scholarly journals Gestational Perfluorooctanoic Acid Exposure Inhibits Placental Development by Dysregulation of Labyrinth Vessels and uNK Cells and Apoptosis in Mice

2020 ◽  
Vol 11 ◽  
Author(s):  
Wenyu Jiang ◽  
Yu Deng ◽  
Zifan Song ◽  
Yajuan Xie ◽  
Lixin Gong ◽  
...  
Keyword(s):  
Perfluorooctanoic Acid ◽  
Acid Exposure ◽  
Placental Development ◽  
Unk Cells

Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children

Chemosphere ◽  
2019 ◽  
Vol 231 ◽  
pp. 25-31 ◽  
Author(s):  
Hui-Ju Wen ◽  
Shu-Li Wang ◽  
Yu-Chen Chuang ◽  
Pau-Chung Chen ◽  
Yue Leon Guo
Keyword(s):  
Atopic Dermatitis ◽  
Early Onset ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure

scholarly journals The Roles of Uterine Natural Killer (NK) Cells and KIR/HLA-C Combination in the Development of Preeclampsia: A Systematic Review

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Xiuhua Yang ◽  
Yahui Yang ◽  
Yiru Yuan ◽  
Lin Liu ◽  
Tao Meng
Keyword(s):  
Nk Cells ◽  
Natural Killer ◽  
Systemic Disease ◽  
Killer Cell ◽  
Inflammatory Factors ◽  
Placental Development ◽  
Multiple Organs ◽  
Unk Cells ◽  
Exact Etiology ◽  
Uterine Natural Killer

Preeclampsia (PE) is termed as a systemic disease that involves multiple organs; however, the exact etiology is still quite unclear. It is believed that the poor remodeling of uterine spiral arteries triggers PE, thereby causing failed placentation and producing inflammatory factors. The decline of blood flow results in lowering the nutrients and oxygen received by the fetus and augmenting the placental pressure in PE. Decidual immune cells, especially uterine natural killer (uNK) cells, are involved in the process of placentation. Decidual NK (dNK) cells significantly contribute to the vascular remodeling through the secretion of cytokines and angiogenic mediators in normal placental development. The abnormal activation of NK cells in both the peripheral blood and the decidua was counted among the causes leading to PE. The correlation existing between maternal killer cell immunoglobulin-like receptor (KIR) and HLA-C in trophoblast cells constitutes a robust evidence for the genetic etiology of PE. The combinations of the two kinds of gene systems, together with the KIR genotype in the mother and the HLA-C group in her fetus, are likely to exactly decide the pregnancy outcome. The women, who have the inappropriate match of KIR/HLA-C, are likely to be prone to the augmented risk of PE. However, the combinations of KIR/HLA-C in PE undergo ethnic changes. The extensive prospective research works in Europe, Asia, and Africa are required for providing more findings in PE patients.

scholarly journals Perfluorooctanoic acid exposure triggers oxidative stress in the mouse pancreas

2014 ◽  
Vol 1 ◽  
pp. 513-521 ◽  
Author(s):  
Lisa M. Kamendulis ◽  
Qiangen Wu ◽  
George E. Sandusky ◽  
Barbara A. Hocevar
Keyword(s):  
Oxidative Stress ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure ◽  
Mouse Pancreas

Perfluorooctanoic acid exposure disturbs glucose metabolism in mouse liver

2017 ◽  
Vol 335 ◽  
pp. 41-48 ◽  
Author(s):  
Fei Zheng ◽  
Nan Sheng ◽  
Hongxia Zhang ◽  
Shengmin Yan ◽  
Jianhai Zhang ◽  
...  
Keyword(s):  
Glucose Metabolism ◽  
Mouse Liver ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure

Relation between perfluorooctanoic acid exposure and strokes in a large cohort living near a chemical plant

2013 ◽  
Vol 127 ◽  
pp. 22-28 ◽  
Author(s):  
Chris Simpson ◽  
Andrea Winquist ◽  
Cathy Lally ◽  
Kyle Steenland
Keyword(s):  
Perfluorooctanoic Acid ◽  
Chemical Plant ◽  
Large Cohort ◽  
Acid Exposure

scholarly journals Physical activity modifies the association between prenatal perfluorooctanoic acid exposure and adolescent cardiometabolic risk

2021 ◽  
Vol 2021 (1) ◽  
Author(s):  
Joseph M. Braun ◽  
Nan Li ◽  
Yun Liu ◽  
Jessie Buckley ◽  
Kim Cecil ◽  
...  
Keyword(s):  
Physical Activity ◽  
Cardiometabolic Risk ◽  
Perfluorooctanoic Acid ◽  
Acid Exposure
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