scholarly journals Circulating Apoptotic Signals During Acute and Chronic Exposure to High Altitude in Kyrgyz Population

2019 ◽  
Vol 10 ◽  
Author(s):  
Djuro Kosanovic ◽  
Simon Maximilian Platzek ◽  
Aleksandar Petrovic ◽  
Akylbek Sydykov ◽  
Abdirashit Maripov ◽  
...  
Keyword(s):  
High Altitude ◽  
Chronic Exposure ◽  
Acute And Chronic Exposure ◽  
Kyrgyz Population

Pharmacokinetics of prednisolone in man during acute and chronic exposure to high altitude

2005 ◽  
Vol 43 (02) ◽  
pp. 85-91 ◽  
Author(s):  
A. Arancibia ◽  
M.N. Gai ◽  
J. Chávez ◽  
C. Paulos ◽  
E. Pinilla ◽  
...  
Keyword(s):  
High Altitude ◽  
Chronic Exposure ◽  
Acute And Chronic Exposure

CATECHOLAMINE RESPONSE AT REST AND DURING EXERCISE AT SEA LEVEL, ACUTE AND CHRONIC EXPOSURE TO HIGH ALTITUDE.

1989 ◽  
Vol 21 (Supplement) ◽  
pp. S61 ◽  
Author(s):  
R. S. Mazzeo ◽  
G. A. Brooks ◽  
J. Sutton ◽  
G. Butterfield ◽  
G. Wolfel ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Chronic Exposure ◽  
Catecholamine Response ◽  
Acute And Chronic Exposure

Arterial catecholamine responses during exercise with acute and chronic high-altitude exposure

1991 ◽  
Vol 261 (4) ◽  
pp. E419-E424 ◽  
Author(s):  
R. S. Mazzeo ◽  
P. R. Bender ◽  
G. A. Brooks ◽  
G. E. Butterfield ◽  
B. M. Groves ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Neural Activity ◽  
Chronic Exposure ◽  
Physiological Responses ◽  
Submaximal Exercise ◽  
Altitude Exposure ◽  
Acute And Chronic Exposure ◽  
Over Time ◽  
Catecholamine Levels

Exercise at high altitude is a stress that activates the sympathoadrenal systems, which could affect responses to acute altitude exposure and promote adaptations during chronic altitude exposure. However, catecholamine levels are not clearly described over time at high altitude. In seven male volunteers (23 yr, 72 kg), resting arterial norepinephrine concentrations (ng/ml) on arrival at Pikes Peak (0.338 +/- 0.041) decreased compared with sea-level values (0.525 +/- 0.034) but increased to above sea-level values after 21 days at 4,300 m (0.798 +/- 0.052). Furthermore, during 45 min of constant submaximal exercise, values were similar at sea level (1.670 +/- 0.221) and on acute exposure to 4,300 m (2.123 +/- 0.086) but increased after 21 days of chronic exposure (2.693 +/- 0.216). By contrast, resting arterial epinephrine values (ng/ml) during acute and chronic exposure (0.708 +/- 0.033 vs. 0.448 +/- 0.026) both exceeded those of sea level (0.356 +/- 0.020). During exercise values on arrival were greater than at sea level (0.921 +/- 0.024 vs. 0.397 +/- 0.035) but fell to 0.612 +/- 0.025 ng/ml after 21 days. Exercise norepinephrine levels were related to systemic vascular resistance measurements (r = 0.93), whereas epinephrine levels were related to circulating lactate (r = 0.95). We conclude that during exercise at altitude there is a dissociation between norepinephrine, an indicator of sympathetic neural activity, and epinephrine, an indicator of adrenal medullary response. These actions may account for different metabolic and physiological responses to acute vs. chronic altitude exposure.

scholarly journals Effect of Acute and Chronic Exposure to High Altitude on the Aerobic and Anaerobic Metabolism in Rats

2015 ◽  
Vol 2015 ◽  
pp. 1-5 ◽  
Author(s):  
Qian Ni ◽  
Feng Qi Wan ◽  
Yu Hong Jing ◽  
Xiang Yu Dong ◽  
You Cheng Zhang
Keyword(s):  
High Altitude ◽  
Metabolic Pathway ◽  
Chronic Exposure ◽  
Anaerobic Metabolism ◽  
Hepatic Expression ◽  
Lactate Levels ◽  
Acute And Chronic Exposure ◽  
Stressful Environments ◽  
Major Metabolic Pathway ◽  
Aerobic And Anaerobic

In this study, we aimed to investigate the effect of acute and chronic exposure to HA on the aerobic and anaerobic metabolism in liver by determining the hepatic levels of ICDH and ATP. Lactate levels in liver and blood were also examined. Rats were exposed to an altitude of 4,300 m for 30 days, and those without HA exposure were used as controls. We observed an increased expression of liver ICDH following acute exposure (days 1, 3, and 7), whereas the liver ATP concentration was reduced on day 1. No changes in the hepatic expression of ICDH and ATP were found in rats chronically exposed to HA. Lactate concentrations of liver and blood did not show any significant changes following HA exposure. Thus, aerobic metabolism may be the major metabolic pathway in response to HA hypoxia in order to acclimatize themselves to the stressful environments.

Acclimatization to high altitude increase muscle sympathetic activity both at rest and during exercise

1995 ◽  
Vol 269 (1) ◽  
pp. R201-R207 ◽  
Author(s):  
R. S. Mazzeo ◽  
G. A. Brooks ◽  
G. E. Butterfield ◽  
D. A. Podolin ◽  
E. E. Wolfel ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Sympathetic Activity ◽  
Chronic Exposure ◽  
Submaximal Exercise ◽  
Control Group ◽  
Beta Blockade ◽  
Plasma Norepinephrine ◽  
Altitude Exposure ◽  
Acute And Chronic Exposure

This investigation examined the relationship between alterations in plasma norepinephrine associated with 21 days of high-altitude exposure and muscle sympathetic activity both at rest and during exercise. Healthy sea level residents, divided into a control group (n = 5) receiving a placebo or a drug group (n = 6) receiving 240 mg/day of propranolol, were studied while at sea level, upon arrival (acute), and after 21 days of residence (chronic) at 4,300 m. Arterial norepinephrine levels and net leg uptake and release of norepinephrine were determine both at rest and during 45 min of submaximal exercise via samples collected from femoral arterial and venous catheters. Arterial norepinephrine levels increased significantly after chronic altitude exposure both at rest (84%) and during exercise (174%) compared with sea level and acute values. A net uptake of norepinephrine was found in resting legs at sea level (0.28 +/- 0.05 nmol/min) and with acute exposure (0.07 +/- 0.06 nmol/min); however, a significant switch to net leg norepinephrine release was observed with chronic altitude exposure (0.51 +/- 0.11 nmol/min). With exercise, a net release of norepinephrine by the leg occurred across all conditions with chronic exposure, again eliciting the greatest values (5.3 +/- 0.6, 8.0 +/- 1.7, and 14.4 +/- 3.1 nmol/min for sea level, acute, and chronic exposure, respectively). It was concluded that muscle sympathetic activity is significantly elevated both at rest and during submaximal exercise as a result of chronic high-altitude exposure, and muscle is a major contributor to the increase in plasma norepinephrine levels associated with prolonged altitude exposure. The presence of dense beta-blockade did not alter this adaptation to altitude.

CATECHOLAMINE RESPONSE AT REST AND DURING EXERCISE AT SEA LEVEL, ACUTE AND CHRONIC EXPOSURE TO HIGH ALTITUDE.

1980 ◽  
Vol 21 (Supplement) ◽  
pp. S61
Author(s):  
R. S. Mazzeo ◽  
G. A. Brooks ◽  
J. Sutton ◽  
G. Butterfield ◽  
G. Wolfel ◽  
...  
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Chronic Exposure ◽  
Catecholamine Response ◽  
Acute And Chronic Exposure

Modulation of Immune Response by the Acute and Chronic Exposure to High Altitude

2005 ◽  
Vol 37 (5) ◽  
pp. 768-774 ◽  
Author(s):  
MONICA FACCO ◽  
CHIARA ZILLI ◽  
MARTA SIVIERO ◽  
ANDREA ERMOLAO ◽  
GIUSEPPE TRAVAIN ◽  
...  
Keyword(s):  
Immune Response ◽  
High Altitude ◽  
Chronic Exposure ◽  
Acute And Chronic Exposure

713 DOES ERYTHROCYTE REINFUSION IMPROVE TWO-MILE RUN PERFORMANCE DURING ACUTE AND CHRONIC EXPOSURE TO HIGH ALTITUDE (4300m)?

1994 ◽  
Vol 26 (Supplement) ◽  
pp. S127 ◽  
Author(s):  
K. B. Pandolf ◽  
A. J. Young ◽  
M. W. Sharp ◽  
J. L. Kenncy ◽  
R. R. Cote ◽  
...  
Keyword(s):  
High Altitude ◽  
Chronic Exposure ◽  
Acute And Chronic Exposure
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