scholarly journals Editorial: Ion Channel Trafficking and Cardiac Arrhythmias

2018 ◽  
Vol 9 ◽  
Author(s):  
Marcel A. G. van der Heyden ◽  
Brian P. Delisle ◽  
Hugues Abriel
Keyword(s):  
Ion Channel ◽  
Cardiac Arrhythmias ◽  
Channel Trafficking ◽  
Ion Channel Trafficking

scholarly journals Remodeling of Ion Channel Trafficking and Cardiac Arrhythmias

Cells ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 2417
Author(s):  
Camille E. Blandin ◽  
Basile J. Gravez ◽  
Stéphane N. Hatem ◽  
Elise Balse
Keyword(s):  
Plasma Membrane ◽  
Ion Channels ◽  
Ion Channel ◽  
Cardiac Arrhythmias ◽  
Common Factors ◽  
Functional Expression ◽  
Cellular Level ◽  
Channel Trafficking ◽  
Genes Encoding ◽  
Ion Channel Trafficking

Both inherited and acquired cardiac arrhythmias are often associated with the abnormal functional expression of ion channels at the cellular level. The complex machinery that continuously traffics, anchors, organizes, and recycles ion channels at the plasma membrane of a cardiomyocyte appears to be a major source of channel dysfunction during cardiac arrhythmias. This has been well established with the discovery of mutations in the genes encoding several ion channels and ion channel partners during inherited cardiac arrhythmias. Fibrosis, altered myocyte contacts, and post-transcriptional protein changes are common factors that disorganize normal channel trafficking during acquired cardiac arrhythmias. Channel availability, described notably for hERG and KV1.5 channels, could be another potent arrhythmogenic mechanism. From this molecular knowledge on cardiac arrhythmias will emerge novel antiarrhythmic strategies.

scholarly journals Non-conventional Axonal Organelles Control TRPM8 Ion Channel Trafficking and Peripheral Cold Sensing

Cell Reports ◽  
2020 ◽  
Vol 30 (13) ◽  
pp. 4505-4517.e5 ◽  
Author(s):  
Víctor Hugo Cornejo ◽  
Carolina González ◽  
Matías Campos ◽  
Leslie Vargas-Saturno ◽  
María de los Ángeles Juricic ◽  
...  
Keyword(s):  
Ion Channel ◽  
Channel Trafficking ◽  
Ion Channel Trafficking ◽  
Cold Sensing

scholarly journals Physical and functional interaction of KV 10.1 with Rabaptin-5 impacts ion channel trafficking

FEBS Letters ◽  
2012 ◽  
Vol 586 (19) ◽  
pp. 3077-3084 ◽  
Author(s):  
Milena Ninkovic ◽  
Mišo Mitkovski ◽  
Tobias Kohl ◽  
Walter Stühmer ◽  
Luis A. Pardo
Keyword(s):  
Ion Channel ◽  
Functional Interaction ◽  
Channel Trafficking ◽  
Ion Channel Trafficking
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