scholarly journals On the Effects of Reactive Oxygen Species and Nitric Oxide on Red Blood Cell Deformability

2018 ◽  
Vol 9 ◽  
Author(s):  
Lukas Diederich ◽  
Tatsiana Suvorava ◽  
Roberto Sansone ◽  
T. C. Stevenson Keller ◽  
Frederik Barbarino ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Effects of nitric oxide and its congeners on sickle red blood cell deformability

Transfusion ◽  
2015 ◽  
Vol 55 (10) ◽  
pp. 2464-2472 ◽  
Author(s):  
Andrea M. Belanger ◽  
Christian Keggi ◽  
Tamir Kanias ◽  
Mark T. Gladwin ◽  
Daniel B. Kim-Shapiro
Keyword(s):  
Nitric Oxide ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

Uremic Toxicity-Induced Eryptosis and Monocyte Modulation: The Erythrophagocytosis as a Novel Pathway to Renal Anemia

2016 ◽  
Vol 41 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Natalia Borges Bonan ◽  
Thiago M. Steiner ◽  
Viktoriya Kuntsevich ◽  
Grazia Maria Virzì ◽  
Marina Azevedo ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Reactive Oxygen ◽  
Renal Anemia ◽  
Healthy Controls ◽  
Oxygen Species

Background: We tested the effect of uremia on red blood cell (RBC) eryptosis, CD14++/CD16+ monocytes and erythrophagocytosis. Design: RBC and monocytes from chronic kidney disease (CKD) stages 3/4 (P-CKD3/4) or hemodialysis (HD) patients and healthy controls (HCs) cells incubated with sera pools from patients with CKD stages 2/3 (S-CKD2/3) or 4/5 (S-CKD4/5) were evaluated to assess eryptosis, monocyte phenotypes and reactive oxygen species (ROS) by cytometer. Erythrophagocytosis was evaluated by subsequent co-incubation of preincubated HC-monocytes and autologous-RBC. Results: HC-eryptosis (1.3 ± 0.9%) was lower than in HD (4.3 ± 0.5%) and HC-RBC incubated with S-CKD4/5 (5.6 ± 1%). CD14++/CD16+ were augmented in P-CKD3/4 (34.6 ± 8%) and HC-monocytes incubated with S-CKD4/5 (26.4 ± 7%) than in HC (5.4 ± 1%). In these cells, ROS was increased (44.5 ± 9%; control 9.6 ± 2%) and inhibited by N-acetylcysteine (25 ± 13%). Erythrophagocytosis was increased in CD14++/CD16+ (60.8 ± 10%) than in CD14++/CD16- (15.5 ± 2%). Conclusions: Sera pools from CKD patients increase eryptosis and promote a proinflammatory monocyte phenotype. Both processes increased erythrophagocytosis, thereby suggesting a novel pathway for renal anemia.

P038. The role of nitric oxide in regulation of red blood cell deformability

Nitric Oxide ◽  
2006 ◽  
Vol 14 (4) ◽  
pp. 30
Author(s):  
Xiaojun He ◽  
Ivan Azarov ◽  
Daniel B. Kim-Shapiro
Keyword(s):  
Nitric Oxide ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability

scholarly journals Ligation of Glycophorin A Generates Reactive Oxygen Species Leading to Decreased Red Blood Cell Function

PLoS ONE ◽  
2016 ◽  
Vol 11 (1) ◽  
pp. e0141206 ◽  
Author(s):  
Joseph Khoory ◽  
Jessica Estanislau ◽  
Abdallah Elkhal ◽  
Asmae Lazaar ◽  
Mark I. Melhorn ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Function ◽  
Reactive Oxygen ◽  
Glycophorin A ◽  
Oxygen Species

scholarly journals Regulation of red blood cell deformability is independent of red blood cell-nitric oxide synthase under hypoxia

2016 ◽  
Vol 63 (3) ◽  
pp. 199-215 ◽  
Author(s):  
Marijke Grau ◽  
Alexander Lauten ◽  
Steffen Hoeppener ◽  
Bjoern Goebel ◽  
Julian Brenig ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Blood Cell ◽  
Red Blood Cell ◽  
Cell Deformability ◽  
Red Blood Cell Deformability ◽  
Oxide Synthase
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