scholarly journals Muscle-Specific Myosin Heavy Chain Shifts in Response to a Long-Term High Fat/High Sugar Diet and Resveratrol Treatment in Nonhuman Primates

2016 ◽  
Vol 7 ◽  
Author(s):  
Jon-Philippe K. Hyatt ◽  
Lisa Nguyen ◽  
Allison E. Hall ◽  
Ashley M. Huber ◽  
Jessica C. Kocan ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Nonhuman Primates ◽  
High Fat ◽  
High Sugar ◽  
Resveratrol Treatment ◽  
Chain Shifts

Long‐term insulin treatment leads to a change in myosin heavy chain fiber distribution in OLETF rat skeletal muscle

2018 ◽  
Vol 120 (2) ◽  
pp. 2404-2412 ◽  
Author(s):  
Oak‐Kee Hong ◽  
Yoon‐Hee Choi ◽  
Hyuk‐Sang Kwon ◽  
Hee‐Kyoung Jeong ◽  
Jang‐Won Son ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Insulin Treatment ◽  
Fiber Distribution ◽  
Rat Skeletal Muscle ◽  
Oletf Rat

Recovery of the soleus muscle after short- and long-term disuse induced by hindlimb unloading: effects on the electrical properties and myosin heavy chain profile

2005 ◽  
Vol 18 (2) ◽  
pp. 356-365 ◽  
Author(s):  
Jean-François Desaphy ◽  
Sabata Pierno ◽  
Antonella Liantonio ◽  
Annamaria De Luca ◽  
M. Paola Didonna ◽  
...  
Keyword(s):  
Electrical Properties ◽  
Myosin Heavy Chain ◽  
Soleus Muscle ◽  
Heavy Chain ◽  
Hindlimb Unloading ◽  
Short And Long Term

scholarly journals Resveratrol Prevents  -Cell Dedifferentiation in Nonhuman Primates Given a High-Fat/High-Sugar Diet

Diabetes ◽  
2013 ◽  
Vol 62 (10) ◽  
pp. 3500-3513 ◽  
Author(s):  
J. L. Fiori ◽  
Y.-K. Shin ◽  
W. Kim ◽  
S. M. Krzysik-Walker ◽  
I. Gonzalez-Mariscal ◽  
...  
Keyword(s):  
Nonhuman Primates ◽  
High Fat ◽  
Cell Dedifferentiation ◽  
High Sugar

Milk from dams fed an obesogenic diet combined with a high-fat/high-sugar diet induces long-term abnormal mammary gland development in the rabbit1

2015 ◽  
Vol 93 (4) ◽  
pp. 1641-1655 ◽  
Author(s):  
C. Hue-Beauvais ◽  
E. Koch ◽  
P. Chavatte-Palmer ◽  
L. Galio ◽  
S. Chat ◽  
...  
Keyword(s):  
Mammary Gland ◽  
Mammary Gland Development ◽  
High Fat ◽  
High Sugar ◽  
Obesogenic Diet ◽  
Gland Development

scholarly journals Congenital Anomalies Programmed by Maternal Diabetes and Obesity on Offspring of Rats

2021 ◽  
Vol 12 ◽  
Author(s):  
Vanessa Caruline Araujo-Silva ◽  
Alice Santos-Silva ◽  
Andressa Silva Lourenço ◽  
Cristielly Maria Barros-Barbosa ◽  
Rafaianne Queiroz Moraes-Souza ◽  
...  
Keyword(s):  
Maternal Diabetes ◽  
Diabetic Rats ◽  
Female Rats ◽  
Gravid Uterus ◽  
Oral Glucose ◽  
Standard Diet ◽  
High Fat ◽  
High Sugar ◽  
Obesity And Diabetes

Embryo-fetal exposure to maternal disorders during intrauterine life programs long-term consequences for the health and illness of offspring. In this study, we evaluated whether mild diabetic rats that were given high-fat/high-sugar (HF/HS) diet presented maternal and fetal changes at term pregnancy. Female rats received citrate buffer (non-diabetic-ND) or streptozotocin (diabetic-D) after birth. According to the oral glucose tolerance test (OGTT), the experimental groups (n = 11 animals/group) were composed of non-diabetic and diabetic receiving standard diet (S) or HF/HS diet. High-fat/high-sugar diet (30% kcal of lard) in chow and water containing 5% sucrose and given 1 month before mating and during pregnancy. During and at the end of pregnancy, obesity and diabetes features were determined. After laparotomy, blood samples, periovarian fat, and uterine content were collected. The diabetic rats presented a higher glycemia and percentage of embryonic losses when compared with the NDS group. Rats DHF/HS presented increased obesogenic index, caloric intake, and periovarian fat weight and reduced gravid uterus weight in relation to the other groups. Besides, this association might lead to the inflammatory process, confirmed by leukocytosis. Obese rats (NDHF/HS and DHF/HS) showed higher triglyceride levels and their offspring with lower fetal weight and ossification sites, indicating intrauterine growth restriction. This finding may contribute to vascular alterations related to long-term hypertensive disorders in adult offspring. The fetuses from diabetic dams showed higher percentages of skeletal abnormalities, and DHF/HS dams still had a higher rate of anomalous fetuses. Thus, maternal diabetes and/or obesity induces maternal metabolic disorders that contribute to affect fetal development and growth.

Effects of long-term creatine feeding and running on isometric functional measures and myosin heavy chain content of rat skeletal muscles

2006 ◽  
Vol 452 (6) ◽  
pp. 744-755 ◽  
Author(s):  
Maria Gallo ◽  
Tessa Gordon ◽  
Daniel Syrotuik ◽  
Yang Shu ◽  
Neil Tyreman ◽  
...  
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Skeletal Muscles ◽  
Functional Measures

Effects of inactivity on fiber size and myonuclear number in rat soleus muscle

2005 ◽  
Vol 99 (4) ◽  
pp. 1494-1499 ◽  
Author(s):  
Hui Zhong ◽  
Roland R. Roy ◽  
Boonclaire Siengthai ◽  
V. Reggie Edgerton
Keyword(s):  
Spinal Cord ◽  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Type I ◽  
Fiber Size ◽  
Rat Soleus Muscle ◽  
The Mean ◽  
Muscle Fiber Atrophy ◽  
Type I Fibers

The effects of short-term (4 days) and long-term (60 days) neuromuscular inactivity on myonuclear number, size, and myosin heavy chain (MHC) composition of isolated rat soleus fibers were determined using confocal microscopy and gel electrophoresis. Inactivity was produced via spinal cord isolation (SI), i.e., complete spinal cord transections at a midthoracic and a high sacral level and bilateral deafferentation between the transection sites. Compared with control, there was an increase in the percentage of fibers containing the faster MHC isoforms after 60, but not 4, days of SI. The mean sizes of type I and type I+IIa fibers were 41 and 27% and 66 and 56% smaller after 4 and 60 days of SI, respectively. Thus atrophy occurred earlier than the shift in myosin heavy chain (MHC) profile. The number of myonuclei was ∼30% higher in type I than type I+IIa fibers in control soleus, but after 60 days of SI these values were similar. The number of myonuclei per millimeter in type I fibers was significantly lower than control after 60 days of SI, whereas there was no change in type I+IIa fibers. Thus myonuclei were eliminated from fibers containing only type I MHC. Because the magnitude of the loss of myonuclei was less than the level of atrophy, the myonuclear domains of both type I and type I+IIa fibers were significantly lower than control. Thus chronic (60 days) inactivity results in smaller, faster fibers that contain a higher than normal amount of DNA per unit of cytoplasm. The absence of activation of muscle fibers that are normally the most active (pure type I fibers) resulted in most, but not all, fibers expressing some fast MHC isoforms. The results also indicate that a loss of myonuclei is not a prerequisite for sustained muscle fiber atrophy.

Heavy long-term ethanol consumption induces an alpha- to beta-myosin heavy chain isoform transition in rat

1999 ◽  
Vol 94 (6) ◽  
pp. 481-488 ◽  
Author(s):  
Julia Meehan ◽  
Mariann R. Piano ◽  
R. John Solaro ◽  
John M. Kennedy
Keyword(s):  
Myosin Heavy Chain ◽  
Heavy Chain ◽  
Ethanol Consumption ◽  
Myosin Heavy Chain Isoform
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