scholarly journals Shear Speed-Regulated Properties of Long-Acting Docetaxel Control Release Poly (Lactic-Co-Glycolic Acid) Microspheres

2020 ◽  
Vol 11 ◽  
Author(s):  
Yuhao Zheng ◽  
Fan Sheng ◽  
Zihang Wang ◽  
Guang Yang ◽  
Chenguang Li ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Control Release ◽  
Shear Speed ◽  
Long Acting

scholarly journals Long-acting reversible contraception by effervescent microneedle patch

2019 ◽  
Vol 5 (11) ◽  
pp. eaaw8145 ◽  
Author(s):  
Wei Li ◽  
Jie Tang ◽  
Richard N. Terry ◽  
Song Li ◽  
Aurelie Brunie ◽  
...  
Keyword(s):  
Biodegradable Polymer ◽  
Glycolic Acid ◽  
Interstitial Fluid ◽  
Threshold Level ◽  
Reproductive Age ◽  
Women Of Reproductive Age ◽  
Human Participants ◽  
Microneedle Patch ◽  
Long Acting

To increase access to long-acting contraception, we developed a reversible contraceptive microneedle patch that is simple-to-administer, slowly releases contraceptive hormone (levonorgestrel) for >1 month, and generates no biohazardous sharps waste. After manually pressing the patch to skin for 1 min, microneedles rapidly separate from the patch within the skin due to effervescence triggered by contact with skin’s interstitial fluid, as demonstrated in rats and human participants. Long-acting contraception is achieved by formulating microneedles with a biodegradable polymer [poly(lactic-co-glycolic) acid] that slowly releases levonorgestrel for ~1 month in vitro. In rats, the patch maintained levonorgestrel concentration above the human contraceptive threshold level for >1 month, and a placebo microneedle patch was well-tolerated in human participants. Women of reproductive age in three continents demonstrated interest in and preference for long-acting contraception by microneedle patch. These studies indicate that an effervescent microneedle patch could facilitate greater access to long-acting contraception.

Poly (lactic-co-glycolic acid) & tocopheryl polyethylene glycol succinate nanoparticles for the treatment of different brain cancer

2021 ◽  
Vol 21 ◽  
Author(s):  
Akhil Kumar ◽  
Sankha Bhattacharya ◽  
Charan Singh ◽  
Vikas Sharma
Keyword(s):  
Brain Tumour ◽  
Glycolic Acid ◽  
Polymeric Nanoparticles ◽  
Control Release ◽  
High Specificity ◽  
Plga Nanoparticles ◽  
Glycol Succinate ◽  
New Techniques ◽  
Pharmaceutical Application ◽  
Enhanced Permeability And Retention

Abstract: Nanotechnology and material science developments emerge in the manufacturing of various novel modes of drug delivery, which have proven scientifically promising. Polymer nanoparticles have high stability, high specificity, high drug-carrying power, control release and potential to be used in various pathways. They are able to supply hydrophilic and hydrophobic molecules with medicines. In this review, we have discussed about the different types of brain tumour, different PLGA (poly lactic-co-glycolic acid) nanostructure, PLGA in brain tumour targeting, and the recent advancement of PLGA based nanoparticles. This review focused on the method of preparation of polymeric nanoparticles, the significance of EPR (enhanced permeability and retention) effect with PLGA, the significance of TPGS in cancer, and discussed the pharmaceutical application of PLGA nanoparticles. We expect these polymeric nanoparticles will be very successful and efficient for disease targeting in the future and new techniques will become.

scholarly journals Exenatide-loaded inside-porous poly(lactic-co-glycolic acid) microspheres as a long-acting drug delivery system with improved release characteristics

Drug Delivery ◽  
2020 ◽  
Vol 27 (1) ◽  
pp. 1667-1675
Author(s):  
Junqiu Zhai ◽  
Zhanlun Ou ◽  
Liuting Zhong ◽  
Yu-e Wang ◽  
Li-Ping Cao ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Delivery System ◽  
Delivery System ◽  
Glycolic Acid ◽  
Long Acting ◽  
Porous Poly

Design of Single Dose Control Release Device for Antigen Delivery based on Poly (Lactic-Co- Glycolic Acid)

2010 ◽  
Vol 3 (3) ◽  
pp. 1075-1084
Author(s):  
U K Jain ◽  
Vivek Shrivastava
Keyword(s):  
Single Dose ◽  
Infectious Diseases ◽  
Glycolic Acid ◽  
Control Release ◽  
Specific Response ◽  
Antigen Delivery ◽  
Release Device ◽  
Plga Microparticles ◽  
Dose Control ◽  
Dose Vaccine

Vaccines are non pathogenic construct of pathogens, which exploit the ability of immune system to mount specific response against a particular pathogen, thereby protecting the host against that pathogen. The incidence of many infectious diseases have gone down considerably during last several decades  as a consequence of vaccination, but successful vaccination often requires multiple immunizations. Thus the development of new vaccines, particularly the conversion of multiple dose vaccine into single dose vaccine has become an area of research. In order to be fully immunized against most infectious diseases like hepatitis B, tetanus, diphtheria, the successful administration of three doses is needed. To increase immunization coverage, to reduce excessive vaccine wastage, and to reduce the cost of immunization, vaccine in the formats other than the standard multidose formats is very much required. In the present article, we review key issues in developing single dose control release device for antigen delivery with special emphasis on design and use of poly (lactic-co- glycolic acid) or (PLGA) microparticles for controlled delivery of  antigen , difficulties in encapsulating antigen inside PLGA microparticles and the various approaches which have been used successfully to encapsulate antigen inside microparticles.

scholarly journals Efficient aqueous remote loading of peptides in poly(lactic-co-glycolic acid)

2021 ◽  
Author(s):  
Morgan Giles ◽  
Justin Hong ◽  
Yayuan Liu ◽  
Jie Tang ◽  
Tinghui Li ◽  
...  
Keyword(s):  
Organic Solvent ◽  
Glycolic Acid ◽  
Short Exposure ◽  
Duration Of Action ◽  
Remote Loading ◽  
Long Acting ◽  
Charged Peptides ◽  
Positively Charged

Abstract Poly(lactic-co-glycolic acid) (PLGA) long-acting release (LAR) depots are effective for extending the duration of action of peptide drugs. New market approvals have been slow with dated organic-solvent-based microencapsulation approaches. We describe efficient organic-solvent-free remote encapsulation based on the capacity of common acid-capped PLGA to bind, and absorb into the polymer phase, net positively charged peptides in aqueous solution after short exposure at modest temperature. Leuprolide encapsulated by this approach in low-molecular-weight PLGA 75/25 microspheres slowly and continuously released peptide for over 56 days in vitro and suppressed testosterone production in rats in an equivalent manner as the 1-month Lupron Depot®. The technique is generalizable to encapsulate a number of net cationic peptides of various size, including octreotide, with competitive loading and encapsulation efficiencies to traditional techniques. In certain cases, in vitro and in vivo performance of remote-loaded PLGA microspheres exceeded that relative to marketed products and displayed important features not currently possible with existing encapsulation strategies.

Highly porous large poly(lactic-co-glycolic acid) microspheres adsorbed with palmityl-acylated exendin-4 as a long-acting inhalation system for treating diabetes

Biomaterials ◽  
2011 ◽  
Vol 32 (6) ◽  
pp. 1685-1693 ◽  
Author(s):  
Hyunuk Kim ◽  
Hongil Park ◽  
Juho Lee ◽  
Tae Hyung Kim ◽  
Eun Seong Lee ◽  
...  
Keyword(s):  
Glycolic Acid ◽  
Long Acting ◽  
Highly Porous
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