scholarly journals Mechanistic Role of Reactive Oxygen Species and Therapeutic Potential of Antioxidants in Denervation- or Fasting-Induced Skeletal Muscle Atrophy

2018 ◽  
Vol 9 ◽  
Author(s):  
Jiaying Qiu ◽  
Qingqing Fang ◽  
Tongtong Xu ◽  
Changyue Wu ◽  
Lai Xu ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Therapeutic Potential ◽  
Reactive Oxygen ◽  
Skeletal Muscle Atrophy ◽  
Oxygen Species

Transforming growth factor type beta (TGF-β) requires reactive oxygen species to induce skeletal muscle atrophy

2016 ◽  
Vol 28 (5) ◽  
pp. 366-376 ◽  
Author(s):  
Johanna Abrigo ◽  
Juan Carlos Rivera ◽  
Felipe Simon ◽  
Daniel Cabrera ◽  
Claudio Cabello-Verrugio
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Growth Factor ◽  
Muscle Atrophy ◽  
Transforming Growth Factor ◽  
Reactive Oxygen ◽  
Skeletal Muscle Atrophy ◽  
Oxygen Species ◽  
Factor Type

scholarly journals Role of reactive oxygen species in contraction-mediated glucose transport in mouse skeletal muscle

2006 ◽  
Vol 575 (1) ◽  
pp. 251-262 ◽  
Author(s):  
Marie E. Sandström ◽  
Shi-Jin Zhang ◽  
Joseph Bruton ◽  
José P. Silva ◽  
Michael B. Reid ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Glucose Transport ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Mouse Skeletal Muscle

Age and sex differences in human skeletal muscle: Role of reactive oxygen species

2000 ◽  
Vol 33 (3) ◽  
pp. 287-293 ◽  
Author(s):  
O. Pansarasa ◽  
L. Castagna ◽  
B. Colombi ◽  
J. Vecchiet ◽  
G. Felzani ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Sex Differences ◽  
Human Skeletal Muscle ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Age And Sex

scholarly journals Mitochondrial Permeability Transition Causes Mitochondrial Reactive Oxygen Species- and Caspase 3-Dependent Atrophy of Single Adult Mouse Skeletal Muscle Fibers

Cells ◽  
2021 ◽  
Vol 10 (10) ◽  
pp. 2586
Author(s):  
Sarah K. Burke ◽  
Angelo Solania ◽  
Dennis W. Wolan ◽  
Michael S. Cohen ◽  
Terence E. Ryan ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Skeletal Muscle ◽  
Muscle Atrophy ◽  
Caspase 3 ◽  
Mitochondrial Permeability Transition ◽  
Permeability Transition ◽  
Skeletal Muscle Atrophy ◽  
Oxygen Species ◽  
Mitochondrial Reactive Oxygen Species ◽  
Mitochondrial Permeability

Elevated mitochondrial reactive oxygen species (mROS) and an increase in caspase-3 activity are established mechanisms that lead to skeletal muscle atrophy via the upregulation of protein degradation pathways. However, the mechanisms upstream of an increase in mROS and caspase-3 activity in conditions of muscle atrophy have not been identified. Based upon knowledge that an event known as mitochondrial permeability transition (MPT) causes an increase in mROS emission and the activation of caspase-3 via mitochondrial release of cytochrome c, as well as the circumstantial evidence for MPT in some muscle atrophy conditions, we tested MPT as a mechanism of atrophy. Briefly, treating cultured single mouse flexor digitorum brevis (FDB) fibers from adult mice with a chemical inducer of MPT (Bz423) for 24 h caused an increase in mROS and caspase-3 activity that was accompanied by a reduction in muscle fiber diameter that was able to be prevented by inhibitors of MPT, mROS, or caspase-3 (p < 0.05). Similarly, a four-day single fiber culture as a model of disuse caused atrophy that could be prevented by inhibitors of MPT, mROS, or activated caspase-3. As such, our results identify MPT as a novel mechanism of skeletal muscle atrophy that operates through mROS emission and caspase-3 activation.

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