scholarly journals Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling

2012 ◽  
Vol 3 ◽  
Author(s):  
Lilia Alberghina ◽  
Daniela Gaglio ◽  
Cecilia Gelfi ◽  
Rosa M. Moresco ◽  
Giancarlo Mauri ◽  
...  
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
System Level ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Metabolic Remodeling ◽  
Level Property ◽  
Cell Growth And Survival

scholarly journals Estrogen-induced epigenetic silencing of FTH1 and TFRC genes reduces liver cancer cell growth and survival

Epigenetics ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. 1302-1318
Author(s):  
Jibran Sualeh Muhammad ◽  
Khuloud Bajbouj ◽  
Jasmin Shafarin ◽  
Mawieh Hamad
Keyword(s):  
Cell Growth ◽  
Liver Cancer ◽  
Cancer Cell ◽  
Epigenetic Silencing ◽  
Liver Cancer Cell ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Cell Growth And Survival

scholarly journals Bone matrix osteonectin limits prostate cancer cell growth and survival

2012 ◽  
Vol 31 (5) ◽  
pp. 299-307 ◽  
Author(s):  
Kristina Kapinas ◽  
Katie M. Lowther ◽  
Catherine B. Kessler ◽  
Karissa Tilbury ◽  
Jay R. Lieberman ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Bone Matrix ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Cell Growth And Survival

scholarly journals Follistatin-like protein 1 sustains colon cancer cell growth and survival

Oncotarget ◽  
2018 ◽  
Vol 9 (58) ◽  
pp. 31278-31290 ◽  
Author(s):  
Gerolamo Bevivino ◽  
Silvia Sedda ◽  
Eleonora Franzè ◽  
Carmine Stolfi ◽  
Antonio Di Grazia ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Colon Cancer Cell ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Cell Growth And Survival

scholarly journals Estrogen-induced hypomethylation and overexpression of YAP1 facilitate breast cancer cell growth and survival

Neoplasia ◽  
2021 ◽  
Vol 23 (1) ◽  
pp. 68-79
Author(s):  
Jibran Sualeh Muhammad ◽  
Maha Guimei ◽  
Manju Nidagodu Jayakumar ◽  
Jasmin Shafarin ◽  
Aisha Saleh Janeeh ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Breast Cancer Cell ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Breast Cancer Cell Growth ◽  
Cell Growth And Survival

scholarly journals Lipophilic statins limit cancer cell growth and survival, via involvement of Akt signaling

PLoS ONE ◽  
2018 ◽  
Vol 13 (5) ◽  
pp. e0197422 ◽  
Author(s):  
Colin H. Beckwitt ◽  
Keisuke Shiraha ◽  
Alan Wells
Keyword(s):  
Cell Growth ◽  
Cancer Cell ◽  
Akt Signaling ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Cell Growth And Survival

scholarly journals SLC1A5 Mediates Glutamine Transport Required for Lung Cancer Cell Growth and Survival

2012 ◽  
Vol 19 (3) ◽  
pp. 560-570 ◽  
Author(s):  
Mohamed Hassanein ◽  
Megan D. Hoeksema ◽  
Masakazu Shiota ◽  
Jun Qian ◽  
Bradford K. Harris ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Lung Cancer Cell ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Glutamine Transport ◽  
Cell Growth And Survival

scholarly journals Starve Cancer Cells of Glutamine: Break the Spell or Make a Hungry Monster?

Cancers ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 804 ◽  
Author(s):  
Jie Jiang ◽  
Sankalp Srivastava ◽  
Ji Zhang
Keyword(s):  
Amino Acid ◽  
Cell Growth ◽  
Cancer Cells ◽  
Cancer Cell ◽  
Therapeutic Strategy ◽  
Glutamine Metabolism ◽  
Cancer Cell Growth ◽  
Growth And Survival ◽  
Tumor Environment ◽  
Cell Growth And Survival

Distinct from normal differentiated tissues, cancer cells reprogram nutrient uptake and utilization to accommodate their elevated demands for biosynthesis and energy production. A hallmark of these types of reprogramming is the increased utilization of, and dependency on glutamine, a nonessential amino acid, for cancer cell growth and survival. It is well-accepted that glutamine is a versatile biosynthetic substrate in cancer cells beyond its role as a proteinogenic amino acid. In addition, accumulating evidence suggests that glutamine metabolism is regulated by many factors, including tumor origin, oncogene/tumor suppressor status, epigenetic alternations and tumor microenvironment. However, despite the emerging understanding of why cancer cells depend on glutamine for growth and survival, the contribution of glutamine metabolism to tumor progression under physiological conditions is still under investigation, partially because the level of glutamine in the tumor environment is often found low. Since targeting glutamine acquisition and utilization has been proposed to be a new therapeutic strategy in cancer, it is central to understand how tumor cells respond and adapt to glutamine starvation for optimized therapeutic intervention. In this review, we first summarize the diverse usage of glutamine to support cancer cell growth and survival, and then focus our discussion on the influence of other nutrients on cancer cell adaptation to glutamine starvation as well as its implication in cancer therapy.

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