Efficient event-driven simulations shed new light on microtubule organization in the plant cortical array

Microtubule organization in the green kingdom: chaos or self-order?

Journal of Cell Science ◽

10.1242/jcs.115.7.1345 ◽

2002 ◽

Vol 115 (7) ◽

pp. 1345-1354 ◽

Cited By ~ 7

Author(s):

Geoffrey O. Wasteneys

Keyword(s):

Mutational Analysis ◽

Dynamic Properties ◽

Microtubule Assembly ◽

Microtubule Organization ◽

Microtubule Associated Proteins ◽

The Past ◽

Plant Microtubules ◽

Associated Proteins ◽

Cortical Array ◽

Related Proteins

Plant microtubule arrays differ fundamentally from their animal, fungal and protistan counterparts. These differences largely reflect the requirements of plant composite polymer cell walls and probably also relate to the acquisition of chloroplasts. Plant microtubules are usually dispersed and lack conspicuous organizing centres. The key to understanding this dispersed nature is the identification of proteins that interact with and regulate the spatial and dynamic properties of microtubules. Over the past decade, a number of these proteins have been uncovered, including numerous kinesin-related proteins and a 65 kDa class of structural microtubule-associated proteins that appear to be unique to plants. Mutational analysis has identified MOR1, a probable stabilizer of microtubules that is a homologue of the TOGp-XMAP215 class of high-molecular-weight microtubule-associated proteins, and a katanin p60 subunit homologue implicated in the severing of microtubules. The identification of these two proteins provides new insights into the mechanisms controlling microtubule assembly and dynamics, particularly in the dispersed cortical array found in highly polarized plant cells.

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Platelet Microtubules in Clot Structure Formation and Contractile Force Generation: Investigation of a Controversy

Thrombosis and Haemostasis ◽

10.1055/s-0038-1661596 ◽

1986 ◽

Vol 56 (01) ◽

pp. 023-027 ◽

Cited By ~ 9

Author(s):

C J Jen ◽

L V McIntire

Keyword(s):

Network Formation ◽

Contractile Force ◽

Second Phase ◽

Clot Retraction ◽

Forming Process ◽

Microtubule Organization ◽

Physiological Processes ◽

Fibrin Network ◽

Two Parameters

SummaryWhether platelet microtubules are involved in clot retraction/ contraction has been controversial. To address this question we have simultaneously measured two clotting parameters, clot structural rigidity and isometric contractile force, using a rheological technique. For recalcified PRP clots these two parameters began rising together at about 15 min after CaCl2 addition. In the concentration range affecting microtubule organization in platelets, colchicine, vinca alkaloids and taxol demonstrated insignificant effects on both clotting parameters of a recalcified PRP clot. For PRP clots induced by adding small amounts of exogenous thrombin, the kinetic curves of clot rigidity were biphasic and without a lag time. The first phase corresponded to a platelet-independent network forming process, while the second phase corresponded to a platelet-dependent process. These PRP clots began generating contractile force at the onset of the second phase. For both rigidity and force parameters, only the second phase of clotting kinetics was retarded by microtubule affecting reagents. When PRP samples were clotted by adding a mixture of CaCl2 and thrombin, the second phase clotting was accelerated and became superimposed on the first phase. The inhibitory effects of micro tubule affecting reagents became less pronounced. Thrombin clotting of a two-component system (washed platelets/ purified fibrinogen) was also biphasic, with the second phase being microtubule-dependent. In conclusion, platelet microtubules are important in PRP clotted with low concentrations of thrombin, during which fibrin network formation precedes platelet-fibrin interactions. On the other hand they are unimportant if a PRP clot is induced by recalcification, during which the fibrin network is constructed in the presence of platelet-fibrin interactions. The latter is likely to be more analogous to physiological processes in vivo.

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Discrete Value Control Using Event-Driven Neural Controller

IEEJ Transactions on Electronics Information and Systems ◽

10.1541/ieejeiss.129.2121 ◽

2009 ◽

Vol 129 (12) ◽

pp. 2121-2128 ◽

Cited By ~ 3

Author(s):

Hiroki Itakura ◽

Eiji Konaka

Keyword(s):

Neural Controller ◽

Event Driven

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Event-Driven Architecture Overview

10.1571/bda2-2-06cc ◽

2006 ◽

Cited By ~ 90

Author(s):

Brenda Michelson

Keyword(s):

Event Driven

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JAVASCRIPT ASYNCHRONOUS PROGRAMMING

HUE UNIVERSITY JOURNAL OF SCIENCE TECHNIQUES AND TECHNOLOGY ◽

10.26459/hueuni-jtt.v128i2b.5104 ◽

2019 ◽

Vol 128 (2B) ◽

pp. 5-16

Author(s):

Tran Thanh Luong ◽

Le My Canh

Keyword(s):

Design Patterns ◽

Source Code ◽

Object Oriented ◽

Exception Handling ◽

Code Smells ◽

Asynchronous Programming ◽

Event Driven ◽

Programming Patterns ◽

The Impact

JavaScript has become more and more popular in recent years because its wealthy features as being dynamic, interpreted and object-oriented with first-class functions. Furthermore, JavaScript is designed with event-driven and I/O non-blocking model that boosts the performance of overall application especially in the case of Node.js. To take advantage of these characteristics, many design patterns that implement asynchronous programming for JavaScript were proposed. However, choosing a right pattern and implementing a good asynchronous source code is a challenge and thus easily lead into less robust application and low quality source code. Extended from our previous works on exception handling code smells in JavaScript and exception handling code smells in JavaScript asynchronous programming with promise, this research aims at studying the impact of three JavaScript asynchronous programming patterns on quality of source code and application.

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