scholarly journals ADM Scaffolds Generate a Pro-regenerative Microenvironment During Full-Thickness Cutaneous Wound Healing Through M2 Macrophage Polarization via Lamtor1

2018 ◽  
Vol 9 ◽  
Author(s):  
Chengmin He ◽  
Zhi Yang ◽  
Ying Jin ◽  
Xiaoyang Qi ◽  
Jin Chu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
M2 Macrophage Polarization

Study on the Effect of Cerium Oxide Nanocubes on Full-Thickness Cutaneous Wound Healing of Type 2 Diabetic Rats

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 643-P ◽  
Author(s):  
YANFEI HAN ◽  
LINDONG LI ◽  
YANJUN LIU ◽  
YOU WANG ◽  
CHUNHUA YAN ◽  
...  
Keyword(s):  
Wound Healing ◽  
Cerium Oxide ◽  
Diabetic Rats ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound ◽  
Type 2 Diabetic

scholarly journals The Effect of 17β-Estradiol Administration on Cutaneous Wound Healing in 24-Week Ovariectomized Female Mice

2014 ◽  
Vol 2014 ◽  
pp. 1-8 ◽  
Author(s):  
Kanae Mukai ◽  
Yukari Nakajima ◽  
Tamae Urai ◽  
Emi Komatsu ◽  
Kana Takata ◽  
...  
Keyword(s):  
Wound Healing ◽  
Inflammatory Response ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Estrogen Replacement ◽  
Wound Area ◽  
Cutaneous Wound ◽  
Female Mice ◽  
Exogenous Estrogen ◽  
17Β Estradiol

Estrogen replacement promotes cutaneous wound healing in 8–10-week young ovariectomized female mice. However, research using aged ovariectomized female mice has not been reported, to the best of our knowledge. Therefore, we investigated the effect of 17β-estradiol on cutaneous wound healing using 24-week middle-aged ovariectomized female mice. Twenty-week-old female mice were divided into three groups: medication with 17β-estradiol after ovariectomy (OVX + 17β-estradiol), ovariectomy (OVX), and sham (SHAM). After 4 weeks, the mice received two full-thickness wounds. Then, the OVX + 17β-estradiol group was administered 17β-estradiol at 0.01 g/day until healing. The ratio of wound area in the OVX + 17β-estradiol group was significantly decreased compared with that in the OVX group. The numbers of neutrophils and macrophages in the OVX + 17β-estradiol group were significantly smaller than those in the OVX group. In addition, the ratio of myofibroblasts in the OVX + 17β-estradiol group was significantly higher than that in the OVX group. These data suggested that exogenous continuous 17β-estradiol administration promotes cutaneous wound healing in 24-week OVX female mice by reducing wound area, shortening inflammatory response, and promoting wound contraction. However, it is unclear whether the effect of exogenous estrogen on wound healing outweighs the delay of wound healing due to advanced age.

scholarly journals MSC-Derived Exosome Promotes M2 Polarization and Enhances Cutaneous Wound Healing

2019 ◽  
Vol 2019 ◽  
pp. 1-16 ◽  
Author(s):  
Xiaoning He ◽  
Zhiwei Dong ◽  
Yina Cao ◽  
Han Wang ◽  
Shiyu Liu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Wound Healing ◽  
Wound Repair ◽  
Macrophage Polarization ◽  
Therapeutic Effects ◽  
Cutaneous Wound Healing ◽  
Bone Marrow Mscs ◽  
Wound Site ◽  
Cutaneous Wound ◽  
M2 Polarization

Mesenchymal stem cell transplantation (MSCT) promotes cutaneous wound healing. Numerous studies have shown that the therapeutic effects of MSCT appear to be mediated by paracrine signaling. However, the cell-cell interaction during MSCT between MSCs and macrophages in the region of cutaneous wound healing is still unknown. In this study, early depletion of macrophages delayed the wound repair with MSC injection, which suggested that MSC-mediated wound healing required macrophages. Moreover, we demonstrated that systemically infused bone marrow MSCs (BMMSCs) and jaw bone marrow MSCs (JMMSCs) could translocate to the wound site, promote macrophages toward M2 polarization, and enhance wound healing.In vitrococulture of MSCs with macrophages enhanced their M2 polarization. Mechanistically, we found that exosomes derived from MSCs induced macrophage polarization and depletion of exosomes of MSCs reduced the M2 phenotype of macrophages. Infusing MSCs without exosomes led to lower number of M2 macrophages at the wound site along with delayed wound repair. We further showed that the miR-223, derived from exosomes of MSCs, regulated macrophage polarization by targeting pknox1. These findings provided the evidence that MSCT elicits M2 polarization of macrophages and may accelerate wound healing by transferring exosome-derived microRNA.

Cutaneous wound healing in the EpiDerm-FT full thickness in vitro human skin model

2010 ◽  
Vol 196 ◽  
pp. S152
Author(s):  
S. Letasiova ◽  
P. Hayden ◽  
G. Stolper ◽  
A. Armento ◽  
C. Cooney ◽  
...  
Keyword(s):  
Wound Healing ◽  
Human Skin ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Skin Model ◽  
Cutaneous Wound

scholarly journals AGEs Induced Autophagy Impairs Cutaneous Wound Healing via Stimulating Macrophage Polarization to M1 in Diabetes

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Yuanyuan Guo ◽  
Cai Lin ◽  
Peng Xu ◽  
Shan Wu ◽  
Xiujun Fu ◽  
...  
Keyword(s):  
Wound Healing ◽  
Macrophage Polarization ◽  
Cutaneous Wound Healing ◽  
Cutaneous Wound

The effect of adipose tissue derived MSCs delivered by a chemically defined carrier on full-thickness cutaneous wound healing

Biomaterials ◽  
2013 ◽  
Vol 34 (10) ◽  
pp. 2501-2515 ◽  
Author(s):  
Dongsheng Jiang ◽  
Yu Qi ◽  
Nathan G. Walker ◽  
Anca Sindrilaru ◽  
Adelheid Hainzl ◽  
...  
Keyword(s):  
Wound Healing ◽  
Adipose Tissue ◽  
Cutaneous Wound Healing ◽  
Full Thickness ◽  
Cutaneous Wound

IL-33 improves wound healing through enhanced M2 macrophage polarization in diabetic mice

2017 ◽  
Vol 90 ◽  
pp. 42-49 ◽  
Author(s):  
Rongguo He ◽  
Hui Yin ◽  
Baohong Yuan ◽  
Tao Liu ◽  
Li Luo ◽  
...  
Keyword(s):  
Wound Healing ◽  
Macrophage Polarization ◽  
M2 Macrophage ◽  
Diabetic Mice ◽  
M2 Macrophage Polarization
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