scholarly journals Sishen Pill Treatment of DSS-Induced Colitis via Regulating Interaction With Inflammatory Dendritic Cells and Gut Microbiota

2020 ◽  
Vol 11 ◽  
Author(s):  
Fang Chen ◽  
Yu-Ting Yin ◽  
Hai-Mei Zhao ◽  
Hai-Yan Wang ◽  
You-Bao Zhong ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Gut Microbiota ◽  
Inflammatory Dendritic Cells

Amelioration of allergic airway inflammation in mice by regulatory IL-35 through dampening inflammatory dendritic cells

Allergy ◽  
2015 ◽  
Vol 70 (8) ◽  
pp. 921-932 ◽  
Author(s):  
J. Dong ◽  
C. K. Wong ◽  
Z. Cai ◽  
D. Jiao ◽  
M. Chu ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Airway Inflammation ◽  
Allergic Airway Inflammation ◽  
Inflammatory Dendritic Cells

scholarly journals Systemic Antibiotic Therapy Reduces Circulating Inflammatory Dendritic Cells and Treg–Th17 Plasticity in Periodontitis

2019 ◽  
Vol 202 (9) ◽  
pp. 2690-2699 ◽  
Author(s):  
Mythilypriya Rajendran ◽  
Stephen Looney ◽  
Nagendra Singh ◽  
Mahmoud Elashiry ◽  
Mohamed M. Meghil ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Antibiotic Therapy ◽  
Systemic Antibiotic ◽  
Systemic Antibiotic Therapy ◽  
Inflammatory Dendritic Cells

scholarly journals Single-Cell Analysis of Human Mononuclear Phagocytes Reveals Subset-Defining Markers and Identifies Circulating Inflammatory Dendritic Cells

Immunity ◽  
2019 ◽  
Vol 51 (3) ◽  
pp. 573-589.e8 ◽  
Author(s):  
Charles-Antoine Dutertre ◽  
Etienne Becht ◽  
Sergio Erdal Irac ◽  
Ahad Khalilnezhad ◽  
Vipin Narang ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Single Cell ◽  
Single Cell Analysis ◽  
Mononuclear Phagocytes ◽  
Cell Analysis ◽  
Inflammatory Dendritic Cells

scholarly journals Transcriptomic microRNA Profiling of Dendritic Cells in Response to Gut Microbiota-Secreted Vesicles

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1534
Author(s):  
Natalia Díaz-Garrido ◽  
Sarah Bonnin ◽  
Marta Riera ◽  
Rosa Gíménez ◽  
Josefa Badia ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Gut Microbiota ◽  
Target Genes ◽  
Membrane Vesicles ◽  
Fine Tuning ◽  
Differentially Expressed ◽  
Health And Nutrition ◽  
Transcriptional Regulatory ◽  
Differentially Expressed Mirnas ◽  
Key Factor

The interconnection between nutrients, metabolites and microbes is a key factor governing the healthy/pathological status of an individual. Thus, microbiota-based research is essential in order to better understand human health and nutrition. Gut bacteria release membrane vesicles (MVs) as an intercellular communication mechanism that allows the direct delivery of factors that prime the host’s innate immune system. We have previously shown that MVs from intestinal E. coli activate dendritic cells (DCs) in a strain-specific manner. To gain insights into the regulatory mechanisms involved, here, we have used an RNA deep sequencing approach to identify differentially expressed miRNAs (microRNAs) in DCs which are challenged by the MVs of the probiotic Nissle 1917 (EcN) or the commensal ECOR12. MicroRNAs are post-transcriptional regulatory mediators that permit the fine tuning of signaling pathways. This approach allowed the identification of a common set of miRNAs which are modulated by MVs from both strains and miRNAs which are differentially expressed in response to EcN or ECOR12 MVs. Based on the differential expression of the target genes and subsequent validation experiments, we correlated some of the selected miRNAs with the reported cytokine profile and specific T cell responses. As far as we know, this is the first study to analyze the regulation of miRNAs in DCs by MVs released by gut microbiota.

CX3CR1-expressing inflammatory dendritic cells contribute to the progression of steatohepatitis

2015 ◽  
Vol 129 (9) ◽  
pp. 797-808 ◽  
Author(s):  
Salvatore Sutti ◽  
Irene Locatelli ◽  
Stefania Bruzzì ◽  
Aastha Jindal ◽  
Marco Vacchiano ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Hepatic Inflammation ◽  
Alcoholic Steatohepatitis ◽  
Inflammatory Dendritic Cells

We found that moDCs (monocyte-derived dendritic cells) sustain hepatic inflammation during the progression of experimental NASH (non-alcoholic steatohepatitis).

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