scholarly journals Radioactive Beams in Particle Therapy: Past, Present, and Future

2020 ◽  
Vol 8 ◽  
Author(s):  
Marco Durante ◽  
Katia Parodi
Keyword(s):  
Particle Therapy ◽  
Radioactive Beams

scholarly journals Radioactive Beams for Image-Guided Particle Therapy: The BARB Experiment at GSI

2021 ◽  
Vol 11 ◽  
Author(s):  
Daria Boscolo ◽  
Daria Kostyleva ◽  
Mohammad Javad Safari ◽  
Vasiliki Anagnostatou ◽  
Juha Äystö ◽  
...  
Keyword(s):  
Heavy Ion ◽  
Ion Beams ◽  
Particle Therapy ◽  
Radioactive Ion Beams ◽  
Radioactive Beams ◽  
Fragment Separator ◽  
Phase 0 ◽  
Heavy Ion Therapy ◽  
Ion Therapy ◽  
Sufficient Intensity

Several techniques are under development for image-guidance in particle therapy. Positron (β+) emission tomography (PET) is in use since many years, because accelerated ions generate positron-emitting isotopes by nuclear fragmentation in the human body. In heavy ion therapy, a major part of the PET signals is produced by β+-emitters generated via projectile fragmentation. A much higher intensity for the PET signal can be obtained using β+-radioactive beams directly for treatment. This idea has always been hampered by the low intensity of the secondary beams, produced by fragmentation of the primary, stable beams. With the intensity upgrade of the SIS-18 synchrotron and the isotopic separation with the fragment separator FRS in the FAIR-phase-0 in Darmstadt, it is now possible to reach radioactive ion beams with sufficient intensity to treat a tumor in small animals. This was the motivation of the BARB (Biomedical Applications of Radioactive ion Beams) experiment that is ongoing at GSI in Darmstadt. This paper will present the plans and instruments developed by the BARB collaboration for testing the use of radioactive beams in cancer therapy.

AN ECR ION SOURCE FOR RADIOACTIVE BEAMS AT TRIUMF

1989 ◽  
Vol 50 (C1) ◽  
pp. C1-807-C1-811 ◽  
Author(s):  
P. McNEELY ◽  
G. ROY ◽  
J. SOUKUP ◽  
J. M. D'AURIA ◽  
L. BUCHMANN ◽  
...  
Keyword(s):  
Ion Source ◽  
Ecr Ion Source ◽  
Radioactive Beams

scholarly journals FRED: a fast Monte Carlo code on GPU for quality control in Particle Therapy

2020 ◽  
Vol 1548 ◽  
pp. 012020
Author(s):  
M De Simoni ◽  
M Fischetti ◽  
E Gioscio ◽  
M Marafini ◽  
R Mirabelli ◽  
...  
Keyword(s):  
Quality Control ◽  
Monte Carlo ◽  
Particle Therapy ◽  
Monte Carlo Code

scholarly journals Dealing with contaminants in Coulomb excitation of radioactive beams

2020 ◽  
Vol 1643 ◽  
pp. 012146
Author(s):  
L Morrison ◽  
K Hadyńska-Klęk ◽  
Zs Podolyák ◽  
L P Gaffney ◽  
L Kaya ◽  
...  
Keyword(s):  
Coulomb Excitation ◽  
Radioactive Beams

scholarly journals Critical Appraisal of Experimental Radiation Modalities for Malignant Astrocytomas

1990 ◽  
Vol 17 (2) ◽  
pp. 199-208 ◽  
Author(s):  
N.J. Laperriere
Keyword(s):  
Critical Appraisal ◽  
Clinical Results ◽  
Particle Therapy ◽  
Postoperative Radiation ◽  
Postoperative Radiation Therapy ◽  
Initial Management ◽  
Altered Fractionation ◽  
Malignant Astrocytomas ◽  
Prospective Trials ◽  
Radiation Sensitizers

ABSTRACT:The management of patients with supratentorial malignant astrocytomas has remained a major problem. Patients continue to die from a lack of local control in 90% of cases despite an improvement of median survival seen with the use of postoperative radiation therapy. Because of this, there has been considerable interest in exploring novel ways of possibly improving results. This paper reviews the rationale and clinical results with the use of altered fractionation schemes, brachytherapy, radiation sensitizers, hyperthermia, particle therapy, and radiosurgery in the treatment of these patients. Currently, there is no demonstrated advantage with the use of these experimental modalities in the initial management of patients. There would appear to be some benefit for selected patients who are treated with brachytherapy at recurrence, but its efficacy as part of initial management remains to be determined in ongoing randomized prospective trials.

scholarly journals Antitumor Activity of Protons and Molecular Hydrogen: Underlying Mechanisms

Cancers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 893
Author(s):  
Luc Rochette ◽  
Marianne Zeller ◽  
Yves Cottin ◽  
Catherine Vergely
Keyword(s):  
Cancer Treatment ◽  
Molecular Hydrogen ◽  
Nuclear Dna ◽  
Sharp Decrease ◽  
Particle Therapy ◽  
Great Promise ◽  
Small Molecular Weight ◽  
Proton Beam Radiotherapy ◽  
Different Types ◽  
Underlying Mechanisms

Understanding the structure and dynamics of the various hydrogen forms has been a subject of numerous studies. Protons (H+) and molecular hydrogen (H2) in the cell are critical in a wide variety of processes. A new cancer treatment uses H2, a biologically inactive gas. Due to its small molecular weight, H2 can rapidly penetrate cell membranes and reach subcellular components to protect nuclear DNA and mitochondria. H2 reduces oxidative stress, exerts anti-inflammatory effects, and acts as a modulator of apoptosis. Exogenous H2, administered by inhalation, drinking H2-rich water, or injecting H2-rich saline solution, is a protective therapy that can be used in multiple diseases, including cancer. In particle therapy, cyclotrons and synchrotrons are the accelerators currently used to produce protons. Proton beam radiotherapy (PBT) offers great promise for the treatment of a wide variety of cancers due to the sharp decrease in the dose of radiation at a defined point. In these conditions, H2 and different types of H2 donors may represent a novel therapeutic strategy in cancer treatment.

Sign in / Sign up

Export Citation Format

Share Document