scholarly journals How to Construct, Conduct and Analyze an Exercise Training Study?

2018 ◽  
Vol 9 ◽  
Author(s):  
Anne Hecksteden ◽  
Oliver Faude ◽  
Tim Meyer ◽  
Lars Donath
2019 ◽  
Vol 105 (3) ◽  
pp. 660-676 ◽  
Author(s):  
Robert M Edinburgh ◽  
Helen E Bradley ◽  
Nurul-Fadhilah Abdullah ◽  
Scott L Robinson ◽  
Oliver J Chrzanowski-Smith ◽  
...  

Abstract Context Pre-exercise nutrient availability alters acute metabolic responses to exercise, which could modulate training responsiveness. Objective To assess acute and chronic effects of exercise performed before versus after nutrient ingestion on whole-body and intramuscular lipid utilization and postprandial glucose metabolism. Design (1) Acute, randomized, crossover design (Acute Study); (2) 6-week, randomized, controlled design (Training Study). Setting General community. Participants Men with overweight/obesity (mean ± standard deviation, body mass index: 30.2 ± 3.5 kg⋅m-2 for Acute Study, 30.9 ± 4.5 kg⋅m-2 for Training Study). Interventions Moderate-intensity cycling performed before versus after mixed-macronutrient breakfast (Acute Study) or carbohydrate (Training Study) ingestion. Results Acute Study—exercise before versus after breakfast consumption increased net intramuscular lipid utilization in type I (net change: –3.44 ± 2.63% versus 1.44 ± 4.18% area lipid staining, P < 0.01) and type II fibers (–1.89 ± 2.48% versus 1.83 ± 1.92% area lipid staining, P < 0.05). Training Study—postprandial glycemia was not differentially affected by 6 weeks of exercise training performed before versus after carbohydrate intake (P > 0.05). However, postprandial insulinemia was reduced with exercise training performed before but not after carbohydrate ingestion (P = 0.03). This resulted in increased oral glucose insulin sensitivity (25 ± 38 vs –21 ± 32 mL⋅min-1⋅m-2; P = 0.01), associated with increased lipid utilization during exercise (r = 0.50, P = 0.02). Regular exercise before nutrient provision also augmented remodeling of skeletal muscle phospholipids and protein content of the glucose transport protein GLUT4 (P < 0.05). Conclusions Experiments investigating exercise training and metabolic health should consider nutrient-exercise timing, and exercise performed before versus after nutrient intake (ie, in the fasted state) may exert beneficial effects on lipid utilization and reduce postprandial insulinemia.


2013 ◽  
Vol 27 (S1) ◽  
Author(s):  
Lasse Gliemann ◽  
Michael Nyberg ◽  
Rasmus S Biensø ◽  
Ninna Iversen ◽  
Jesper Olesen ◽  
...  

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