scholarly journals A Lumped-Parameter Subject-Specific Model of Blood Volume Response to Fluid Infusion

2016 ◽  
Vol 7 ◽  
Author(s):  
Ramin Bighamian ◽  
Andrew T. Reisner ◽  
Jin-Oh Hahn
Keyword(s):  
Blood Volume ◽  
Specific Model ◽  
Fluid Infusion ◽  
Lumped Parameter ◽  
Subject Specific ◽  
Volume Response

scholarly journals Credibility Assessment of a Subject-Specific Mathematical Model of Blood Volume Kinetics for Prediction of Physiological Response to Hemorrhagic Shock and Fluid Resuscitation

2021 ◽  
Vol 12 ◽  
Author(s):  
Bahram Parvinian ◽  
Ramin Bighamian ◽  
Christopher George Scully ◽  
Jin-Oh Hahn ◽  
Pras Pathmanathan
Keyword(s):  
Mathematical Model ◽  
Blood Volume ◽  
Fluid Resuscitation ◽  
Predictive Capability ◽  
Calibration And Validation ◽  
Subject Specific ◽  
Volume Response ◽  
Validation Tests ◽  
Volume Kinetics ◽  
The Mathematical Model

Subject-specific mathematical models for prediction of physiological parameters such as blood volume, cardiac output, and blood pressure in response to hemorrhage have been developed. In silico studies using these models may provide an effective tool to generate pre-clinical safety evidence for medical devices and help reduce the size and scope of animal studies that are performed prior to initiation of human trials. To achieve such a goal, the credibility of the mathematical model must be established for the purpose of pre-clinical in silico testing. In this work, the credibility of a subject-specific mathematical model of blood volume kinetics intended to predict blood volume response to hemorrhage and fluid resuscitation during fluid therapy was evaluated. A workflow was used in which: (i) the foundational properties of the mathematical model such as structural identifiability were evaluated; (ii) practical identifiability was evaluated both pre- and post-calibration, with the pre-calibration results used to determine an optimal splitting of experimental data into calibration and validation datasets; (iii) uncertainty in model parameters and the experimental uncertainty were quantified for each subject; and (iv) the uncertainty was propagated through the blood volume kinetics model and its predictive capability was evaluated via validation tests. The mathematical model was found to be structurally identifiable. Pre-calibration identifiability analysis led to splitting the 180 min of time series data per subject into 50 and 130 min calibration and validation windows, respectively. The average root mean squared error of the mathematical model was 12.6% using the calibration window of (0 min, 50 min). Practical identifiability was established post-calibration after fixing one of the parameters to a nominal value. In the validation tests, 82 and 75% of the subject-specific mathematical models were able to correctly predict blood volume response when predictive capability was evaluated at 180 min and at the time when amount of infused fluid equals fluid loss.

Markerless Motion Capture through Visual Hull, Articulated ICP and Subject Specific Model Generation

2009 ◽  
Vol 87 (1-2) ◽  
pp. 156-169 ◽  
Author(s):  
Stefano Corazza ◽  
Lars Mündermann ◽  
Emiliano Gambaretto ◽  
Giancarlo Ferrigno ◽  
Thomas P. Andriacchi
Keyword(s):  
Motion Capture ◽  
Specific Model ◽  
Model Generation ◽  
Visual Hull ◽  
Markerless Motion Capture ◽  
Subject Specific

Large-scale blood flow analysis using subject-specific model of cerebral arteries

2019 ◽  
Vol 2019.32 (0) ◽  
pp. 238
Author(s):  
Yuima KOBAYASHI ◽  
Shunichi ISHIDA ◽  
Naoki TAKEISHI ◽  
Yohsuke IMAI ◽  
Shigeo WADA
Keyword(s):  
Blood Flow ◽  
Large Scale ◽  
Cerebral Arteries ◽  
Flow Analysis ◽  
Specific Model ◽  
Subject Specific ◽  
Blood Flow Analysis

Blood Volume Response to Extracorporeal Circulation in Dogs

1979 ◽  
Vol 13 (2) ◽  
pp. 73-78
Author(s):  
Claude Chartrand ◽  
André Brassard ◽  
Paul Stanley
Keyword(s):  
Blood Volume ◽  
Extracorporeal Circulation ◽  
Volume Response

Active and passive control of hepatic blood volume responses to hemorrhage at normal and raised hepatic venous pressure in cats

1980 ◽  
Vol 58 (9) ◽  
pp. 1049-1057 ◽  
Author(s):  
W. Wayne Lautt ◽  
L. Cheryle Brown ◽  
J. Scott Durham
Keyword(s):  
Blood Flow ◽  
Blood Loss ◽  
Blood Volume ◽  
Passive Control ◽  
Venous Pressure ◽  
Liver Volume ◽  
Passive Flow ◽  
Hepatic Volume ◽  
Volume Response

Hepatic blood volume decreases in response to a rapid hemorrhage (15.3 mL/min) were measured in cats anesthetized with pentobarbital or ketamine–chloralose, by use of in vivo plethysmography alone or in combination with various surgical procedures and vascular circuits. The hepatic blood volume contracts during hemorrhage to compensate for a constant proportion (26 ± 6%) of the blood loss regardless of the extent of the actual blood loss. Following denervation of the liver and α adrenoreceptor blockade (3 mg phentolamine, intraportal) the liver compensation was unaltered. After denervation, nephrectomy, hypophysectomy, and adrenalectomy the liver was still able to compensate for 20 ± 7.4% of the hemorrhage. Decreases in liver volume were linearly related to decreases in total hepatic blood flow that ensued whether the decreased blood flow was induced by hemorrhage or by clamping of the arteries supplying the splanchnic organs (superior mesenteric artery, celiac artery). The hepatic volume response to hemorrhage could be predicted accurately (97 ± 6.6%) simply from the linear passive relationship between flow and volume for a particular animal. However when hepatic venous pressure was experimentally elevated, the volume response to passive flow decrease was markedly reduced whereas the response to hemorrhage and noradrenaline infusion was unimpaired suggesting that active control factors were required to produce normal hepatic volume responses to hemorrhage at raised venous pressure. Phentolamine reduced the response at raised venous pressure but was without effect at normal venous pressure in the same animal, indicating that the hepatic nerves and (or) adrenal catecholamines are of paramount importance in control of the response at raised venous pressure when the passive flow influence is much reduced.

scholarly journals Local cerebral blood volume response to carbon dioxide in man.

1978 ◽  
Vol 43 (2) ◽  
pp. 324-331 ◽  
Author(s):  
J H Greenberg ◽  
A Alavi ◽  
M Reivich ◽  
D Kuhl ◽  
B Uzzell
Keyword(s):  
Carbon Dioxide ◽  
Blood Volume ◽  
Cerebral Blood Volume ◽  
Volume Response
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