scholarly journals The Relationship Between Heart Rate and Left Ventricular Isovolumic Relaxation During Normoxia and Hypoxia-Asphyxia in Newborn Piglets

2019 ◽  
Vol 10 ◽  
Author(s):  
Wei Shen ◽  
Xin Xu ◽  
Tze-Fun Lee ◽  
Georg Schmölzer ◽  
Po-Yin Cheung
Keyword(s):  
Heart Rate ◽  
Left Ventricular ◽  
Newborn Piglets ◽  
The Relationship ◽  
Isovolumic Relaxation

Influence of heart rate on left ventricular isovolumic relaxation time: a Doppler study in healthy newborns

2004 ◽  
Vol 17 (4) ◽  
pp. 330-331 ◽  
Author(s):  
Antonio De Merulis ◽  
Giulio Calcagni ◽  
Paolo Versacci ◽  
Renato Lucchini ◽  
Flavia Ventriglia ◽  
...  
Keyword(s):  
Heart Rate ◽  
Relaxation Time ◽  
Left Ventricular ◽  
Isovolumic Relaxation Time ◽  
Doppler Study ◽  
Isovolumic Relaxation

scholarly journals Childhood and adult exposure to secondhand tobacco smoke and cardiac structure and function: results from Echo-SOL

Open Heart ◽  
2018 ◽  
Vol 5 (2) ◽  
pp. e000831 ◽  
Author(s):  
Melissa Suzanne Burroughs Peña ◽  
Katrina Swett ◽  
Robert C Kaplan ◽  
Krista Perreira ◽  
Martha Daviglus ◽  
...  
Keyword(s):  
Left Ventricular ◽  
Structure And Function ◽  
Cardiac Structure ◽  
Isovolumic Relaxation Time ◽  
Shs Exposure ◽  
Cardiac Structure And Function ◽  
And Function ◽  
Relationship Of ◽  
The Relationship ◽  
Isovolumic Relaxation

ObjectiveTo describe the relationship of household secondhand smoke (SHS) exposure and cardiac structure and function.MethodsParticipants (n=1069; 68 % female; age 45–74 years) without history of tobacco use, coronary artery disease or severe valvular disease were included. Past childhood (starting at age <13 years), adolescent/adult and current exposure to household SHS was assessed. Survey linear regression analyses were used to model the relationship of SHS exposure and echocardiographic measures of cardiac structure and function, adjusting for covariates (age, sex, study site, alcohol use, physical activity and education).ResultsSHS exposure in childhood only was associated with reduced E/A velocity ratio (β=−0.06 (SE 0.02), p=0.008). SHS exposure in adolescence/adult only was associated with increased left ventricular ejection fraction (LVEF) (1.2 (0.6), p=0.04), left atrial volume index (1.7 (0.8), p=0.04) and decreased isovolumic relaxation time (−0.003 (0.002), p=0.03). SHS exposure in childhood and adolescence/adult was associated with worse left ventricular global longitudinal strain (LVGLS) (two-chamber) (0.8 (0.4), p= 0.049). Compared with individuals who do not live with a tobacco smoker, individuals who currently live with at least one tobacco smoker had reduced LVEF (−1.4 (0.6), p=0.02), LVGLS (average) (0.9 (0.40), p=0.03), medial E′ velocity (−0.5 (0.2), p=0.01), E/A ratio (−0.09 (0.03), p=0.003) and right ventricular fractional area change (−0.02 (0.01), p=0.01) with increased isovolumic relaxation time (0.006 (0.003), p=0.04).ConclusionsPast and current household exposure to SHS was associated with abnormalities in cardiac systolic and diastolic function. Reducing household SHS exposure may be an opportunity for cardiac dysfunction prevention to reduce the risk of future clinical heart failure.

Adverse Effects of Hypoxaemia on Diastolic Filling in Humans

1995 ◽  
Vol 89 (2) ◽  
pp. 165-169 ◽  
Author(s):  
Robert I. Cargill ◽  
David G. Kiely ◽  
Brian J. Lipworth
Keyword(s):  
Heart Rate ◽  
Relaxation Time ◽  
Confidence Interval ◽  
Left Ventricular ◽  
Mean Difference ◽  
Oxygen Mixture ◽  
Diastolic Filling ◽  
Isovolumic Relaxation Time ◽  
Isovolumic Relaxation ◽  
Deceleration Time

1. Abnormalities of myocardial relaxation may occur as a consequence of myocyte hypoxia. We have therefore examined the effects of hypoxaemia on right and left ventricular diastolic function in 10 healthy male subjects. 2. After resting to reach baseline haemodynamics, subjects were rendered hypoxaemic by breathing a variable nitrogen/oxygen mixture. Oxygen saturation (SaO2) was maintained at 85–90% for 20 min and then at 75–80% for a further 20 min. Haemodynamic and diastolic filling parameters were measured non-invasively at baseline and at the end of each period of hypoxaemia. 3. Diastolic filling of both ventricles was significantly impaired by hypoxaemia. In comparison with baseline, left ventricular isovolumic relaxation time and transmitral E-wave deceleration time corrected for heart rate were significantly prolonged at SaO2 75–80%: mean difference in corrected relaxation time, 9.8 ms (95% confidence interval 1–19); mean difference in corrected deceleration time, 34 ms (95% confidence interval 11–56). Similarly, right ventricular isovolumic relaxation time and transtricuspid E-wave deceleration time were significantly prolonged at SaO2 values of 75–80% compared with baseline: mean difference in relaxation time, 20.3 ms (95% confidence interval 3–38); mean difference in deceleration time, 33 ms (95% confidence interval 11–55). 4. During hypoxaemia there were dose-related increases in heart rate, cardiac output and mean pulmonary artery pressure, but no effects on mean arterial pressure. 5. Hypoxaemia significantly impairs relaxation of left and right ventricles in normal humans. These changes may reflect impairment of intracellular calcium transport secondary to the effects of myocyte hypoxia.

Peak Apical Recoil Rate is a Simplified Index of Left Ventricular Untwist: Validation and Application for Assessment of Diastolic Function in Children

2021 ◽  
Author(s):  
putri yubbu ◽  
Hunter Kauffman ◽  
Renzo Calderon-Anyosa ◽  
Andrea E. Monteroa ◽  
Tomoyuki Sato ◽  
...  
Keyword(s):  
Heart Rate ◽  
Healthy Subjects ◽  
Validation Cohort ◽  
Intraclass Correlation ◽  
Left Ventricular ◽  
Isovolumic Relaxation Time ◽  
Incremental Value ◽  
Pulmonary Capillary ◽  
Straight Leg Raising ◽  
Isovolumic Relaxation

Abstract AimsTo simplify measurement of untwist by measuring the recoil rate of LV apex only, to validate and apply peak apical recoil rate (PARR) as an index of diastolic dysfunction (DD) in pediatric subjects during increased and decreased lusitropic states. Methods and ResultsWe recruited 153 healthy subjects (mean age 13.8+2.9 years), of whom 48 performed straight leg raising exercise and an additional 46 patients (mean 8.4+5.6 years) with documented pulmonary capillary wedge pressures (PCWP) (validation cohort). In addition, we studied 16 dilated cardiomyopathy patients (mean age 9.5+6.3years) (application cohort). PARR and isovolumic relaxation time (IVRT) were compared to PCWP. Both PARR and PARR normalized by heart rate (nPARR) were excellent in detecting patient with PCWP >12 mmHg and greatly superior to IVRT in this respect (AUC: 0.98, 95% CI [0.96, 1.0] vs. AUC: 0.7 95%CI [0.54,0.86]). In DCM patients, PARR and nPARR were greatly decreased compared to controls (-38.58+18.59º/s vs -63.07+16.35º /s, p< 0.001) and (-0.43+0.20 º/ s/min vs -0.83+0.28º/s/min, p<0.0001) but increased with straight leg raising exercise (-59.4+19.4º/s vs -97.82+39.0 º/s, p<0.01) and -0.85+0.36 vs -1.4+0.62 º/s/min (p< 0.0001). The intra-observer and inter-observer intraclass correlation (ICC) coefficients were 0.95 and 0.88, respectively.ConclusionPARR successfully detected increased and decreased lusitropic states and was not affected by age when normalized with heart rate. Both PARR and nPARR are superior to IVRT in their correlation with PCWP and offer incremental value over traditional indices of DD. This highly reproducible parameter may potentially serve as a useful index of elevated PCWP in children.

Abstract 18692: Evolution of Diastolic Parameters and Their Relationship to Heart Rate in the 7-15 Week Human Fetus

Circulation ◽  
2015 ◽  
Vol 132 (suppl_3) ◽  
Author(s):  
Claudine M Bohun ◽  
Lisa Howley ◽  
Jesus Serrano Lomelin ◽  
Winnie Savard ◽  
Lindsay Mills ◽  
...  
Keyword(s):  
Heart Rate ◽  
Cardiac Cycle ◽  
Fetal Heart ◽  
Left Ventricular ◽  
Time Interval ◽  
Ejection Time ◽  
Systolic Time ◽  
Ventricular Filling ◽  
Diastolic Time ◽  
Isovolumic Relaxation

Objectives: Fetal echo offers a unique opportunity to investigate cardiac function in humans from the 1st trimester. We sought to explore the evolution left ventricular (LV) diastolic parameters and their relationship to fetal heart rate (HR) from 7-15 weeks gestational age (GA). Methods: We prospectively performed fetal echo in 137 healthy pregnancies recruited from 7+0 to 15+0 (mean 11.5±2.1) weeks GA. From Doppler studies we measured LV isovolumic relaxation time (IRT), mitral valve (MV) inflow patterns,and duration, diastolic time (IRT+inflow duration), LV ejection time (ET) and systolic time interval (isovolumic contraction time+ET). All variables were compared to GA and HR and were assessed as a proportion of the cardiac cycle length (R-R). Data were analyzed by regression and correlation analyses. Results: Results: From 7+0-15+0 weeks, HR and GA showed a non-linear relationship (R2=0.55, p<0.001) with low HRs at 7-8 weeks, peaking between 8-9 weeks, then falling thereafter. Diastolic time linearly increased with GA (R2=0.65, p<0.001) and inversely correlated with HR (r=0.77, p<0.001). IRT showed a nonlinear inverse relationship with GA (R2= 0.70, p<0.001), but did not correlate with HR, and IRT/RR increased linearly with GA (R2=0.71, p<0.001). Both inflow duration and inflow duration/R-R linearly increased with GA (R2=0.81,p<0.001). Inflow duration inversely correlated with HR (r=-0.70) and with IRT (r=-0.71) and IRT/R-R (r=-0.83, p<0.001 for all 3). A uniphasic MV atrial systolic inflow signal was present in 20/21 fetuses at 7+1-9+0 weeks, whereas, biphasic MV inflow was seen in 45% at 9+1-10+0 , 76% at 10+1-11+0 , 95% at 11+1-13+0 and 100% after 13+1 weeks GA. Inflow duration was significantly longer (146.9±25.4 vs 85.2±12.6ms, p<0.001) and HR was lower (160±9 vs 170±10 bpm, p<0.001) in fetuses with a biphasic flow pattern. ET demonstrated a weak relationship with GA (R2=0.41) and no relationship with HR, IVRT,or IVRT/R-R, and the systolic time showed a nonlinear trend of decreasing with GA (R2=0.46). Conclusions: In the 7-15 week fetus, improvements in relaxation suggested by decreasing IRT, decreasing HR, and, to a lesser extent, decreasing systolic time likely contribute to increasing inflow duration and to early ventricular filling.

Heart rate turbulence in mild-to-moderate aortic stenosis in boxers

2012 ◽  
Vol 15 (3) ◽  
pp. 477-481 ◽  
Author(s):  
A. Noszczyk-Nowak
Keyword(s):  
Heart Rate ◽  
Aortic Stenosis ◽  
Left Ventricular ◽  
Subaortic Stenosis ◽  
Cardiac Diseases ◽  
Heart Rate Turbulence ◽  
Echocardiographic Parameters ◽  
Healthy Dogs ◽  
Mass Factor ◽  
The Relationship

Abstract Heart rate turbulence (HRT) is a new electrocardiographic parameter used in human medicine to predict the possibility of death in patients with cardiac diseases. There is no information about HRT in healthy dogs and those with cardiac diseases. The aim of the present study was to compare the HRT in healthy Boxers dogs with Boxers with mild and moderate subaortic stenosis (SAS), to disclose the relationship between HRT and specific echocardiographic parameters and to evaluate if HRT can be used as a prognostic value in dogs with aortic stenosis. The study revealed significantly lower values of turbulence onset (TO) and turbulence slope (TS) HRT dogs with SAS (TO = -0.76 ± 2.6, TS = 7.1 ± 3.21) in compared with healthy dogs (TO = -7.45 ± 9.72, TS = 14.33 ± 8.76). TO values correlated with the left ventricular mass (LVM)/body mass factor (r = 0,32; p = 0.048). Based on the results obtained it can be stated that dogs with SAS have a compromised baroreceptor response, which can influence the mortality of the animals with described cardiac defect.

scholarly journals Cardiac Involvement in Thyroid Hormone Resistance

2002 ◽  
Vol 87 (1) ◽  
pp. 204-212 ◽  
Author(s):  
George J. Kahaly ◽  
Clare H. Matthews ◽  
Susanne Mohr-Kahaly ◽  
Chris A. Richards ◽  
V. Krishna K. Chatterjee
Keyword(s):  
Heart Rate ◽  
Thyroid Hormone ◽  
Ejection Fraction ◽  
Cardiac Involvement ◽  
Left Ventricular ◽  
Cardiac Response ◽  
Healthy Children ◽  
Cardiac Symptoms ◽  
Lv Ejection Fraction ◽  
Isovolumic Relaxation

To analyze the cardiovascular alterations thought to occur in resistance to thyroid hormone (RTH), cardiac involvement in 54 patients with RTH was investigated with the help of two-dimensional and Doppler echocardiography. Data from 41 of 54 adult subjects with RTH were also compared with those of 24 and 20 cases with hyperthyroidism (H) and hypothyroidism (h), respectively, as well as 22 healthy euthyroid controls (C). With respect to the type of mutations, no correlation was found between cardiovascular features and genotype. Compared with affected adults, children with RTH showed markedly higher serum free T3 (FT3), free T4 (FT4), and baseline TSH concentrations. Compared with healthy children of comparable age, RTH children had significantly higher heart rate and lower left ventricular (LV) ejection fraction (P = 0.006). Also, higher heart rate and FT4 as well as shorter diastolic relaxation of the myocardium (all P = 0.001) between RTH subjects with and without thyrotoxic cardiovascular features were found. Cardiac symptoms (palpitations, 32% vs. 71%) and signs (sinus tachycardia, 26% vs. 79%; atrial fibrillation, 6% vs. 17%) were significantly less frequent in RTH vs. H (all P = 0.001). Compared with C and h, heart rate, cardiac output, stroke volume, and systolic aortic flow velocity were strongly increased in RTH (all P = 0.0001) and H, although ejection (P = 0.0012) and shortening (P = 0.0001) fractions of the LV were markedly lower in RTH vs. H. Diastolic parameters, such as isovolumic relaxation (P = 0.0001) and deceleration time (P = 0.013), were shorter in RTH vs. h and C. In RTH, positive correlations between FT3 and heart rate, and between FT4 and LV ejection fraction were observed, whereas negative correlations between both FT3 and FT4 and isovolumic relaxation were noted. In conclusion, these findings indicate a modulated hyperthyroid effect on cardiac systolic and diastolic function of the myocardium in RTH, whereas other parameters, such as ejection and shortening fractions of the LV, systolic diameter, and LV wall thickness, were comparable to C. Differences in term of cardiovascular changes were smaller between the RTH and C groups than the RTH and the H or h groups. Thus, an incomplete cardiac response to thyroid hormone is present in RTH.

The relationship between heart rate variability and left ventricular layer-specific deformation in uncomplicated diabetic patients

2016 ◽  
Vol 33 (4) ◽  
pp. 481-490 ◽  
Author(s):  
Vladan Vukomanovic ◽  
Marijana Tadic ◽  
Jelena Suzic-Lazic ◽  
Vesna Kocijancic ◽  
Vera Celic
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Left Ventricular ◽  
Diabetic Patients ◽  
The Relationship
Sign in / Sign up

Export Citation Format

Share Document