scholarly journals Sex-Specific Impact of Ischemic Preconditioning on Tissue Oxygenation and Maximal Concentric Force

2017 ◽  
Vol 7 ◽  
Author(s):  
Pénélope Paradis-Deschênes ◽  
Denis R. Joanisse ◽  
François Billaut
Keyword(s):  
Ischemic Preconditioning ◽  
Tissue Oxygenation ◽  
Concentric Force ◽  
Specific Impact

scholarly journals Remote Ischemic Preconditioning Improves Tissue Oxygenation in a Porcine Model of Controlled Hemorrhage Without Fluid Resuscitation

2021 ◽  
Author(s):  
Gal Yaniv ◽  
Arik Eisenkraft ◽  
Lilach Gavish ◽  
Linn Wagnert-Avraham ◽  
Dean Nachman ◽  
...  
Keyword(s):  
Ischemic Preconditioning ◽  
Cellular Response ◽  
Tissue Oxygenation ◽  
Porcine Model ◽  
Fluid Replacement ◽  
Remote Ischemic Preconditioning ◽  
Tissue Oxygen ◽  
Oxygen Extraction Ratio ◽  
Chi Square ◽  
Field Situation

Abstract Purpose Remote Ischemic preconditioning (RIPC) involves deliberate, brief interruptions of blood flow to increase the tolerance of distant critical organs to ischemia. This study tests the effects of limb RIPC in a porcine model of controlled hemorrhage without replacement therapy simulating an extreme field situation of delayed evacuation to definitive care.Methods Twenty-eight pigs (47±6kg) were assigned to: (1) control, no procedure (n=7); (2) HS=hemorrhagic shock (n=13); and (3) RIPC+HS=remote ischemic preconditioning followed by hemorrhage (n=8). The animals were observed for 7 hours after bleeding without fluid replacement. Results Survival rate between animals that underwent RIPC before bleeding and those bled without prior RIPC were similar (HS, 6 of 13[46%]-vs-RIPC+HS, 4 of 8[50%], p=0.86 by Chi-square). Animals with prior RIPC had faster recovery of mean arterial pressure and developed higher heart rates without complications. Those with RIPC had less decrease in pH and bicarbonate, and the increase in lactate began later. Global oxygen delivery was higher, and tissue oxygen extraction ratio lower, in animals bled after RIPC. Conclusions These improvements after RIPC in hemodynamic and metabolic status provide essential substrates for improved cellular response after hemorrhage and reduction of the likelihood of potentially catastrophic consequences of the accompanying ischemia.

Ischemic Preconditioning of Skeletal Muscle Improves Tissue Oxygenation During Reperfusion

1999 ◽  
Vol 15 (03) ◽  
pp. 223-228 ◽  
Author(s):  
Keith Attkiss ◽  
Mark Suski ◽  
T. Hunt ◽  
Harry Buncke
Keyword(s):  
Skeletal Muscle ◽  
Ischemic Preconditioning ◽  
Tissue Oxygenation

scholarly journals Effect of ischemic preconditioning and changing inspired O2 fractions on neuromuscular function during intense exercise

2019 ◽  
Vol 127 (6) ◽  
pp. 1688-1697 ◽  
Author(s):  
Samuel L. Halley ◽  
Paul Marshall ◽  
Jason C. Siegler
Keyword(s):  
Ischemic Preconditioning ◽  
Near Infrared ◽  
Tissue Oxygenation ◽  
Femoral Nerve ◽  
Humoral Response ◽  
Neuromuscular Function ◽  
Voluntary Activation ◽  
Hypoxic Conditions ◽  
Fraction Of Inspired Oxygen ◽  
Inspired Oxygen

The aim of the present study was to determine whether ischemic preconditioning (IPC)-mediated effects on neuromuscular function are dependent on tissue oxygenation. Eleven resistance-trained males completed four exercise trials (6 sets of 11 repetitions of maximal effort dynamic single-leg extensions) in either normoxic [fraction of inspired oxygen ([Formula: see text]): 21%) or hypoxic [Formula: see text]: 14%] conditions, preceded by treatments of either IPC (3 × 5 min bilateral leg occlusions at 220 mmHg) or sham (3 × 5 min at 20 mmHg). Femoral nerve stimulation was utilized to assess voluntary activation and potentiated twitch characteristics during maximal voluntary contractions (MVCs). Tissue oxygenation (via near-infrared spectroscopy) and surface electromyography activity were measured throughout the exercise task. MVC and twitch torque declined 62 and 54%, respectively (MVC: 96 ± 24 N·m, Cohen’s d = 2.9, P < 0.001; twitch torque: 37 ± 11 N·m, d = 1.6, P < 0.001), between pretrial measurements and the sixth set without reductions in voluntary activation ( P > 0.21); there were no differences between conditions. Tissue oxygenation was reduced in both hypoxic conditions compared with normoxia ( P < 0.001), with an even further reduction of 3% evident in the hypoxic IPC compared with the sham trial (mean decrease 1.8 ± 0.7%, d = 1.0, P < 0.05). IPC did not affect any measure of neuromuscular function regardless of tissue oxygenation. A reduction in [Formula: see text] did invoke a humoral response and improved muscle O2 extraction during exercise, however, it did not manifest into any performance benefit. NEW & NOTEWORTHY Ischemic preconditioning did not affect any facet of neuromuscular function regardless of the degree of tissue oxygenation. Reducing the fraction of inspired oxygen induced localized tissue deoxygenation, subsequently invoking a humoral response, which improved muscle oxygen extraction during exercise. This physiological response, however, did not manifest into any performance benefits.

The relationship of hepatic tissue oxygenation with nitric oxide metabolism in ischemic preconditioning of the liver

2002 ◽  
Vol 16 (12) ◽  
pp. 1654-1656 ◽  
Author(s):  
Rahul S. Koti ◽  
Alexander M. Seifalian ◽  
Alan G. McBride ◽  
Wenxuan Yang ◽  
Brian R. Davidson
Keyword(s):  
Nitric Oxide ◽  
Ischemic Preconditioning ◽  
Tissue Oxygenation ◽  
Hepatic Tissue ◽  
Nitric Oxide Metabolism ◽  
Relationship Of ◽  
The Relationship

scholarly journals Remote ischemic preconditioning improves tissue oxygenation in a porcine model of controlled hemorrhage without fluid resuscitation

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Gal Yaniv ◽  
Arik Eisenkraft ◽  
Lilach Gavish ◽  
Linn Wagnert-Avraham ◽  
Dean Nachman ◽  
...  
Keyword(s):  
Ischemic Preconditioning ◽  
Cellular Response ◽  
Tissue Oxygenation ◽  
Porcine Model ◽  
Fluid Replacement ◽  
Remote Ischemic Preconditioning ◽  
Tissue Oxygen ◽  
Oxygen Extraction Ratio ◽  
Chi Square ◽  
Field Situation

AbstractRemote ischemic preconditioning (RIPC) involves deliberate, brief interruptions of blood flow to increase the tolerance of distant critical organs to ischemia. This study tests the effects of limb RIPC in a porcine model of controlled hemorrhage without replacement therapy simulating an extreme field situation of delayed evacuation to definitive care. Twenty-eight pigs (47 ± 6 kg) were assigned to: (1) control, no procedure (n = 7); (2) HS = hemorrhagic shock (n = 13); and (3) RIPC + HS = remote ischemic preconditioning followed by hemorrhage (n = 8). The animals were observed for 7 h after bleeding without fluid replacement. Survival rate between animals of the RIPC + HS group and those of the HS group were similar (HS, 6 of 13[46%]-vs-RIPC + HS, 4 of 8[50%], p = 0.86 by Chi-square). Animals of the RIPC + HS group had faster recovery of mean arterial pressure and developed higher heart rates without complications. They also had less decrease in pH and bicarbonate, and the increase in lactate began later. Global oxygen delivery was higher, and tissue oxygen extraction ratio lower, in RIPC + HS animals. These improvements after RIPC in hemodynamic and metabolic status provide essential substrates for improved cellular response after hemorrhage and reduction of the likelihood of potentially catastrophic consequences of the accompanying ischemia.

877: The Effect of Arterial Versus Arteriovenous Clamping on Renal Tissue Oxygenation in a Porcine Model

2006 ◽  
Vol 175 (4S) ◽  
pp. 283-284
Author(s):  
Luke M. Fazio ◽  
Alexandra E. Perks ◽  
Brian D.M. Blew ◽  
Greg T. Hare ◽  
David Mazer ◽  
...  
Keyword(s):  
Tissue Oxygenation ◽  
Porcine Model ◽  
Renal Tissue

In vivo ischemic preconditioning by caspase-3 cleavage of poly(ADP-ribose) polymerase-1

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S305-S305
Author(s):  
Philippe E Garnier ◽  
San Won Suh ◽  
Weihai Ying ◽  
Raymond A Swanson
Keyword(s):  
Ischemic Preconditioning ◽  
Caspase 3

Ischemic preconditioning protects the hippocampal CA1 neurons by inhibiting synaptic activity in rat

2005 ◽  
Vol 25 (1_suppl) ◽  
pp. S300-S300
Author(s):  
Thomas J Sick ◽  
Ami P Raval ◽  
Isabel Saul ◽  
Kunjan R Dave ◽  
Raul Busto ◽  
...  
Keyword(s):  
Ischemic Preconditioning ◽  
Synaptic Activity ◽  
Ca1 Neurons ◽  
Hippocampal Ca1 Neurons ◽  
Hippocampal Ca1
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