scholarly journals The Role of Skeletal Muscle Glycogen Breakdown for Regulation of Insulin Sensitivity by Exercise

2011 ◽  
Vol 2 ◽  
Author(s):  
Jørgen Jensen ◽  
Per Inge Rustad ◽  
Anders Jensen Kolnes ◽  
Yu-Chiang Lai
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Muscle Glycogen ◽  
Skeletal Muscle Glycogen ◽  
Glycogen Breakdown

scholarly journals Human skeletal muscle glycogen utilization in exhaustive exercise: role of subcellular localization and fibre type

2011 ◽  
Vol 589 (11) ◽  
pp. 2871-2885 ◽  
Author(s):  
Joachim Nielsen ◽  
Hans-Christer Holmberg ◽  
Henrik D. Schrøder ◽  
Bengt Saltin ◽  
Niels Ørtenblad
Keyword(s):  
Skeletal Muscle ◽  
Subcellular Localization ◽  
Muscle Glycogen ◽  
Fibre Type ◽  
Human Skeletal Muscle ◽  
Exhaustive Exercise ◽  
Skeletal Muscle Glycogen ◽  
Glycogen Utilization

Physiological role of skeletal muscle glycogen in starved mice

1987 ◽  
Vol 218 (3) ◽  
pp. 267-274 ◽  
Author(s):  
Minoru Sakaida ◽  
Jun Watanabe ◽  
Shinsuke Kanamura ◽  
Hirohiko Tokunaga ◽  
Ryokei Ogawa
Keyword(s):  
Skeletal Muscle ◽  
Muscle Glycogen ◽  
Physiological Role ◽  
Skeletal Muscle Glycogen

Time course of insulin sensitivity and skeletal muscle glycogen synthase activity after a single bout of exercise in horses

2007 ◽  
Vol 103 (3) ◽  
pp. 1063-1069 ◽  
Author(s):  
Shannon E. Pratt ◽  
Raymond J. Geor ◽  
Lawrence L. Spriet ◽  
L. Jill McCutcheon
Keyword(s):  
Skeletal Muscle ◽  
Insulin Sensitivity ◽  
Muscle Glycogen ◽  
Time Course ◽  
Glycogen Content ◽  
Activity Ratio ◽  
Glycogen Synthase ◽  
Muscle Glycogen Content ◽  
Skeletal Muscle Glycogen ◽  
Single Bout

The time course of insulin sensitivity, skeletal muscle glycogen and GLUT4 content, and glycogen synthase (GS) activity after a single bout of intense exercise was examined in eight horses. On separate days, a euglycemic-hyperinsulinemic clamp (EHC) was undertaken at 0.5, 4, or 24 h after exercise or after 48 h of rest [control (Con)]. There was no increase in mean glucose infusion rate (GIR) with exercise (0.5-, 4-, and 24-h trials), and GIR was significantly decreased at 0.5 h postexercise (GIR: 8.6 ± 2.7, 6.7 ± 2.0, 9.0 ± 2.0, and 10.6 ± 2.2 mg·kg−1·min−1 for Con and at 0.5, 4, and 24 h, respectively). Before each EHC, muscle glycogen content (mmol glucosyl units/kg dry muscle) was higher ( P < 0.05) for Con (565 ± 102) than for other treatments (317 ± 84, 362 ± 79, and 382 ± 74 for 0.5, 4, and 24 h, respectively) and muscle GLUT4 content was unchanged. Pre-EHC active-to-total GS activity ratio was higher ( P < 0.05) at 0.5, 4, and 24 h after exercise than in Con. Post-EHC active GS and GS activity ratio were higher ( P < 0.05) in Con and at 24 h. There was a significant inverse correlation ( r = −0.43, P = 0.02) between glycogen content and GS activity ratio but no relationship between GS activity and GIR. The lack of increase in insulin sensitivity, determined by EHC, after exercise that resulted in a significant reduction in muscle glycogen content is consistent with the slow rate of muscle glycogen resynthesis observed in equine studies.

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