scholarly journals The Molecular Basis for Altered Cation Permeability in Hereditary Stomatocytic Human Red Blood Cells

2018 ◽  
Vol 9 ◽  
Author(s):  
Joanna F. Flatt ◽  
Lesley J. Bruce
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Molecular Basis ◽  
Human Red Blood Cells ◽  
Cation Permeability

Voltage-activated cation permeability in high-potassium but not low-potassium red blood cells

1990 ◽  
Vol 258 (6) ◽  
pp. C1169-C1172 ◽  
Author(s):  
J. A. Halperin ◽  
C. Brugnara ◽  
T. Van Ha ◽  
D. C. Tosteson
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Dielectric Breakdown ◽  
Cation Transport ◽  
Membrane Component ◽  
Transport Pathway ◽  
High Potassium ◽  
Human Red Blood Cells ◽  
Cation Permeability ◽  
Low Potassium

We have recently reported that voltage-activated fluxes of Na, K, and Ca occur in human red blood cells [J.A. Halperin, C. Brugnara, M. Tosteson, T. Van Ha, and D. C. Tosteson. Am. J. Physiol. 257 (Cell Physiol. 26): C986-C996, 1989]. The cation permeability increases progressively as the membrane potential becomes more inside positive above +20 mV. In this paper we show that this effect also occurs in high-potassium (HK), but not in low-potassium (LK), sheep and dog red blood cells. This result suggests that the voltage-activated cation transport pathway is not the result of nonspecific dielectric breakdown of the lipid bilayer but, rather, relates to some membrane component, presumably a protein, that is expressed in HK human and sheep but not in LK sheep and dog red blood cells.

Calcium, cell shrinkage, and prolytic state of human red blood cells

1987 ◽  
Vol 252 (2) ◽  
pp. C138-C152 ◽  
Author(s):  
L. M. Crespo ◽  
T. S. Novak ◽  
J. C. Freedman
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Major Effect ◽  
Ionophore A23187 ◽  
Cell Shrinkage ◽  
Human Red Blood Cells ◽  
Na Permeability ◽  
Cation Permeability ◽  
High K ◽  
Indirect Consequence

The effects of intracellular calcium, or Cac, on the Na permeability of human red blood cells were examined during 3-h incubations with the Ca ionophore A23187 and varied external Ca, Cao. Above 3 microM Cao, Nac increased significantly as ATP decreased. Maintenance of normal ATP with vanadate did not prevent the gain of Nac. Similar amounts of Nac were gained in 3 h by ouabain-treated cells exposed to the K ionophore valinomycin or by cells osmotically shrunken. Cells shrunken with sucrose also exhibited partial loss of Kc. When the cells with increased Nac were subsequently transferred to Na-free, high-K medium, the Nac and Kc that had changed slowly over 3 h returned toward normal within 10 min. The development of irreversible high cation permeability in shrunken cells was not prevented by a variety of transport inhibitors. These observations and cell volume distributions suggest that prolonged shrinkage induces a subpopulation of cells to become highly cation permeable, or "prolytic". The major effect of Cac on Na permeability appears to be an indirect consequence of cell shrinkage due to KCl loss.

scholarly journals Transbilayer distribution and mobility of phosphatidylinositol in human red blood cells.

1990 ◽  
Vol 265 (27) ◽  
pp. 16035-16038 ◽  
Author(s):  
P Bütikofer ◽  
Z W Lin ◽  
D T Chiu ◽  
B Lubin ◽  
F A Kuypers
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Human Red Blood Cells
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