals Pathogenesis of Molar Hypomineralisation: Aged Albumin Demarcates Chalky Regions of Hypomineralised Enamel

2020 ◽  
Vol 11 ◽  
Author(s):  
Vidal A. Perez ◽  
Jonathan E. Mangum ◽  
Michael J. Hubbard
Keyword(s):  
Molar Hypomineralisation

scholarly journals Pathogenesis of Molar Hypomineralisation: Hypomineralised 6-Year Molars Contain Traces of Fetal Serum Albumin

2020 ◽  
Vol 11 ◽  
Author(s):  
Rebecca Williams ◽  
Vidal A. Perez ◽  
Jonathan E. Mangum ◽  
Michael J. Hubbard
Keyword(s):  
Serum Albumin ◽  
Fetal Serum ◽  
Molar Hypomineralisation

Second primary molar hypomineralisation and drugs used during pregnancy and infancy. A systematic review

2019 ◽  
Vol 24 (3) ◽  
pp. 1287-1297 ◽  
Author(s):  
Clara Serna Muñoz ◽  
Antonio J. Ortiz Ruiz ◽  
Amparo Pérez Silva ◽  
Luis Alberto Bravo-González ◽  
Ascensión Vicente
Keyword(s):  
Systematic Review ◽  
Second Primary ◽  
Primary Molar ◽  
Molar Hypomineralisation

Mineral content in teeth with Deciduous Molar Hypomineralisation (DMH)

2013 ◽  
Vol 41 (11) ◽  
pp. 974-978 ◽  
Author(s):  
M.E.C. Elfrink ◽  
J.M. ten Cate ◽  
L.J. van Ruijven ◽  
J.S.J. Veerkamp
Keyword(s):  
Mineral Content ◽  
Deciduous Molar ◽  
Molar Hypomineralisation

scholarly journals A Breakthrough in Understanding the Pathogenesis of Molar Hypomineralisation: The Mineralisation-Poisoning Model

2021 ◽  
Vol 12 ◽  
Author(s):  
Michael J. Hubbard ◽  
Jonathan E. Mangum ◽  
Vidal A. Perez ◽  
Rebecca Williams
Keyword(s):  
Global Health ◽  
Extracellular Fluid ◽  
Childhood Illness ◽  
Future Research ◽  
Medical Prevention ◽  
New Type ◽  
Research And Education ◽  
Education Network ◽  
First Time ◽  
Molar Hypomineralisation

Popularly known as “chalky teeth”, molar hypomineralisation (MH) affects over 1-in-5 children worldwide, triggering massive amounts of suffering from toothache and rapid decay. MH stems from childhood illness and so offers a medical-prevention avenue for improving oral and paediatric health. With a cross-sector translational research and education network (The D3 Group; thed3group.org) now highlighting this global health opportunity, aetiological understanding is urgently needed to enable better awareness, management and eventual prevention of MH. Causation and pathogenesis of “chalky enamel spots” (i.e., demarcated opacities, the defining pathology of MH) remain unclear despite 100 years of investigation. However, recent biochemical studies provided a pathomechanistic breakthrough by explaining several hallmarks of chalky opacities for the first time. This article outlines these findings in context of previous understanding and provides a working model for future investigations. The proposed pathomechanism, termed “mineralisation poisoning”, involves localised exposure of immature enamel to serum albumin. Albumin binds to enamel-mineral crystals and blocks their growth, leading to chalky opacities with distinct borders. Being centred on extracellular fluid rather than enamel-forming cells as held by dogma, this localising pathomechanism invokes a new type of connection with childhood illness. These advances open a novel direction for research into pathogenesis and causation of MH, and offer prospects for better clinical management. Future research will require wide-ranging inputs that ideally should be coordinated through a worldwide translational network. We hope this breakthrough will ultimately lead to medical prevention of MH, prompting global health benefits including major reductions in childhood tooth decay.

Is Maternal Use of Medicines during Pregnancy Associated with Deciduous Molar Hypomineralisation in the Offspring? A Prospective, Population-Based Study

Drug Safety ◽  
2013 ◽  
Vol 36 (8) ◽  
pp. 627-633 ◽  
Author(s):  
Marlies E. C. Elfrink ◽  
Henriette A. Moll ◽  
Jessica C. Kiefte-de Jong ◽  
Hanan El Marroun ◽  
Vincent W. V. Jaddoe ◽  
...  
Keyword(s):  
Population Based ◽  
Population Based Study ◽  
Deciduous Molar ◽  
Molar Hypomineralisation

scholarly journals Relationship between deciduous molar hypomineralisation and parameters of bone metabolism in preschool children

2020 ◽  
Vol 70 (4) ◽  
pp. 303-307
Author(s):  
Wieland Elger ◽  
Christina Illge ◽  
Wieland Kiess ◽  
Antje Körner ◽  
Jürgen Kratzsch ◽  
...  
Keyword(s):  
Preschool Children ◽  
Bone Metabolism ◽  
Deciduous Molar ◽  
Molar Hypomineralisation

Distribution and severity of molar hypomineralisation: trial of a new severity index

2013 ◽  
Vol 24 (2) ◽  
pp. 131-151 ◽  
Author(s):  
Kelly Oliver ◽  
Louise B. Messer ◽  
David J. Manton ◽  
Karen Kan ◽  
Fiona Ng ◽  
...  
Keyword(s):  
Severity Index ◽  
Molar Hypomineralisation

scholarly journals Management of a Hypomineralisation of the Enamel by Applying a Remineraliser Based on Zinc Hydroxyapatite (microRepair)

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
G. Solinas ◽  
V. Grabesu ◽  
M. Lattari ◽  
R. Strinna ◽  
N. Arnould ◽  
...  
Keyword(s):  
Case Report ◽  
Assessment Scale ◽  
Clinical Appearance ◽  
One Year ◽  
Observation Period ◽  
Molar Hypomineralisation ◽  
At Home

According to our experience, the treatment with remineralising mousse based on biomimetic nanohydroxyapatite has the advantage of being easily implemented by all patients as it is economical and absolutely noninvasive. The following case report reports the results obtained from the use of a mousse based on biomimetic nanohydroxyapatite for the treatment of incisor and molar hypomineralisation. This case report illustrates the case of a 4-year-old patient who was diagnosed with MIH and was subjected to remineralising treatments at home for six months, at alternating periods. Throughout the observation period, the painful perception of the lesions was detected through an assessment scale, and the clinical appearance was documented photographically. One year after the diagnosis, all the elements involved no longer showed any symptoms.

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