scholarly journals Palmitoyl Protein Thioesterase 1 Is Essential for Myogenic Autophagy of C2C12 Skeletal Myoblast

2020 ◽  
Vol 11 ◽  
Author(s):  
Hyeong Rok Yun ◽  
Yong Hwa Jo ◽  
Jieun Kim ◽  
Ngoc Ngo Yen Nguyen ◽  
Yoonhwa Shin ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Palmitoyl Protein Thioesterase

Anti-Mycobacterial Peroxides: A New Class of Agents for Development Against Tuberculosis

2020 ◽  
Vol 16 (3) ◽  
pp. 392-402
Author(s):  
Christiaan W. van der Westhuyzen ◽  
Richard K. Haynes ◽  
Jenny-Lee Panayides ◽  
Ian Wiid ◽  
Christopher J. Parkinson
Keyword(s):  
Subsequent Development ◽  
Antitubercular Activity ◽  
Organic Peroxide ◽  
New Drugs ◽  
Skeletal Myoblast ◽  
Artemisinin Derivatives ◽  
Malaria Therapy ◽  
New Class ◽  
Alternative Approach

Background: With few exceptions, existing tuberculosis drugs were developed many years ago and resistance profiles have emerged. This has created a need for new drugs with discrete modes of action. There is evidence that tuberculosis (like other bacteria) is susceptible to oxidative pressure and this has yet to be properly utilised as a therapeutic approach in a manner similar to that which has proven highly successful in malaria therapy. Objective: To develop an alternative approach to the incorporation of bacterial siderophores that results in the creation of antitubercular peroxidic leads for subsequent development as novel agents against tuberculosis. Methods: Eight novel peroxides were prepared and the antitubercular activity (H37Rv) was compared to existing artemisinin derivatives in vitro. The potential for toxicity was evaluated against the L6 rat skeletal myoblast and HeLa cervical cancer lines in vitro. Results: The addition of a pyrimidinyl residue to an artemisinin or, preferably, a tetraoxane peroxidic structure results in antitubercular activity in vitro. The same effect is not observed in the absence of the pyrimidine or with other heteroaromatic substituents. Conclusion: The incorporation of a pyrimidinyl residue adjacent to the peroxidic function in an organic peroxide results in anti-tubercular activity in an otherwise inactive peroxidic compound. This will be a useful approach for creating oxidative drugs to target tuberculosis.

Autologous skeletal myoblast transplantation attenuates left ventricular dilatation without improving cardiac function

2003 ◽  
Vol 9 (5) ◽  
pp. S1
Author(s):  
Patrick I. McConnell ◽  
Louis Astra ◽  
E.William Schneeberger ◽  
Doug Jacoby ◽  
Jonathan Dinsmore ◽  
...  
Keyword(s):  
Cardiac Function ◽  
Left Ventricular ◽  
Ventricular Dilatation ◽  
Skeletal Myoblast ◽  
Left Ventricular Dilatation ◽  
Myoblast Transplantation

scholarly journals Long-term outcomes of autologous skeletal myoblast cell-sheet transplantation for end-stage ischemic cardiomyopathy

2021 ◽  
Author(s):  
Satoshi Kainuma ◽  
Shigeru Miyagawa ◽  
Koichi Toda ◽  
Yasushi Yoshikawa ◽  
Hiroki Hata ◽  
...  
Keyword(s):  
Ischemic Cardiomyopathy ◽  
Cell Sheet ◽  
Long Term Outcomes ◽  
Skeletal Myoblast ◽  
Myoblast Cell ◽  
End Stage

scholarly journals Mutations in palmitoyl-protein thioesterase 1 alter exocytosis and endocytosis at synapses inDrosophilalarvae

Fly ◽  
2013 ◽  
Vol 7 (4) ◽  
pp. 267-279 ◽  
Author(s):  
Elizabeth Aby ◽  
Katherine Gumps ◽  
Amalia Roth ◽  
Stacey Sigmon ◽  
Sarah E Jenkins ◽  
...  
Keyword(s):  
Palmitoyl Protein Thioesterase

Construction of Skeletal Myoblast-Based Polyurethane Scaffolds for Myocardial Repair

2007 ◽  
Vol 31 (6) ◽  
pp. 425-433 ◽  
Author(s):  
Matthias Siepe ◽  
Marie-Noelle Giraud ◽  
Elisabeth Liljensten ◽  
Urs Nydegger ◽  
Philippe Menasche ◽  
...  
Keyword(s):  
Myocardial Repair ◽  
Skeletal Myoblast

scholarly journals Intramyocardial microdepot injection increases the efficacy of skeletal myoblast transplantation

2005 ◽  
Vol 27 (6) ◽  
pp. 1017-1021 ◽  
Author(s):  
H OTT ◽  
R KROESS ◽  
N BONAROS ◽  
R MARKSTEINER ◽  
E MARGREITER ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Myoblast Transplantation

Developmental expression of palmitoyl protein thioesterase in normal mice

1999 ◽  
Vol 118 (1-2) ◽  
pp. 1-11 ◽  
Author(s):  
Juha Isosomppi ◽  
Outi Heinonen ◽  
Jukka O Hiltunen ◽  
Nicholas D.E Greene ◽  
Jouni Vesa ◽  
...  
Keyword(s):  
Developmental Expression ◽  
Palmitoyl Protein Thioesterase

scholarly journals SLIMMER (FHL1B/KyoT3) Interacts with the Proapoptotic Protein Siva-1 (CD27BP) and Delays Skeletal Myoblast Apoptosis

2009 ◽  
Vol 284 (39) ◽  
pp. 26964-26977 ◽  
Author(s):  
Denny L. Cottle ◽  
Meagan J. McGrath ◽  
Brendan R. Wilding ◽  
Belinda S. Cowling ◽  
Jordan M. Kane ◽  
...  
Keyword(s):  
Skeletal Myoblast ◽  
Proapoptotic Protein
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