scholarly journals Multifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. I. Multifractal Analysis of Clinical Data

2018 ◽  
Vol 8 ◽  
Author(s):  
Guillaume Attuel ◽  
Evgeniya Gerasimova-Chechkina ◽  
Francoise Argoul ◽  
Hussein Yahia ◽  
Alain Arneodo
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Data ◽  
Multifractal Analysis ◽  
Excitable Cell ◽  
Cell Network

scholarly journals Multifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. II. Modeling

2019 ◽  
Vol 10 ◽  
Author(s):  
Guillaume Attuel ◽  
Evgeniya Gerasimova-Chechkina ◽  
Françoise Argoul ◽  
Hussein Yahia ◽  
Alain Arneodo
Keyword(s):  
Atrial Fibrillation ◽  
Excitable Cell ◽  
Cell Network

scholarly journals Edoxaban: A Comprehensive Review of the Pharmacology and Clinical Data for the Management of Atrial Fibrillation and Venous Thromboembolism

2016 ◽  
Vol 5 (1) ◽  
pp. 1-18 ◽  
Author(s):  
Zachary A. Stacy ◽  
William B. Call ◽  
Aaron P. Hartmann ◽  
Golden L. Peters ◽  
Sara K. Richter
Keyword(s):  
Atrial Fibrillation ◽  
Venous Thromboembolism ◽  
Clinical Data ◽  
Comprehensive Review

Abstract 3681: Early Anticoagulation Is Not Associated With Hemorrhagic Transformation Of Ischemic Stroke In Patients With Atrial Fibrillation

Stroke ◽  
2012 ◽  
Vol 43 (suppl_1) ◽  
Author(s):  
H. B Brouwers ◽  
Svetlana Lorenzano ◽  
Lyndsey H Starks ◽  
David M Greer ◽  
Steven K Feske ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Clinical Data ◽  
Infarct Volume ◽  
Hemorrhagic Transformation ◽  
P Value ◽  
Long Term Outcome ◽  
Nihss Score

Purpose: Hemorrhagic transformation (HT) is a common and potentially devastating complication of ischemic stroke, however its prevalence, predictors, and outcome remain unclear. Early anticoagulation is thought to be a risk factor for HT which raises the clinical question when to (re)start anticoagulation in ischemic stroke patients who have a compelling indication, such as atrial fibrillation. We conducted a prospective cohort study to address this question and to identify association of hemorrhagic transformation with outcome measures in patients with atrial fibrillation in the setting of acute ischemic stroke. Materials and Methods: We performed a prospective study which enrolled consecutive patients admitted with acute ischemic stroke presenting to a single center over a three-year period. As part of the observational study, baseline clinical data and stroke characteristics as well as 3 month functional outcome were collected. For this sub-study, we restricted the analysis to subjects diagnosed with atrial fibrillation. CT and MRI scans were reviewed by experienced readers, blinded to clinical data, to assess for hemorrhagic transformation (using ECASS 2 criteria), microbleeds and infarct volumes in both admission and follow-up scans. Clinical and outcome data were analyzed for association with hemorrhagic transformation. Results: Of 94 patients, 63 had a history of atrial fibrillation (67.0%) and 31 had newly discovered atrial fibrillation (33.0%). We identified HT in 3 of 94 baseline scans (3.2%) and 22 of 48 follow-up scans (45.8%) obtained a median of 3 days post-stroke. In-hospital initiation of either anti-platelet (n = 36; OR 0.34 [95% CI 0.10-1.16], p-value = 0.09) or anticoagulation with unfractionated intravenous heparin or low molecular weight heparin (n = 72; OR 0.25 [95% CI 0.06-1.15], p-value = 0.08) was not associated with HT. Initial NIH Stroke Scale (NIHSS) score (median 13.0 [IQR 15.0] vs. 7.0 [IQR 10.0], p-value = 0.029) and baseline infarct volume (median 17 [IQR 42.03] vs. 5 [IQR 10.95], p-value = 0.011) were significantly higher in patients with HT compared to those without. Hemorrhagic transformation was associated with a significantly higher 48-hour median NIHSS score (20 [IQR 3.0] vs. 2 [IQR 3.25], p-value = 0.007) and larger final infarct volume (81.40 [IQR 82.75] vs. 9.95 [IQR 19.73], p-value < 0.001). Finally, we found a trend towards poorer 3-month modified Rankin Scale scores in subjects with HT (OR 11.25 [95% CI 0.97-130.22], p-value = 0.05). Conclusion: In patients with atrial fibrillation, initial NIHSS score and baseline infarct volume are associated with hemorrhagic transformation in acute ischemic stroke. Early initiation of antithrombotic therapy was not associated with hemorrhagic transformation. Patients with hemorrhagic transformation were found to have a poorer short and long term outcome and larger final infarct volumes.

The Impact of New and Emerging Clinical Data on Treatment Strategies for Atrial Fibrillation

2010 ◽  
pp. no-no ◽  
Author(s):  
ERIC N PRYSTOWSKY ◽  
JOHN CAMM ◽  
GREGORY Y.H. LIP ◽  
MAURITS ALLESSIE ◽  
JEAN-FRANÇOIS BERGMANN ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Data ◽  
Treatment Strategies ◽  
The Impact

scholarly journals Ten years of non-vitamin K antagonists oral anticoagulants for stroke prevention in atrial fibrillation: is warfarin obsolete?

2020 ◽  
Vol 22 (Supplement_O) ◽  
pp. O28-O41
Author(s):  
Matthias Hammwöhner ◽  
Andreas Goette
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Data ◽  
Vitamin K ◽  
Stroke Prevention ◽  
Vitamin K Antagonists ◽  
Oral Anticoagulants ◽  
Study Data ◽  
Phase Iii ◽  
Clinical Settings ◽  
Specific Patient

Abstract Currently, four non-vitamin K antagonists oral anticoagulants (NOACs) are available for stroke prevention in atrial fibrillation (AF). These have been in clinical use for up to 10 years now. Besides data of the initial phase III clinical trials, now clinical data, several sub-studies, meta-analyses, and studies in special clinical settings and specific patient populations are available. This review shall give an overview on the history of NOAC development, sum up study data and ‘real-world’ clinical data as well as discuss several special clinical settings like NOAC treatment in patients that require coronary artery stenting or cardioversion (CV). Furthermore, treatment considerations in special patient populations like patients with renal impairment, obesity, or patients requiring NOACs for secondary prevention are discussed. The significance of NOAC treatment will be discussed under consideration of the recently published 2020 ESC/EACTS Guidelines for the diagnosis and management of AF.

scholarly journals Wavelet leader multifractal analysis of heart rate variability in atrial fibrillation

2018 ◽  
Vol 51 (6) ◽  
pp. S83-S87 ◽  
Author(s):  
Kais Gadhoumi ◽  
Duc Do ◽  
Fabio Badilini ◽  
Michele M. Pelter ◽  
Xiao Hu
Keyword(s):  
Atrial Fibrillation ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Multifractal Analysis

scholarly journals A jobb pitvari fülcse echokardiográfiás vizsgálata és annak klinikai jelentősége

2019 ◽  
Vol 160 (12) ◽  
pp. 443-447
Author(s):  
Attila Nemes ◽  
Kálmán Havasi ◽  
László Sághy ◽  
Mária Kohári ◽  
Tamás Forster
Keyword(s):  
Atrial Fibrillation ◽  
Clinical Data ◽  
Thrombus Formation ◽  
Atrial Appendage ◽  
Present Review ◽  
Right Atrial ◽  
Right Heart ◽  
Right Atrial Appendage ◽  
The Right

Abstract: In case of atrial fibrillation, there is a higher risk of thrombus formation, which could affect the right heart as well. Visualization of the right atrial appendage is difficult; the aim of the present review was to demonstrate the role of routine echocardiographic techniques and to show related clinical data. Orv Hetil. 2019; 160(12): 443–447.

Multifractal analysis for grading complex fractionated electrograms in atrial fibrillation

2015 ◽  
Vol 36 (11) ◽  
pp. 2269-2284 ◽  
Author(s):  
A Orozco-Duque ◽  
D Novak ◽  
V Kremen ◽  
J Bustamante
Keyword(s):  
Atrial Fibrillation ◽  
Multifractal Analysis ◽  
Fractionated Electrograms
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