scholarly journals Variability in Tidal Volume Affects Lung and Cardiovascular Function Differentially in a Rat Model of Experimental Emphysema

2017 ◽  
Vol 8 ◽  
Author(s):  
Caio G. R. S. Wierzchon ◽  
Gisele Padilha ◽  
Nazareth N. Rocha ◽  
Robert Huhle ◽  
Mariana S. Coelho ◽  
...  
Keyword(s):  
Tidal Volume ◽  
Rat Model ◽  
Cardiovascular Function ◽  
Experimental Emphysema

Maternal treatment with a placental-targeted antioxidant (MitoQ) impacts offspring cardiovascular function in a rat model of prenatal hypoxia

2018 ◽  
Vol 134 ◽  
pp. 332-342 ◽  
Author(s):  
Mais M. Aljunaidy ◽  
Jude S. Morton ◽  
Raven Kirschenman ◽  
Tom Phillips ◽  
C. Patrick Case ◽  
...  
Keyword(s):  
Rat Model ◽  
Cardiovascular Function ◽  
Prenatal Hypoxia ◽  
Maternal Treatment

scholarly journals Desflurane Attenuates Ventilator-Induced Lung Injury in Rats with Acute Respiratory Distress Syndrome

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Xue Lin ◽  
Ying-nan Ju ◽  
Wei Gao ◽  
Dong-mei Li ◽  
Chang-chun Guo
Keyword(s):  
Acute Respiratory Distress Syndrome ◽  
Lung Injury ◽  
Respiratory Distress Syndrome ◽  
Respiratory Distress ◽  
Tidal Volume ◽  
Lung Tissue ◽  
Rat Model ◽  
Distress Syndrome ◽  
Inflammatory Factors ◽  
Ventilator Induced Lung Injury

Ventilator-induced lung injury aggravates the existing lung injury. This study investigated the effect of desflurane on VILI in a rat model of acute respiratory distress syndrome. Forty-eight rats were randomized into a sham (S) group, control (C) group, lipopolysaccharide/ventilation (LV) group, lipopolysaccharide/ventilation/desflurane (LVD) group, or lipopolysaccharide/low ventilation with and without desflurane (LLV and LLVD) groups. Rats in the S group received anesthesia only. Rats in the LV and LVD groups received lipopolysaccharide and were ventilated with a high tidal volume. Rats in LLV and LLVD groups were treated as the LV and LVD groups and ventilated with a low tidal volume. PaO2/FiO2, lung wet-to-dry weight ratios, concentrations of inflammatory factors in serum and BALF, histopathologic analysis of lung tissue, and levels of nuclear factor- (NF-) κB protein in lung tissue were investigated. PaO2/FiO2 was significantly increased by desflurane. Total cell count, macrophages, and neutrophils in BALF and proinflammatory factors in BALF and serum were significantly decreased by desflurane, while IL-10 was increased. The histopathological changes and levels of NF-κB protein in lung tissue were decreased by desflurane. The results indicated that desflurane ameliorated VILI in a rat model of acute respiratory distress syndrome.

scholarly journals Cardiovascular Function in a Rat Model of Diet-Induced Obesity

Hypertension ◽  
2006 ◽  
Vol 48 (1) ◽  
pp. 65-72 ◽  
Author(s):  
Joan F. Carroll ◽  
Woineshet J. Zenebe ◽  
Taylor B. Strange
Keyword(s):  
Rat Model ◽  
Cardiovascular Function ◽  
Diet Induced Obesity

scholarly journals Effects of vardenafil, a selective phosphodiesterase-5-inhibitor, on cardiovascular function in a rat model

2007 ◽  
Vol 7 (Suppl 1) ◽  
pp. P39 ◽  
Author(s):  
Sivakkanan Loganathan ◽  
Tamás Radovits ◽  
Iwan R Wirotanseng ◽  
Gábor Veres ◽  
Siegfried Hagl ◽  
...  
Keyword(s):  
Rat Model ◽  
Cardiovascular Function ◽  
Phosphodiesterase 5 Inhibitor ◽  
Phosphodiesterase 5

scholarly journals Ghrelin therapy improves lung and cardiovascular function in experimental emphysema

2017 ◽  
Vol 18 (1) ◽  
Author(s):  
Nazareth de Novaes Rocha ◽  
Milena Vasconcellos de Oliveira ◽  
Cássia Lisboa Braga ◽  
Gabriela Guimarães ◽  
Lígia de Albuquerque Maia ◽  
...  
Keyword(s):  
Cardiovascular Function ◽  
Experimental Emphysema

Effects of Vardenafil, a selective phosphodiesterase-5-inhibitor, on cardiovascular function in a rat model

2007 ◽  
Vol 55 (S 1) ◽  
Author(s):  
S Loganathan ◽  
T Radovits ◽  
I Wiratonseng ◽  
G Veres ◽  
J Hütter ◽  
...  
Keyword(s):  
Rat Model ◽  
Cardiovascular Function ◽  
Phosphodiesterase 5 Inhibitor ◽  
Phosphodiesterase 5

scholarly journals A novel DDAH-1 inhibitor improved cardiovascular function in a short-term anesthetized rat model of sepsis

Critical Care ◽  
2011 ◽  
Vol 15 (S3) ◽  
Author(s):  
Z Wang ◽  
V Taylor ◽  
R Stidwill ◽  
J Leiper ◽  
M Singer
Keyword(s):  
Rat Model ◽  
Cardiovascular Function ◽  
Short Term
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