scholarly journals Hydrogen Sulfide Alleviates Skeletal Muscle Fibrosis via Attenuating Inflammation and Oxidative Stress

2020 ◽  
Vol 11 ◽  
Author(s):  
Linlin Zhao ◽  
Xiaoguang Liu ◽  
Jing Zhang ◽  
Gaoyang Dong ◽  
Weihua Xiao ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Hydrogen Sulfide ◽  
Muscle Fibrosis ◽  
Skeletal Muscle Fibrosis ◽  
And Oxidative Stress

Abstract 13: Central Sympathoinhibition Abrogates Skeletal Muscle Fibrosis, Oxidative Stress and Autonomic Dysregulation in a Mouse Model of Muscular Dystrophy

Hypertension ◽  
2013 ◽  
Vol 62 (suppl_1) ◽  
Author(s):  
Rasna Sabharwal ◽  
Mark W Chapleau
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Locomotor Activity ◽  
Muscular Dystrophy ◽  
Sympathetic Activity ◽  
Muscle Pathology ◽  
Autonomic Dysregulation ◽  
Muscle Fibrosis ◽  
Skeletal Muscle Fibrosis ◽  
The Brain

Sarcoglycan mutations cause muscular dystrophy in humans. We recently demonstrated that sarcoglycan delta deficient (Sgcd-/-) mice with muscular dystrophy exhibit autonomic dysregulation [Hypertension 2010]. We hypothesized that excessive sympathetic activity contributes to skeletal muscle pathology, decreased locomotor activity and autonomic dysregulation in young (10-12 wks) Sgcd-/- mice. The centrally-acting sympathoinhibitory drug rilmenidine (RIL) was infused into the brain of control C57BL6 and Sgcd-/- mice by osmotic pump for 7-9 wks beginning at 3 wks of age (42 ng/g/hr, ICV). Separate groups of mice were infused with saline vehicle (VEH). Blood pressure (BP), heart rate (HR) and locomotor activity were measured by telemetry. Cardiac (HR responses to propranolol) and vasomotor (BP response to ganglionic blockade) sympathetic tone were increased in VEH-treated Sgcd-/- mice, and normalized by RIL (Table). The RIL-induced sympathoinhibition in Sgcd-/- mice was accompanied by increases in baroreflex sensitivity (BRS, sequence technique), cardiovagal tone (HR response to atropine) and activity, with no change in BP (Table). RIL also decreased oxidative stress (superoxide) by 56% and fibrosis in Sgcd-/- skeletal muscle. RIL did not affect measured variables in control mice (Table). In summary, RIL-induced sympathoinhibition decreased skeletal muscle pathology, increased locomotor activity and improved autonomic regulation in young Sgcd-/- mice. The results implicate increased sympathetic activity in the pathogenesis of muscular dystrophy, and suggest that targeting the brain to inhibit sympathetic activity may provide a novel therapeutic approach.

scholarly journals Astaxanthin supplementation attenuates immobilization-induced skeletal muscle fibrosis via suppression of oxidative stress

2016 ◽  
Vol 67 (5) ◽  
pp. 603-611 ◽  
Author(s):  
Toshiyuki Maezawa ◽  
Masayuki Tanaka ◽  
Miho Kanazashi ◽  
Noriaki Maeshige ◽  
Hiroyo Kondo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Muscle Fibrosis ◽  
Skeletal Muscle Fibrosis

ACS67, a Hydrogen Sulfide–Releasing Derivative of Latanoprost Acid, Attenuates Retinal Ischemia and Oxidative Stress to RGC-5 Cells in Culture

2010 ◽  
Vol 51 (1) ◽  
pp. 284 ◽  
Author(s):  
Neville N. Osborne ◽  
Dan Ji ◽  
Aman S. Abdul Majid ◽  
Rebecca J. Fawcett ◽  
Anna Sparatore ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Hydrogen Sulfide ◽  
Retinal Ischemia ◽  
Cells In Culture ◽  
And Oxidative Stress

NaHS inhibits NF-κB signal against inflammation and oxidative stress in post-infectious irritable bowel syndrome

RSC Advances ◽  
2016 ◽  
Vol 6 (69) ◽  
pp. 64208-64214 ◽  
Author(s):  
Shenglan Yang ◽  
Danfang Deng ◽  
Yingying Luo ◽  
Yanran Wu ◽  
Rui Zhu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Irritable Bowel Syndrome ◽  
Hydrogen Sulfide ◽  
Murine Model ◽  
Irritable Bowel ◽  
And Oxidative Stress ◽  
Post Infectious

In this study, the alleviating role of hydrogen sulfide (H2S) was investigated in a Post-Infectious Irritable Bowel Syndrome (PI-IBS) murine model and Caco-2 cells.

Time course of skeletal muscle loss and oxidative stress in rats with walker 256 solid tumor

2010 ◽  
Vol 42 (6) ◽  
pp. 950-958 ◽  
Author(s):  
Flávia A. Guarnier ◽  
Alessandra L. Cecchini ◽  
Andréia A. Suzukawa ◽  
Ana Leticia G.C. Maragno ◽  
Andréa N.C. Simão ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Solid Tumor ◽  
Time Course ◽  
Muscle Loss ◽  
Skeletal Muscle Loss ◽  
Walker 256 ◽  
And Oxidative Stress

scholarly journals Skeletal Muscle Regeneration and Oxidative Stress Are Altered in Chronic Kidney Disease

PLoS ONE ◽  
2016 ◽  
Vol 11 (8) ◽  
pp. e0159411 ◽  
Author(s):  
Keith G. Avin ◽  
Neal X. Chen ◽  
Jason M. Organ ◽  
Chad Zarse ◽  
Kalisha O’Neill ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Skeletal Muscle ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Muscle Regeneration ◽  
Skeletal Muscle Regeneration ◽  
And Oxidative Stress

Skeletal muscle fibrosis: the effect of stromal-derived factor-1α-loaded collagen scaffolds

2010 ◽  
Vol 5 (5) ◽  
pp. 737-747 ◽  
Author(s):  
Sander Grefte ◽  
Anne Marie Kuijpers-Jagtman ◽  
Ruurd Torensma ◽  
Johannes W Von den Hoff
Keyword(s):  
Skeletal Muscle ◽  
Collagen Scaffolds ◽  
Muscle Fibrosis ◽  
Skeletal Muscle Fibrosis
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