scholarly journals Skeletal muscle wasting with disuse atrophy is multi-dimensional: the response and interaction of myonuclei, satellite cells and signaling pathways

2014 ◽  
Vol 5 ◽  
Author(s):  
Naomi E. Brooks ◽  
Kathryn H. Myburgh
Keyword(s):  
Skeletal Muscle ◽  
Signaling Pathways ◽  
Satellite Cells ◽  
Muscle Wasting ◽  
Disuse Atrophy ◽  
Skeletal Muscle Wasting

scholarly journals Theaflavins decrease skeletal muscle wasting in disuse atrophy induced by hindlimb suspension in mice

2020 ◽  
Author(s):  
Kenta Suzuki ◽  
Nayuta Hirashima ◽  
Yasuyuki Fujii ◽  
Taiki Fushimi ◽  
Ayaka Yamamoto ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Wasting ◽  
Hindlimb Suspension ◽  
Disuse Atrophy ◽  
Skeletal Muscle Wasting

scholarly journals Signaling pathways underlying skeletal muscle wasting in experimental pulmonary arterial hypertension

2015 ◽  
Vol 1852 (12) ◽  
pp. 2722-2731 ◽  
Author(s):  
Daniel Moreira-Gonçalves ◽  
Ana Isabel Padrão ◽  
Rita Ferreira ◽  
Joana Justino ◽  
Rita Nogueira-Ferreira ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Pulmonary Arterial Hypertension ◽  
Arterial Hypertension ◽  
Signaling Pathways ◽  
Muscle Wasting ◽  
Skeletal Muscle Wasting ◽  
Pulmonary Arterial

The ubiquitin–proteasome system and skeletal muscle wasting

2005 ◽  
Vol 41 (1) ◽  
pp. 173 ◽  
Author(s):  
Didier Attaix ◽  
Sophie Ventadour ◽  
Audrey Codran ◽  
Daniel Béchet ◽  
Daniel Taillandier ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Muscle Wasting ◽  
Ubiquitin Proteasome System ◽  
Skeletal Muscle Wasting ◽  
Ubiquitin Proteasome

scholarly journals Mitochondrial Dysfunction Is a Common Denominator Linking Skeletal Muscle Wasting Due to Disease, Aging, and Prolonged Inactivity

Antioxidants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 588
Author(s):  
Hayden W. Hyatt ◽  
Scott K. Powers
Keyword(s):  
Skeletal Muscle ◽  
Mitochondrial Dysfunction ◽  
Chronic Diseases ◽  
Muscle Mass ◽  
Cancer Chemotherapy ◽  
Muscle Wasting ◽  
The Body ◽  
Common Denominator ◽  
Skeletal Muscle Wasting ◽  
Vital Functions

Skeletal muscle is the most abundant tissue in the body and is required for numerous vital functions, including breathing and locomotion. Notably, deterioration of skeletal muscle mass is also highly correlated to mortality in patients suffering from chronic diseases (e.g., cancer). Numerous conditions can promote skeletal muscle wasting, including several chronic diseases, cancer chemotherapy, aging, and prolonged inactivity. Although the mechanisms responsible for this loss of muscle mass is multifactorial, mitochondrial dysfunction is predicted to be a major contributor to muscle wasting in various conditions. This systematic review will highlight the biochemical pathways that have been shown to link mitochondrial dysfunction to skeletal muscle wasting. Importantly, we will discuss the experimental evidence that connects mitochondrial dysfunction to muscle wasting in specific diseases (i.e., cancer and sepsis), aging, cancer chemotherapy, and prolonged muscle inactivity (e.g., limb immobilization). Finally, in hopes of stimulating future research, we conclude with a discussion of important future directions for research in the field of muscle wasting.

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