scholarly journals The Gly16 Allele of the G16R Single Nucleotide Polymorphism in the β2-Adrenergic Receptor Gene Augments the Glycemic Response to Adrenaline in Humans

2017 ◽  
Vol 8 ◽  
Author(s):  
Kim Z. Rokamp ◽  
Jonatan M. Staalsø ◽  
Morten Zaar ◽  
Peter Rasmussen ◽  
Lonnie G. Petersen ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Glycemic Response ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Β2 Adrenergic Receptor ◽  
Adrenergic Receptor Gene

G16R single nucleotide polymorphism but not haplotypes of the β2-adrenergic receptor gene alters cardiac output in humans

2013 ◽  
Vol 125 (4) ◽  
pp. 191-198 ◽  
Author(s):  
Kim Z. Rokamp ◽  
Jonatan M. Staalsoe ◽  
Martin Gartmann ◽  
Anna Sletgaard ◽  
Nicolai B. Nordsborg ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Cardiac Output ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Model Flow ◽  
Genes Encoding ◽  
Β2 Adrenergic Receptor ◽  
Cardiovascular Variables

Variation in genes encoding the β2-adrenergic receptor (ADRB2) and angiotensin-converting enzyme (ACE) may influence Q̇ (cardiac output). The 46G>A (G16R) SNP (single nucleotide polymorphism) has been associated with β2-mediated vasodilation, but the effect of ADRB2 haplotypes on Q̇ has not been studied. Five SNPs within ADRB2 (46G>A, 79C>G, 491C>T, 523C>A and 1053G>C by a pairwise tagging principle) and the I/D (insertion/deletion) polymorphism in ACE were genotyped in 143 subjects. Cardiovascular variables were evaluated by the Model flow method at rest and during incremental cycling exercise. Only the G16R polymorphism was associated with Q̇. In carriers of the Arg16 allele, Q̇rest (resting Q̇) was 0.4 [95% CI (confidence interval), 0.0–0.7] l/min lower than in G16G homozygotes (P=0.048). During exercise, the increase in Q̇ was by 4.7 (95% CI, 4.3–5.2) l/min per litre increase in pulmonary V̇O2 (oxygen uptake) in G16G subjects, but the increase was 0.5 (0.0–0.9) l/min lower in Arg16 carriers (P=0.035). A similar effect size was observed for the Arg16 haplotypes ACCCG and ACCCC. No interaction was found between ADRB2 and ACE polymorphisms. During exercise, the increase in Q̇ was 0.5 (CI, 0.0 –1.0) l/min greater in ACE I/I carriers compared with I/D and D/D subjects (P=0.054). In conclusion, the ADRB2 Arg16 allele in humans is associated with a lower Q̇ both at rest and during exercise, overriding the effects of haplotypes.

Automated detection of single nucleotide polymorphism in β-2 adrenergic receptor gene using LCx®

2001 ◽  
Vol 308 (1-2) ◽  
pp. 17-24 ◽  
Author(s):  
Hong Yu ◽  
Barbara Merchant ◽  
Christi Scheffel ◽  
Chandri Yandava ◽  
Jeffrey M. Drazen ◽  
...  
Keyword(s):  
Single Nucleotide Polymorphism ◽  
Adrenergic Receptor ◽  
Receptor Gene ◽  
Automated Detection ◽  
Nucleotide Polymorphism ◽  
Single Nucleotide ◽  
Adrenergic Receptor Gene
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