scholarly journals IBD and Bile Acid Absorption: Focus on Pre-clinical and Clinical Observations

2020 ◽  
Vol 11 ◽  
Author(s):  
Leo R. Fitzpatrick ◽  
Paniz Jenabzadeh
Keyword(s):  
Bile Acid ◽  
Acid Absorption ◽  
Clinical Observations ◽  
Bile Acid Absorption

scholarly journals Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

2008 ◽  
Vol 295 (1) ◽  
pp. G179-G186 ◽  
Author(s):  
Nazzareno Ballatori ◽  
Fang Fang ◽  
Whitney V. Christian ◽  
Na Li ◽  
Christine L. Hammond
Keyword(s):  
Bile Acid ◽  
Intraperitoneal Administration ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulfate ◽  
Acid Synthesis ◽  
Negative Regulator ◽  
Α Subunit ◽  
Acid Absorption ◽  
Bile Acid Absorption ◽  
Organic Solute

Mice deficient in the organic solute transporter (Ost)-α subunit of the heteromeric organic solute and steroid transporter, Ostα-Ostβ, were generated and were found to be viable and fertile but exhibited small intestinal hypertrophy and growth retardation. Bile acid pool size and serum levels were decreased by more than 60% in Ostα−/− mice, whereas fecal bile acid excretion was unchanged, suggesting a defect in intestinal bile acid absorption. In support of this hypothesis, when [3H]taurocholic acid or [3H]estrone 3-sulfate were administered into the ileal lumen, absorption was lower in Ostα−/− mice. Interestingly, serum cholesterol and triglyceride levels were also ∼15% lower in Ostα−/− mice, an effect that may be related to the impaired intestinal bile acid absorption. After intraperitoneal administration of [3H]estrone 3-sulfate or [3H]dehydroepiandrosterone sulfate, Ostα−/− mice had higher levels of radioactivity in their liver and urinary bladder and less in the duodenum, indicating altered hepatic, renal, and intestinal disposition. Loss of Ostα was associated with compensatory changes in the expression of several genes involved in bile acid homeostasis, including an increase in the multidrug resistance-associated protein 3, ( Mrp3)/ Abcc3, an alternate basolateral bile acid export pump, and a decrease in cholesterol 7α-hydroxylase, Cyp7a1, the rate-limiting enzyme in bile acid synthesis. The latter finding may be explained by increased ileal expression of fibroblast growth factor 15 ( Fgf15), a negative regulator of hepatic Cyp7a1 transcription. Overall, these findings provide direct support for the hypothesis that Ostα-Ostβ is a major basolateral transporter of bile acids and conjugated steroids in the intestine, kidney, and liver.

Measurement of 75Se-SeHCAT Abdominal Retention in the Initial Diagnosis of Bile Acid Absorption (BAM)

2011 ◽  
Vol 30 (5) ◽  
pp. 297-300
Author(s):  
P.C. Notta ◽  
D. Ramal ◽  
S. Maisterra ◽  
A. Rodríguez Gasen ◽  
S. Maymó ◽  
...  
Keyword(s):  
Bile Acid ◽  
Initial Diagnosis ◽  
Acid Absorption ◽  
Bile Acid Absorption

Generation of a Novel Antibody Probe to the Apical Sodium-Dependent Bile Acid Transporter That Inhibits Ileal Bile Acid Absorption

2009 ◽  
Vol 6 (3) ◽  
pp. 1012-1018 ◽  
Author(s):  
M. Montagnani ◽  
A. Marangoni ◽  
A. Roda ◽  
F. Azzaroli ◽  
G. Mazzella ◽  
...  
Keyword(s):  
Bile Acid ◽  
Acid Absorption ◽  
Bile Acid Absorption ◽  
Sodium Dependent ◽  
Bile Acid Transporter ◽  
Acid Transporter

Site of bile acid absorption in the rat

Lipids ◽  
1976 ◽  
Vol 11 (6) ◽  
pp. 467-471 ◽  
Author(s):  
D. Sklan ◽  
P. Budowski ◽  
S. Hurwitz
Keyword(s):  
Bile Acid ◽  
Acid Absorption ◽  
Bile Acid Absorption

Bile acid absorption in isolated bile duct units (IBDU) is primarily due to the apical bile acid transporter

2000 ◽  
Vol 118 (4) ◽  
pp. A930
Author(s):  
Gianfranco Alpini ◽  
Shannon Glaser ◽  
Jo Lynne Phinizy ◽  
Alan F. Hofmann ◽  
Gene LeSage
Keyword(s):  
Bile Acid ◽  
Bile Duct ◽  
Acid Absorption ◽  
Bile Acid Absorption ◽  
Bile Acid Transporter ◽  
Acid Transporter
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