scholarly journals The Role of Macrophages in Acute and Chronic Wound Healing and Interventions to Promote Pro-wound Healing Phenotypes

2018 ◽  
Vol 9 ◽  
Author(s):  
Paulina Krzyszczyk ◽  
Rene Schloss ◽  
Andre Palmer ◽  
François Berthiaume
Keyword(s):  
Wound Healing ◽  
Chronic Wound

scholarly journals Role of whole bone marrow, whole bone marrow cultured cells, and mesenchymal stem cells in chronic wound healing

2015 ◽  
Vol 6 (1) ◽  
Author(s):  
Luis Rodriguez-Menocal ◽  
Shahjahan Shareef ◽  
Marcela Salgado ◽  
Arsalan Shabbir ◽  
Evangelos Van Badiavas
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Chronic Wound ◽  
Cultured Cells

scholarly journals Role of angiogenesis and angiogenic factors in acute and chronic wound healing

2015 ◽  
Vol 2 (5) ◽  
pp. 243 ◽  
Author(s):  
Pramod Kumar ◽  
Sudesh Kumar ◽  
EchalasaraGovindarama Padmanabha Udupa ◽  
Udaya Kumar ◽  
Pragna Rao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Angiogenic Factors

Understanding the Potential Role and Delivery Approaches of Nitric Oxide in the Chronic Wound Healing Management

2020 ◽  
Vol 26 ◽  
Author(s):  
Mimansa Kandhwal ◽  
Tapan Behl ◽  
Arun Kumar ◽  
Sandeep Arora
Keyword(s):  
Nitric Oxide ◽  
Wound Healing ◽  
Chronic Wound ◽  
Lower Limbs ◽  
Diabetic Patients ◽  
Pharmacological Mechanism ◽  
Novel Treatments ◽  
Beneficial Effects ◽  
Chronic Ulcers

: Nitric oxide (NO) is a promising pharmaceutical component that has vasodilator, antibacterial and wound healing activity. Chronic ulcers are non-healing disorders that are generally associated with distortion of lower limbs. Among the severe consequence’s derivative of these diseases, are the problems of chronic wound progression. NO which is categorized as smallest gaseous neurotransmitter has beneficial effects in different phases of chronic inflammation. Defensive mechanism of NO is found useful in several severe conditions such as gestational healing, gastrointestinal healing and diabetic healing. The current review presents up to date collection of literature about role of NO in chronic ulcers due to the prevalence of diabetes, DPN, and diabetic foot ulcers, and because of the lack of available effective treatments to directly address the pathology contributing to these conditions, novel treatments are being sought. This review also collects the information about deficiency of NO synthase in diabetic patients leads to a lack of vascularization of the peripheral nerves, which causes diabetic neuropathy; and this could be treated with vasodilators such as nitric oxide. Apart from pharmacological mechanism of NO, the article also reviewed and analyzed to elucidate the potential of a transdermal delivery of NO for the treatment of chronic ulcers.

Challenges with Wound Infection Models in Drug Development

2020 ◽  
Vol 21 (13) ◽  
pp. 1301-1312 ◽  
Author(s):  
Sandeep K. Shukla ◽  
Ajay K. Sharma ◽  
Vanya Gupta ◽  
Aman Kalonia ◽  
Priyanka Shaw
Keyword(s):  
Wound Healing ◽  
Wound Infection ◽  
Chronic Wound ◽  
Wound Care ◽  
Infection Model ◽  
In Vivo Models ◽  
Infection Models

: Wound research is an evolving science trying to unfold the complex untold mechanisms behind the wound healing cascade. In particular, interest is growing regarding the role of microorganisms in both acute and chronic wound healing. Microbial burden plays an important role in the persistence of chronic wounds, ultimately resulting in delayed wound healing. It is therefore important for clinicians to understand the evolution of infection science and its various etiologies. Therefore, to understand the role of bacterial biofilm in chronic wound pathogenesis, various in vitro and in vivo models are required to investigate biofilms in wound-like settings. Infection models should be refined comprising an important signet of biofilms. These models are eminent for translational research to obtain data for designing an improved wound care formulation. However, all the existing models possess limitations and do not fit properly in the model frame for developing wound care agents. Among various impediments, one of the major drawbacks of such models is that the wound they possess does not mimic the wound a human develops. Therefore, a novel wound infection model is required which can imitate the human wounds. : This review article mainly discusses various in vitro and in vivo models showing microbial colonization, their advantages and challenges. Apart from these models, there are also present ex vivo wound infection models, but this review mainly focused on various in vitro and in vivo models available for studying wound infection in controlled conditions. This information might be useful in designing an ideal wound infection model for developing an effective wound healing formulation.

Anti‐inflammatory effects of haptoglobin on LPS ‐stimulated macrophages: Role of HMGB1 signaling and implications in chronic wound healing

2020 ◽  
Vol 28 (4) ◽  
pp. 493-505
Author(s):  
Paulina Krzyszczyk ◽  
Hwan June Kang ◽  
Suneel Kumar ◽  
Yixin Meng ◽  
Maurice D. O'Reggio ◽  
...  
Keyword(s):  
Wound Healing ◽  
Chronic Wound ◽  
Anti Inflammatory

Role of Vitamin C in Chronic Wound Healing

Vitamin C ◽  
2020 ◽  
pp. 161-179
Author(s):  
Juliet M. Pullar ◽  
Margreet C.M. Vissers
Keyword(s):  
Wound Healing ◽  
Vitamin C ◽  
Chronic Wound

scholarly journals The Wound Microbiome: Modern Approaches to Examining the Role of Microorganisms in Impaired Chronic Wound Healing

2014 ◽  
Vol 3 (7) ◽  
pp. 502-510 ◽  
Author(s):  
Ana M. Misic ◽  
Sue E. Gardner ◽  
Elizabeth A. Grice
Keyword(s):  
Wound Healing ◽  
Chronic Wound

An Update on Chronic Wounds and The Role of Biofilms

2013 ◽  
Vol 17 (6) ◽  
pp. 371-376 ◽  
Author(s):  
Christina Scali ◽  
Brian Kunimoto
Keyword(s):  
Wound Healing ◽  
Chronic Wounds ◽  
Chronic Wound ◽  
Combined Treatment ◽  
Chronic Infections ◽  
Healing Environment ◽  
Aggressive Debridement ◽  
Antibiofilm Agents ◽  
Major Impediment

Background: Chronic wounds cause significant morbidity and mortality and cost our health care system millions of dollars each year. A major impediment to wound healing is the formation of bacterial biofilms. Biofilms are communities of bacteria associated with chronic infections. Objective: This article reviews the literature on chronic wounds and biofilms. The role of biofilms in chronic wounds is not widely known. The purpose is to increase awareness of their role and to discuss research into novel therapeutic options. Methods: PubMed searches were performed to identify publications on chronic wounds and biofilms. Results: Biofilms contribute to chronic wound nonhealing. There is an abundance of research into novel antibiofilm strategies for chronic wounds. Conclusion: Current research is being targeted at antibiofilm strategies needed to restore an optimal wound-healing environment. A combined treatment approach involving aggressive débridement and the addition of antibiofilm agents is needed.

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