scholarly journals Higher Daily Physical Activity Level Is Associated with Lower RBC Aggregation in Carotid Artery Disease Patients at High Risk of Stroke

2017 ◽  
Vol 8 ◽  
Author(s):  
Pauline Mury ◽  
Camille Faes ◽  
Antoine Millon ◽  
Mathilde Mura ◽  
Céline Renoux ◽  
...  
Keyword(s):  
Physical Activity ◽  
High Risk ◽  
Carotid Artery ◽  
Physical Activity Level ◽  
Carotid Artery Disease ◽  
Daily Physical Activity ◽  
Activity Level ◽  
Rbc Aggregation ◽  
Artery Disease

Genetic analysis of daily physical activity using a mouse chromosome substitution strain

2009 ◽  
Vol 39 (1) ◽  
pp. 47-55 ◽  
Author(s):  
He S. Yang ◽  
Martha H. Vitaterna ◽  
Aaron D. Laposky ◽  
Kazuhiro Shimomura ◽  
Fred W. Turek
Keyword(s):  
Physical Activity ◽  
Physical Activity Level ◽  
Wheel Running ◽  
Daily Physical Activity ◽  
Activity Level ◽  
Constant Darkness ◽  
Circadian Period ◽  
Chromosome 13 ◽  
Running Activity ◽  
Wheel Running Activity

There is considerable evidence for a genetic basis underlying individual differences in spontaneous physical activity in humans and animals. Previous publications indicate that the physical activity level and pattern vary among inbred strains of mice and identified a genomic region on chromosome 13 as quantitative trait loci (QTL) for physical activity. To confirm and further characterize the role of chromosome 13 in regulating daily physical activity level and pattern, we conducted a comprehensive phenotypic study in the chromosome 13 substitution strain (CSS-13) in which the individual chromosome 13 from the A/J strain was substituted into an otherwise complete C57BL/6J (B6) genome. The B6 and A/J parental strains exhibited pronounced differences in daily physical activity, sleep-wake structure, circadian period and body weight. Here we report that a single A/J chromosome 13 in the context of a B6 genetic background conferred a profound reduction in both total cage activity and wheel-running activity under a 14:10-h light-dark cycle, as well as in constant darkness, compared with B6 controls. Additionally, CSS-13 mice differed from B6 controls in the diurnal distribution of activity and the day-to-day variability in activity onset. We further performed a linkage analysis and mapped a significant QTL on chromosome 13 regulating the daily wheel running activity level in mice. Taken together, our findings indicate a QTL on chromosome 13 with dramatic and specific effects on daily voluntary physical activity, but not on circadian period, sleep, or other aspects of activity that are different between B6 and A/J strains.

Angioplasty and stenting for carotid artery stenosis: indications, techniques, results, and complications

1998 ◽  
Vol 5 (6) ◽  
pp. E5 ◽  
Author(s):  
Giuseppe Lanzino ◽  
Richard D. Fessler ◽  
Robert A. Mericle ◽  
Ajay K. Wakhloo ◽  
Lee R. Guterman ◽  
...  
Keyword(s):  
High Risk ◽  
Carotid Artery ◽  
Carotid Artery Stenosis ◽  
Carotid Artery Disease ◽  
Artery Stenosis ◽  
High Risk Patients ◽  
Clinical Series ◽  
Risk Patients ◽  
Artery Disease ◽  
Angioplasty And Stenting

Following the favorable results obtained in the treatment of coronary artery disease, combined angioplasty and stenting has been advocated for the treatment of carotid artery stenosis as well. Although widespread application of angioplasty and stenting for carotid artery disease is neither indicated nor recommended, it may be a viable alternative therapy for select patients who are high-risk patients for surgery. The results of early series have suggested that endoluminal revascularization in these high-risk patients can be performed with an acceptable degree of safety. Although the incidence of death and major stroke rates following angioplasty and stenting procedures compares favorably with surgery, results of more recent clinical series have suggested that the incidence of perioperative transient neurological events and minor strokes may be higher than suggested by earlier reports, especially in patients with recent neurological symptoms and “unstable” plaques. In this article, the authors review the current potential indications for and preliminary results of angioplasty and stenting and describe their procedural technique. In addition, potential applications of stenting to intracranial thromboocclusive carotid artery disease are reviewed.

Daily Physical Activity Level in Male Inbred Mouse Strains

2004 ◽  
Vol 36 (Supplement) ◽  
pp. S260
Author(s):  
Meredith G. Daves ◽  
Michael J. Turner ◽  
Steven R. Kleeberger ◽  
J Timothy Lightfoot
Keyword(s):  
Physical Activity ◽  
Physical Activity Level ◽  
Inbred Mouse ◽  
Daily Physical Activity ◽  
Activity Level ◽  
Mouse Strains ◽  
Inbred Mouse Strains

scholarly journals Focused screening for occult carotid artery disease: patients with known heart disease are at high risk

2004 ◽  
Vol 39 (1) ◽  
pp. 44-50 ◽  
Author(s):  
Caron B Rockman ◽  
Glenn R Jacobowitz ◽  
Paul J Gagne ◽  
Mark A Adelman ◽  
Patrick J Lamparello ◽  
...  
Keyword(s):  
Heart Disease ◽  
High Risk ◽  
Carotid Artery ◽  
Carotid Artery Disease ◽  
Artery Disease
Sign in / Sign up

Export Citation Format

Share Document