scholarly journals Asymmetric Dimethylarginine at Sea Level Is a Predictive Marker of Hypoxic Pulmonary Arterial Hypertension at High Altitude

2019 ◽  
Vol 10 ◽  
Author(s):  
Patricia Siques ◽  
Julio Brito ◽  
Edzard Schwedhelm ◽  
Eduardo Pena ◽  
Fabiola León-Velarde ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
High Altitude ◽  
Sea Level ◽  
Asymmetric Dimethylarginine ◽  
Predictive Marker ◽  
Pulmonary Arterial

scholarly journals Increased levels of asymmetric dimethylarginine are associated with pulmonary arterial hypertension in HIV infection

AIDS ◽  
2014 ◽  
Vol 28 (4) ◽  
pp. 511-519 ◽  
Author(s):  
Rushi V. Parikh ◽  
Rebecca Scherzer ◽  
Elaine M. Nitta ◽  
Anna Leone ◽  
Sophia Hur ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Hiv Infection ◽  
Arterial Hypertension ◽  
Asymmetric Dimethylarginine ◽  
Pulmonary Arterial

scholarly journals Residence at moderately high altitude and its relationship with WHO Group 1 pulmonary arterial hypertension symptom severity and clinical characteristics: the Pulmonary Hypertension Association Registry

2020 ◽  
Vol 10 (4) ◽  
pp. 204589402096434
Author(s):  
Shoaib Fakhri ◽  
Kelly Hannon ◽  
Kelly Moulden ◽  
Ryan Peterson ◽  
Peter Hountras ◽  
...  
Keyword(s):  
Pulmonary Hypertension ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
High Altitude ◽  
Clinical Characteristics ◽  
Supplemental Oxygen ◽  
Walk Distance ◽  
Pulmonary Arterial ◽  
Low Altitude ◽  
Group 1

Background WHO Group 1 pulmonary arterial hypertension is a progressive and potentially fatal disease. Individuals living at higher altitude are exposed to lower barometric pressure and hypobaric hypoxemia. This may result in pulmonary vasoconstriction and contribute to disease progression. We sought to examine the relationship between living at moderately high altitude and pulmonary arterial hypertension characteristics. Methods Forty-two US centers participating in the Pulmonary Hypertension Association Registry enrolled patients who met the definition of WHO Group 1 pulmonary arterial hypertension. We utilized baseline data and patient questionnaire responses. Patients were divided into two groups: moderately high altitude residence (home ≥4000 ft) and low altitude residence (home <4000 ft) based on zip-code. Clinical characteristics, hemodynamic data, patient demographics, and patient reported quality of life metrics were compared. Results Controlling for potential confounders (age, sex at birth, body mass index, supplemental oxygen use, race, 100-day cigarette use, alcohol use, and pulmonary arterial hypertension medication use), subjects residing at moderately high altitude had a 6-min walk distance 32 m greater than those at low altitude, despite having a pulmonary vascular resistance that was 2.2 Wood units higher. Additionally, those residing at moderately high altitude had 3.7 times greater odds of using supplemental oxygen. Conclusion Patients with pulmonary arterial hypertension who live at moderately high altitude have a higher pulmonary vascular resistance and are more likely to need supplemental oxygen. Despite these findings, moderately high altitude Pulmonary Hypertension Association Registry patients have better functional tolerance as measured by 6-min walk distance. It is possible that a “high-altitude phenotype” of pulmonary arterial hypertension may exist. These findings warrant further study.

Common genetic basis for pulmonary arterial hypertension and high altitude pulmonary edema

Pneumologie ◽  
2018 ◽  
Vol 72 (S 01) ◽  
pp. S64-S64
Author(s):  
C Eichstaedt ◽  
H Mairbäurl ◽  
J Song ◽  
N Benjamin ◽  
C Fischer ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Edema ◽  
High Altitude ◽  
Genetic Basis ◽  
High Altitude Pulmonary Edema ◽  
Pulmonary Arterial

Common genetic basis for pulmonary arterial hypertension and high altitude pulmonary edema

2018 ◽  
Author(s):  
Christina Eichstaedt ◽  
Heimo Mairbäurl ◽  
Jie Song ◽  
Nicola Benjamin ◽  
Christine Fischer ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Pulmonary Edema ◽  
High Altitude ◽  
Genetic Basis ◽  
High Altitude Pulmonary Edema ◽  
Pulmonary Arterial

The newborn sheep translational model for pulmonary arterial hypertension of the neonate at high altitude

2020 ◽  
Vol 11 (5) ◽  
pp. 452-463 ◽  
Author(s):  
Alejandro Gonzaléz-Candia ◽  
Alejandro A. Candia ◽  
Germán Ebensperger ◽  
Roberto V. Reyes ◽  
Aníbal J. Llanos ◽  
...  
Keyword(s):  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
High Altitude ◽  
Vascular Dysfunction ◽  
Cardiovascular Development ◽  
Perinatal Complications ◽  
Translational Model ◽  
Sheep Model ◽  
Pulmonary Arterial ◽  
Low Prevalence

AbstractChronic hypoxia during gestation induces greater occurrence of perinatal complications such as intrauterine growth restriction, fetal hypoxia, newborn asphyxia, and respiratory distress, among others. This condition may also cause a failure in the transition of the fetal to neonatal circulation, inducing pulmonary arterial hypertension of the neonate (PAHN), a syndrome that involves pulmonary vascular dysfunction, increased vasoconstrictor tone and pathological remodeling. As this syndrome has a relatively low prevalence in lowlands (~7 per 1000 live births) and very little is known about its prevalence and clinical evolution in highlands (above 2500 meters), our understanding is very limited. Therefore, studies on appropriate animal models have been crucial to comprehend the mechanisms underlying this pathology. Considering the strengths and weaknesses of any animal model of human disease is fundamental to achieve an effective and meaningful translation to clinical practice. The sheep model has been used to study the normal and abnormal cardiovascular development of the fetus and the neonate for almost a century. The aim of this review is to highlight the advances in our knowledge on the programming of cardiopulmonary function with the use of high-altitude newborn sheep as a translational model of PAHN.

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