scholarly journals Membrane Physiology and Biophysics—What Remains to Be Done?

2020 ◽  
Vol 11 ◽  
Author(s):  
Christoph Fahlke
Keyword(s):  
Membrane Physiology

Cell and Membrane Physiology

1982 ◽  
Vol 44 (1) ◽  
pp. 295-295
Author(s):  
J Gergely
Keyword(s):  
Membrane Physiology

Quantitative ultrastructural analysis in cardiac membrane physiology

1978 ◽  
Vol 235 (5) ◽  
pp. C147-C158 ◽  
Author(s):  
E. Page
Keyword(s):  
Quantitative Analysis ◽  
Membrane Structure ◽  
Statistical Approach ◽  
Optical Diffraction ◽  
Intracellular Membrane ◽  
Quantitative Measurements ◽  
Yield Information ◽  
Morphometric Methods ◽  
Sampling Problems ◽  
Membrane Physiology

Quantitative measurements on electron micrographs of heart muscle can yield information useful for cellular physiologists and at present not obtainable in other ways. These methods are subject to preparative artifact, sampling problems, and problems inherent in the mathematical description of ultrastructure. Nevertheless they provide the best available data for membrane areas of the plasmalemma and its components, as well as for membrane areas of the sarcoplasmic reticulum and mitochondria. Morphometric methods can be used to study growth of membranes. Changes in the volumes of intracellular membrane-limited subcompartments can also be measured. Quantitative analysis of freeze-fractured membrane replicas can be carried out either by a statistical approach or by optical diffraction. In this way, physiological perturbations or developmental events leading to changes in membrane permeability can be studied for correlated changes in membrane structure.

scholarly journals Hypothesis: The Role of Sterols in Autism Spectrum Disorder

2011 ◽  
Vol 2011 ◽  
pp. 1-7 ◽  
Author(s):  
Ryan W. Y. Lee ◽  
Elaine Tierney
Keyword(s):  
Autism Spectrum Disorder ◽  
Sonic Hedgehog ◽  
Autism Spectrum ◽  
Membrane Lipid ◽  
Molecular Techniques ◽  
Spectrum Disorder ◽  
Advanced Imaging ◽  
Opitz Syndrome ◽  
Membrane Physiology

A possible role for sterols in the development of autism spectrum disorder (ASD) has not been proven, but studies in disorders of sterol biosynthesis, chiefly Smith-Lemli-Opitz syndrome (SLOS), enable hypotheses on a causal relationship to be discussed. Advances in genetic technology coupled with discoveries in membrane physiology have led to renewed interest for lipids in the nervous system. This paper hypothesizes on the role of sterol dysfunction in ASD through the framework of SLOS. Impaired sonic hedgehog patterning, alterations in membrane lipid rafts leading to abnormal synaptic plasticity, and impaired neurosteroid synthesis are discussed. Potential therapeutic agents include the development of neuroactive steroid-based agents and enzyme-specific drugs. Future investigations should reveal the specific mechanisms underlying sterol dysfunction in neurodevelopmental disorders by utilizing advanced imaging and molecular techniques.

Cor triatriatum sinistrum diagnosed in the adulthood: a systematic review

Heart ◽  
2019 ◽  
pp. heartjnl-2019-314714 ◽  
Author(s):  
Virginija Rudienė ◽  
Cristel M S Hjortshøj ◽  
Sigita Glaveckaitė ◽  
Diana Zakarkaitė ◽  
Žaneta Petrulionienė ◽  
...  
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Congestive Heart Failure ◽  
Natural History ◽  
Cor Triatriatum ◽  
Interventional Treatment ◽  
Cardiac Defects ◽  
First Choice ◽  
History Of ◽  
Membrane Physiology

BackgroundWe performed a systematic review of cor triatriatum sinistrum (CTS) diagnosed in adults. The aim of this review was to describe the clinical presentation, natural history and management of this congenital heart disease.MethodsA PubMed literature search for ‘cor triatriatum sinistrum’ published since 2005 was performed. Included patients were divided into those with and without obstructive membrane physiology. The clinical course differences were compared.ResultsA total of 171 published cases were included. The median age at diagnosis was 43 years (IQR, 30–60). Obstructive membrane physiology was observed in 70 (41%), and this patient group was younger at presentation (median age 39 (IQR, 28–52) vs 50 years (IQR, 32–64), p=0.003).Patients with obstructive membrane more frequently had associated cardiac defects (58.6% vs 42.4%, p=0.039). Overall, the most frequent clinical symptom was atrial fibrillation, as this was present in 56 (32.8%) of all patients. CTS-related symptoms were more frequent in patients with obstructive membrane: congestive heart failure (44.3% vs 15.2%, p<0.001), pulmonary hypertension (27.1% vs 6.1%, p<0.001), haemorrhage (8.6% vs 0%, p=0.004) and infections manifestation (8.6% vs 0%, p=0.004).A total of 71 (41.5%) patients with CTS required interventional treatment, mainly within patients with the obstructive membrane (86.8% vs 12.6%, p<0.001).ConclusionThe natural history of CTS most often manifests with symptoms of congestive heart failure. Patients with obstructive membrane most often have associated cardiac defects and higher risk for infections and haemorrhage. The interventional treatment of CTS remains the first choice for obstructive membrane.

Cell and Membrane Physiology

1981 ◽  
Vol 43 (1) ◽  
pp. 477-477
Author(s):  
J Gergely
Keyword(s):  
Membrane Physiology
Sign in / Sign up

Export Citation Format

Share Document