scholarly journals Competing Mechanisms of Stress-Assisted Diffusivity and Stretch-Activated Currents in Cardiac Electromechanics

2018 ◽  
Vol 9 ◽  
Author(s):  
Alessandro Loppini ◽  
Alessio Gizzi ◽  
Ricardo Ruiz-Baier ◽  
Christian Cherubini ◽  
Flavio H. Fenton ◽  
...  
Keyword(s):  
Cardiac Electromechanics

Scaffold topography alters intracellular calcium dynamics in cultured cardiomyocyte networks

2004 ◽  
Vol 287 (3) ◽  
pp. H1276-H1285 ◽  
Author(s):  
Lihong Yin ◽  
Harold Bien ◽  
Emilia Entcheva
Keyword(s):  
Ventricular Myocytes ◽  
Three Dimensional ◽  
Triggered Release ◽  
In Vitro System ◽  
Functional Changes ◽  
Cardiac Electromechanics ◽  
Intracellular Ca ◽  
Intracellular Calcium Dynamics ◽  
Cell Networks

Structural and functional changes ensue in cardiac cell networks when cells are guided by three-dimensional scaffold topography. We report enhanced synchronous pacemaking activity in association with slow diastolic rise in intracellular Ca2+ concentration ([Ca2+]i) in cell networks grown on microgrooved scaffolds. Topography-driven changes in cardiac electromechanics were characterized by the frequency dependence of [Ca2+]i in syncytial structures formed of ventricular myocytes cultured on microgrooved elastic scaffolds (G). Cells were electrically paced at 0.5–5 Hz, and [Ca2+]i was determined using microscale ratiometric (fura 2) fluorescence. Compared with flat (F) controls, the G networks exhibited elevated diastolic [Ca2+]i at higher frequencies, increased systolic [Ca2+]i across the entire frequency range, and steeper restitution of Ca2+ transient half-width ( n = 15 and 7 for G and F, respectively, P < 0.02). Significant differences in the frequency response of force-related parameters were also found, e.g., overall larger total area under the Ca2+ transients and faster adaptation of relaxation time to pacing rate ( P < 0.02). Altered [Ca2+]i dynamics were paralleled by higher occurrence of spontaneous Ca2+ release and increased sarcoplasmic reticulum load ( P < 0.02), indirectly assessed by caffeine-triggered release. Electromechanical instabilities, i.e., Ca2+ and voltage alternans, were more often observed in G samples. Taken together, these findings 1) represent some of the first functional electromechanical data for this in vitro system and 2) demonstrate direct influence of the microstructure on cardiac function and susceptibility to arrhythmias via Ca2+-dependent mechanisms. Overall, our results substantiate the idea of guiding cellular phenotype by cellular microenvironment, e.g., scaffold design in the context of tissue engineering.

scholarly journals Mathematical analysis of cardiac electromechanics with physiological ionic model

2017 ◽  
Vol 22 (11) ◽  
pp. 1-35
Author(s):  
Mostafa Bendahmane ◽  
◽  
Fatima Mroue ◽  
Mazen Saad ◽  
Raafat Talhouk ◽  
...  
Keyword(s):  
Mathematical Analysis ◽  
Ionic Model ◽  
Cardiac Electromechanics

scholarly journals Models of cardiac electromechanics based on individual hearts imaging data

2010 ◽  
Vol 10 (3) ◽  
pp. 295-306 ◽  
Author(s):  
Viatcheslav Gurev ◽  
Ted Lee ◽  
Jason Constantino ◽  
Hermenegild Arevalo ◽  
Natalia A. Trayanova
Keyword(s):  
Imaging Data ◽  
Cardiac Electromechanics

Ventricular-vascular coupling in numerical models of cardiac electromechanics

2006 ◽  
Vol 39 ◽  
pp. S286
Author(s):  
R. Kerckhoffs ◽  
Q. Gu ◽  
J. Omens ◽  
A. McCulloch
Keyword(s):  
Numerical Models ◽  
Cardiac Electromechanics

Computational model of three-dimensional cardiac electromechanics

2002 ◽  
Vol 4 (4) ◽  
pp. 249-257 ◽  
Author(s):  
Taras P. Usyk ◽  
Ian J. LeGrice ◽  
Andrew D. McCulloch
Keyword(s):  
Computational Model ◽  
Three Dimensional ◽  
Cardiac Electromechanics

Towards integrated noninvasive personalization of cardiac electromechanics

2012 ◽  
Author(s):  
Hongda Mao ◽  
Linwei Wang ◽  
Ken C. L. Wong ◽  
Huafeng Liu ◽  
Pengcheng Shi
Keyword(s):  
Cardiac Electromechanics

scholarly journals Optical Mapping of Cardiac Electromechanics

2016 ◽  
Vol 111 (2) ◽  
pp. 269-270 ◽  
Author(s):  
Matthew W. Kay ◽  
Igor R. Efimov
Keyword(s):  
Optical Mapping ◽  
Cardiac Electromechanics

scholarly journals Erratum to: Models of cardiac electromechanics based on individual hearts imaging data

2011 ◽  
Vol 10 (3) ◽  
pp. 307-307 ◽  
Author(s):  
Viatcheslav Gurev ◽  
Ted Lee ◽  
Jason Constantino ◽  
Hermenegild Arevalo ◽  
Natalia A. Trayanova
Keyword(s):  
Imaging Data ◽  
Cardiac Electromechanics
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