scholarly journals Targeting B7-H3 Immune Checkpoint With Chimeric Antigen Receptor-Engineered Natural Killer Cells Exhibits Potent Cytotoxicity Against Non-Small Cell Lung Cancer

2020 ◽  
Vol 11 ◽  
Author(s):  
Shuo Yang ◽  
Bihui Cao ◽  
Guangyu Zhou ◽  
Lipeng Zhu ◽  
Lu Wang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Chimeric Antigen Receptor ◽  
Immune Checkpoint ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells

scholarly journals Circulating NKp46+ Natural Killer cells have a potential regulatory property and predict distinct survival in Non-Small Cell Lung Cancer

2018 ◽  
Vol 8 (2) ◽  
pp. e1527498 ◽  
Author(s):  
Emilie Picard ◽  
Yann Godet ◽  
Caroline Laheurte ◽  
Magalie Dosset ◽  
Jeanne Galaine ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells ◽  
Regulatory Property

scholarly journals Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 764-768 ◽  
Author(s):  
PA Jr Bunn ◽  
I Linnoila ◽  
JD Minna ◽  
D Carney ◽  
AF Gazdar
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Endocrine Cells ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells ◽  
Leu 7

Abstract Small cell lung cancer is distinguished from other lung cancer histologic types by possessing a variety of neuroendocrine properties. Anti-Leu-7 is a monoclonal antibody that recognizes a 110,000-dalton molecular weight glycoprotein initially described on natural killer cells and subsequently reported on a variety of normal and malignant neural and neuroendocrine cell types. We have found intense anti-Leu-7 binding to a large number of small cell lung cancers, while other lung cancer types were negative or showed only weak and focal binding. Other antigens expressed by natural killer cells, lymphocytes, and monocytes were never or less often expressed on small cell lung cancer cells. In addition, we report for the first time anti-Leu-7 binding by carcinoids, carotid body tumors, pheochromocytomas, endocrine cells of the fetal bronchus and the adult intestine, and select pancreatic islet cells. Anti-Leu-7 binding by small cell lung cancer is consistent with a derivation from pulmonary precursor cells, and anti-Leu-7 staining is clinically useful for the identification of human neuroendocrine tumors of the amine precursor uptake and decarboxylation (“APUD”) type.

scholarly journals The Proangiogenic Phenotype of Natural Killer Cells in Patients with Non-Small Cell Lung Cancer

Neoplasia ◽  
2013 ◽  
Vol 15 (2) ◽  
pp. 133-IN7 ◽  
Author(s):  
Antonino Bruno ◽  
Chiara Focaccetti ◽  
Arianna Pagani ◽  
Andrea S. Imperatori ◽  
Marco Spagnoletti ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells

scholarly journals The level of circulating NKp46+ CD56dim CD16+ natural killer cells predicts distinct survival in non-small cell lung cancer

2018 ◽  
Vol 29 ◽  
pp. viii485
Author(s):  
E. Picard ◽  
Y. Godet ◽  
C. Laheurte ◽  
L. Boullerot ◽  
E. Lauret Marie Joseph ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells

scholarly journals MA13.04 Harnessing Natural Killer Cells to Treat Metastatic Small Cell Lung Cancer

2021 ◽  
Vol 16 (3) ◽  
pp. S182
Author(s):  
S. Best ◽  
J. Hess ◽  
F. Souza-Fonseca Guimaraes ◽  
A. Kersbergen ◽  
S. Hyslop ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells

PD-1+ natural killer cells in human non-small cell lung cancer can be activated by PD-1/PD-L1 blockade

2020 ◽  
Vol 69 (8) ◽  
pp. 1505-1517 ◽  
Author(s):  
Marcel P. Trefny ◽  
Monika Kaiser ◽  
Michal A. Stanczak ◽  
Petra Herzig ◽  
Spasenija Savic ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells

scholarly journals Small cell lung cancer, endocrine cells of the fetal bronchus, and other neuroendocrine cells express the Leu-7 antigenic determinant present on natural killer cells

Blood ◽  
1985 ◽  
Vol 65 (3) ◽  
pp. 764-768
Author(s):  
PA Jr Bunn ◽  
I Linnoila ◽  
JD Minna ◽  
D Carney ◽  
AF Gazdar
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Endocrine Cells ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells ◽  
Leu 7

Small cell lung cancer is distinguished from other lung cancer histologic types by possessing a variety of neuroendocrine properties. Anti-Leu-7 is a monoclonal antibody that recognizes a 110,000-dalton molecular weight glycoprotein initially described on natural killer cells and subsequently reported on a variety of normal and malignant neural and neuroendocrine cell types. We have found intense anti-Leu-7 binding to a large number of small cell lung cancers, while other lung cancer types were negative or showed only weak and focal binding. Other antigens expressed by natural killer cells, lymphocytes, and monocytes were never or less often expressed on small cell lung cancer cells. In addition, we report for the first time anti-Leu-7 binding by carcinoids, carotid body tumors, pheochromocytomas, endocrine cells of the fetal bronchus and the adult intestine, and select pancreatic islet cells. Anti-Leu-7 binding by small cell lung cancer is consistent with a derivation from pulmonary precursor cells, and anti-Leu-7 staining is clinically useful for the identification of human neuroendocrine tumors of the amine precursor uptake and decarboxylation (“APUD”) type.

Natural Killer Cells as a Potential Biomarker for Predicting Immunotherapy Efficacy in Patients with Non-Small Cell Lung Cancer

2020 ◽  
Vol 15 (2) ◽  
pp. 241-247 ◽  
Author(s):  
Yong-Hee Cho ◽  
Myeong Geun Choi ◽  
Dong Ha Kim ◽  
Yun Jung Choi ◽  
Seon Ye Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Natural Killer Cells ◽  
Small Cell Lung Cancer ◽  
Natural Killer ◽  
Cell Lung Cancer ◽  
Small Cell ◽  
Small Cell Lung ◽  
Killer Cells ◽  
Potential Biomarker
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