scholarly journals Anti-Bronchospasmodic Effect of JME-173, a Novel Mexiletine Analog Endowed With Highly Attenuated Anesthetic Activity

2020 ◽  
Vol 11 ◽  
Author(s):  
Katharinne Ingrid Moraes Carvalho ◽  
Diego de Sá Coutinho ◽  
Humberto Cavalcante Joca ◽  
Artur Santos Miranda ◽  
Jader dos Santos Cruz ◽  
...  
Keyword(s):  
Anesthetic Activity

ChemInform Abstract: SYNTHESIS AND LOCAL ANESTHETIC ACTIVITY OF 6-(Ω-AMINO-Ω-ARYLALKYL)BENZO-1,4-DIOXANES

1985 ◽  
Vol 16 (17) ◽  
Author(s):  
V. K. DAUKSHAS ◽  
YU. YU. RAMANAUSKAS ◽  
E. B. UDRENAITE ◽  
A. B. BRUKSHTUS ◽  
V. V. LAPINSKAS ◽  
...  
Keyword(s):  
Local Anesthetic ◽  
Anesthetic Activity ◽  
Local Anesthetic Activity

On the Hydrogen Bond Breaking Ability of Fluorocarbons Containing Higher Halogens

1974 ◽  
Vol 52 (21) ◽  
pp. 3612-3622 ◽  
Author(s):  
Thérèse Di Paolo ◽  
C. Sandorfy
Keyword(s):  
Hydrogen Bond ◽  
Hydrogen Bonds ◽  
Bond Breaking ◽  
Anesthetic Activity ◽  
Competitive Mechanism ◽  
Infrared Measurements ◽  
Donor Acceptor

Infrared measurements show that fluorocarbons containing higher halogens are able to open O—H---O, N—H---N, S—H---S, N—H---O=C, type hydrogen bonds. This is probably due to a competitive mechanism of association consisting in the formation of donor–acceptor complexes. It is suggested that the breaking or perturbation of hydrogen bonds by this mechanism is of importance for the explanation of the anesthetic activity of these compounds.

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