scholarly journals The Biological Clock in Gray Mouse Lemur: Adaptive, Evolutionary and Aging Considerations in an Emerging Non-human Primate Model

2019 ◽  
Vol 10 ◽  
Author(s):  
Clara Hozer ◽  
Fabien Pifferi ◽  
Fabienne Aujard ◽  
Martine Perret
Keyword(s):  
Biological Clock ◽  
Mouse Lemur ◽  
Primate Model ◽  
Gray Mouse Lemur ◽  
Human Primate

The grey mouse lemur: A non-human primate model for ageing studies

2012 ◽  
Vol 11 (1) ◽  
pp. 150-162 ◽  
Author(s):  
S. Languille ◽  
S. Blanc ◽  
O. Blin ◽  
C.I. Canale ◽  
A. Dal-Pan ◽  
...  
Keyword(s):  
Mouse Lemur ◽  
Primate Model ◽  
Grey Mouse Lemur ◽  
Human Primate

The gray mouse lemur, a primate model for pluridisciplinary approaches on aging

2007 ◽  
Vol 42 (1-2) ◽  
pp. 144-145
Author(s):  
M. Perret ◽  
I. Hardy ◽  
F. Aujard
Keyword(s):  
Mouse Lemur ◽  
Primate Model ◽  
Gray Mouse Lemur

Effects of Dietary Resveratrol on the Sleep-Wake Cycle in the Non-Human Primate Gray Mouse Lemur (Microcebus murinus)*

2012 ◽  
Vol 29 (3) ◽  
pp. 261-270 ◽  
Author(s):  
F. Pifferi ◽  
A. Rahman ◽  
S. Languille ◽  
A. Auffret ◽  
C. Babiloni ◽  
...  
Keyword(s):  
Mouse Lemur ◽  
Microcebus Murinus ◽  
Gray Mouse Lemur ◽  
Human Primate

Cardiac Pacing in a Chronically Instrumented Non-Human Primate Model During Centrifuge,

1996 ◽  
Author(s):  
S. C. Koenig ◽  
Craig Reister ◽  
J. Schtaub ◽  
Gary Muniz ◽  
Tim Fergusan
Keyword(s):  
Cardiac Pacing ◽  
Primate Model ◽  
Human Primate

Combined therapy of mesenchymal stem cells with a GLP-1 receptor agonist, liraglutide, on an inflammatory-mediated diabetic non-human primate model

Life Sciences ◽  
2021 ◽  
Vol 276 ◽  
pp. 119374
Author(s):  
Roghayeh Navabi ◽  
Babak Negahdari ◽  
Ensiyeh Hajizadeh-Saffar ◽  
Mostafa Hajinasrollah ◽  
Yaser Jenab ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Receptor Agonist ◽  
Combined Therapy ◽  
Primate Model ◽  
Human Primate

scholarly journals Neonatal Immune System Ontogeny: The Role of Maternal Microbiota and Associated Factors. How Might the Non-Human Primate Model Enlighten the Path?

Vaccines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 584
Author(s):  
Natalia Nunez ◽  
Louis Réot ◽  
Elisabeth Menu
Keyword(s):  
Immune System ◽  
Mode Of Delivery ◽  
Microbial Colonization ◽  
Therapeutic Interventions ◽  
Primate Model ◽  
Neonatal Immune System ◽  
Gastrointestinal Colonization ◽  
The Impact ◽  
Human Primate

Interactions between the immune system and the microbiome play a crucial role on the human health. These interactions start in the prenatal period and are critical for the maturation of the immune system in newborns and infants. Several factors influence the composition of the infant’s microbiota and subsequently the development of the immune system. They include maternal infection, antibiotic treatment, environmental exposure, mode of delivery, breastfeeding, and food introduction. In this review, we focus on the ontogeny of the immune system and its association to microbial colonization from conception to food diversification. In this context, we give an overview of the mother–fetus interactions during pregnancy, the impact of the time of birth and the mode of delivery, the neonate gastrointestinal colonization and the role of breastfeeding, weaning, and food diversification. We further review the impact of the vaccination on the infant’s microbiota and the reciprocal case. Finally, we discuss several potential therapeutic interventions that might help to improve the newborn and infant’s health and their responses to vaccination. Throughout the review, we underline the main scientific questions that are left to be answered and how the non-human primate model could help enlighten the path.

scholarly journals Combination therapy protects macaques against advanced Marburg virus disease

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Robert W. Cross ◽  
Zachary A. Bornholdt ◽  
Abhishek N. Prasad ◽  
Viktoriya Borisevich ◽  
Krystle N. Agans ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Rhesus Monkeys ◽  
Viral Infections ◽  
Virus Disease ◽  
Marburg Virus ◽  
Therapeutic Window ◽  
Post Inoculation ◽  
Primate Model ◽  
Lethal Infection ◽  
Human Primate

AbstractMonoclonal antibodies (mAbs) and remdesivir, a small-molecule antiviral, are promising monotherapies for many viruses, including members of the genera Marburgvirus and Ebolavirus (family Filoviridae), and more recently, SARS-CoV-2. One of the major challenges of acute viral infections is the treatment of advanced disease. Thus, extending the window of therapeutic intervention is critical. Here, we explore the benefit of combination therapy with a mAb and remdesivir in a non-human primate model of Marburg virus (MARV) disease. While rhesus monkeys are protected against lethal infection when treatment with either a human mAb (MR186-YTE; 100%), or remdesivir (80%), is initiated 5 days post-inoculation (dpi) with MARV, no animals survive when either treatment is initiated alone beginning 6 dpi. However, by combining MR186-YTE with remdesivir beginning 6 dpi, significant protection (80%) is achieved, thereby extending the therapeutic window. These results suggest value in exploring combination therapy in patients presenting with advanced filovirus disease.

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