scholarly journals Peritoneal Protein Clearance Is a Function of Local Inflammation and Membrane Area Whereas Systemic Inflammation and Comorbidity Predict Survival of Incident Peritoneal Dialysis Patients

2019 ◽  
Vol 10 ◽  
Author(s):  
Zanzhe Yu ◽  
Mark Lambie ◽  
James Chess ◽  
Andrew Williams ◽  
Jun-Young Do ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Systemic Inflammation ◽  
Local Inflammation ◽  
Dialysis Patients ◽  
Membrane Area ◽  
Protein Clearance ◽  
Peritoneal Protein Clearance

Peritoneal protein clearance predicts mortality in peritoneal dialysis patients

2018 ◽  
Vol 23 (4) ◽  
pp. 551-560
Author(s):  
Wanhong Lu ◽  
Wing-Fai Pang ◽  
Li Jin ◽  
Huixian Li ◽  
Kai Ming Chow ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Protein Clearance ◽  
Peritoneal Protein Clearance

scholarly journals Peritoneal Protein Clearance Rather than Faster Transport Status Determines Outcomes in Peritoneal Dialysis Patients

2015 ◽  
Vol 35 (2) ◽  
pp. 216-221 ◽  
Author(s):  
Gayathri Rajakaruna ◽  
Ben Caplin ◽  
Andrew Davenport
Keyword(s):  
Peritoneal Dialysis ◽  
Dialysis Patients ◽  
Therapy Failure ◽  
Risk Of Death ◽  
Inflammatory Conditions ◽  
Protein Clearance ◽  
Peritoneal Transport ◽  
Increased Risk ◽  
Pore Flow ◽  
Peritoneal Protein Clearance

Faster peritoneal transport has been associated with an increased risk of therapy failure and patient mortality. However, faster transport can the result of many factors. Peritoneal protein clearance (PPC) has been proposed to distinguish faster peritoneal transport attributable to inflammatory conditions, as protein clearance reflects large-pore flow, which increases during inflammation. We followed a cohort of 300 peritoneal dialysis patients, and after adjustments for age and comorbidity, higher PPC was associated with increased risk of death (hazard ratio: 1.81; 95% confidence interval: 1.11 to 2.95), even after patients underwent transplantation or transferred to hemodialysis.

Systemic Inflammation Induces Endothelial Dysfunction in Peritoneal Dialysis Patients

2008 ◽  
Vol 4 (1) ◽  
pp. 217-224
Author(s):  
Abelardo Aguilera ◽  
Eddy Velasquez ◽  
Maria A. Bajo ◽  
Maria L. Ruiz-Caravaca ◽  
Mario Pavone ◽  
...  
Keyword(s):  
Peritoneal Dialysis ◽  
Endothelial Dysfunction ◽  
Systemic Inflammation ◽  
Dialysis Patients

scholarly journals Association of Lean Body Mass Index and Peritoneal Protein Clearance in Peritoneal Dialysis Patients

2019 ◽  
Vol 44 (1) ◽  
pp. 94-102 ◽  
Author(s):  
Jinjin  Fan ◽  
Hongjian  Ye ◽  
Xiaodan  Zhang ◽  
Peiyi  Cao ◽  
Qunying  Guo ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Peritoneal Dialysis ◽  
Nutritional Status ◽  
Lean Body Mass ◽  
Body Mass ◽  
Creatinine Ratio ◽  
Protein Loss ◽  
Protein Clearance ◽  
The Relationship ◽  
Peritoneal Protein Clearance

Background/Aims: The relationship between peritoneal protein clearance (PPCl) and nutritional status in peritoneal dialysis (PD) population have not been clarified. This study aims to investigate the relationship between PPCl and nutritional status in PD population. Methods: Prevalent PD patients were enrolled in the cross-sectional survey in a single center from April to November 2013. The total amount of protein loss in the dialysate was calculated. PPCl reflects the individual differences of peritoneal protein loss, and is calculated by the formula, that PPCl (ml/day)=24-h dialysate protein loss / (albumin/0.4783). Nutritional status measured by lean body mass index (LBMI) was assessed by multi-frequency bioelectrical impedance analysis (BIA). Results: Totally 351 PD patients (55% male, 17.1% with diabetes, mean age 47.7±14.3 years) were included. The median PPC l was 58 ml/day. Patients were divided into four groups for comparison according to the PPC quartiles. Compared with lower PPCl quartiles, patients with higher PPCl had higher body mass index (BMI) (P< 0.001), body surface area (BSA) (P < 0 .001), LBMI (P<0.001), 4-hour D/P creatinine ratio (P< 0.001), and lower residual renal CCl (P<0.001). Compared with conventional body index (BMI and BSA) in ROC analysis, LBMI (area under curve: 0.71, 95% confidence interval [CI]: 0.66-0.77) had better performance in predicting higher PPCl. After adjustment in logistic regression models, each 1 kg/m2 increase of LBMI (odd ratio[OR] =1.37; 95% CI: 1.17-1.60), each 0.1 increase of 4-hour D/P creatinine ratio (OR =1.47; 95% CI: 1.11-1.93), and every 1 L/week/1.73m2 decrease of residual renal CCl (OR =0.98; 95% CI: 0.96-0.99) were independently associated with higher PPCl (> 58 ml/day). Conclusion: Higher LBMI was independently associated with higher , indicating that better nutritional status dominates peritoneal protein metabolism in PD patients.

scholarly journals Tissue sodium stores in peritoneal dialysis and hemodialysis patients determined by 23-sodium magnetic resonance imaging

2020 ◽  
Author(s):  
Melis Sahinoz ◽  
Supisara Tintara ◽  
Serpil Muge Deger ◽  
Aseel Alsouqi ◽  
Rachelle L Crescenzi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Peritoneal Dialysis ◽  
Magnetic Resonance ◽  
Systemic Inflammation ◽  
Multivariable Analysis ◽  
Sodium Content ◽  
Resonance Imaging ◽  
Dialysis Patients ◽  
Sodium Accumulation ◽  
Tissue Sodium

Abstract Background Tissue sodium content in patients on maintenance hemodialysis (MHD) and peritoneal dialysis (PD) were previously explored using 23Sodium magnetic resonance imaging (23NaMRI). Larger studies would provide a better understanding of sodium stores in patients on dialysis as well as the factors influencing this sodium accumulation. Methods In this cross-sectional study, we quantified the calf muscle and skin sodium content in 162 subjects (10 PD, 33 MHD patients, and 119 controls) using 23NaMRI. Plasma levels of interleukin-6 (IL-6) and high-sensitivity C-reactive protein (hsCRP) were measured to assess systemic inflammation. Sixty-four subjects had repeat 23NaMRI scans that were analyzed to assess the repeatability of the 23NaMRI measurements. Results Patients on MHD and PD exhibited significantly higher muscle and skin sodium accumulation compared to controls. African American patients on dialysis exhibited greater muscle and skin sodium content compared to non-African Americans. Multivariable analysis showed that older age was associated with both higher muscle and skin sodium. Male sex was also associated with increased skin sodium deposition. Greater ultrafiltration was associated with lower skin sodium in patients on PD (Spearman’s rho=-0.68, P = 0.035). Higher plasma IL-6 and hsCRP levels correlated with increased muscle and skin sodium content in the overall study population. Patients with higher baseline tissue sodium content exhibited greater variability in tissue sodium stores on repeat measurements. Conclusions Our findings highlight greater muscle and skin sodium content in dialysis patients compared to controls without kidney disease. Tissue sodium deposition and systemic inflammation seen in dialysis patients might influence one another bidirectionally.

Sign in / Sign up

Export Citation Format

Share Document